3TKU,3QFV


Conserved Protein Domain Family
STKc_MRCK_beta
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cd05624: STKc_MRCK_beta 
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Catalytic domain of the Protein Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) beta
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MRCK-beta is expressed ubiquitously in many tissues. MRCK is activated via interaction with the small GTPase Cdc42. MRCK/Cdc42 signaling mediates myosin-dependent cell motility. The MRCK-beta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. This alignment model includes the dimerization domain.
Links
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Statistics
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PSSM-Id: 270774
Aligned: 5 rows
Threshold Bit Score: 939.048
Created: 5-Sep-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Structure:3TKU: Human MRCK-beta binds Fasudil; contacts at 4A.
  • Structure:3QFV: Human MRCK-beta binds inhibitor TPCA-1; contacts at 4A.
  • Comment:also based on the binding of other AGC kinases to ATP analogs
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
3TKU_A         19 AKVRLKKLEQLLLDGPWRNesALSVETLLDVLVCLYTECsh-saLRRDKYVAEFleWAKPFTQLVKEMQLHREDFEIIKV 97   human
3QFV_A          3 AKVRLKKLEQLLLDGPWRNesALSVETLLDVLVCLYTECsh-saLRRDKYVAEFleWAKPFTQLVKEMQLHREDFEIIKV 81   human
XP_421380       3 AKVRLKRLEQLVLDGPQRNdsVLSVETLLDLLVGVYAECsrdspLRRDRYVSDFleWARPFTKLVKEMQLHRDDFEIIKV 82   chicken
AAH41741        3 AKVRLKRLEQLLLDGPQRNeaAVSVETLLDVLLCLYTECts-stLRRDKYVSEFleWAKPFTDLLKGMQLHRDDFEIIKV 81   African clawe...
NP_001038590    3 AKVRLKKLEQLLLDGHQKNdkSLSVETLLDILICLYNECsn-spLKREKHVTDFleWVKPFTTTVKEMRLHRDDFEMLKV 81   zebrafish

Feature 1         #####   #            # #                               #                ###   # 
3TKU_A         98 IGRGAFGEVAVVKMKnTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDL 177  human
3QFV_A         82 IGRGAFGEVAVVKMKnTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDL 161  human
XP_421380      83 IGRGAFGEVAVVKMKcTERIYAMKILNKWEMLKRAETACFREERNVLVNGDCQWITTLHYAFQDENYLYLVMDYYVGGDL 162  chicken
AAH41741       82 IGRGAFGEVAVVRLKsTERIYAMKILNKWEMLKRAETACFREERNVLVNGDCQWITTLHYAFQDENYLYLVMDYYVGGDL 161  African clawe...
NP_001038590   82 IGRGAFGEVAVVKMKhTERVYAMKILNKWEMLKRAETACFREERNVLVNGDCQWITTLHYAFQDDNYLYLVMDYYVGGDL 161  zebrafish

Feature 1                                               # # ## #         ##                       
3TKU_A        178 LTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPD 257  human
3QFV_A        162 LTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPD 241  human
XP_421380     163 LTLLSKFEDKLPEDMARFYIGEMVLAIHSIHELHYVHRDIKPDNVLLDMNGHIRLADFGSCLKMSEDGTVQSSVAVGTPD 242  chicken
AAH41741      162 LTLLSKFEDRLPEDMSRFYLAEMVLAIHSIHQLHYVHRDIKPDNILLDMNGHIRLADFGSCLKMNKDGTVQSSVAVGTPD 241  African clawe...
NP_001038590  162 LTLLSKFEDRLPEDMAKFYVAEMVLAIHSIHQQRYVHRDIKPDNVLLDMNGHIRLADFGSCLKMMQDGTVQSSVAVGTPD 241  zebrafish

Feature 1                                                                                         
3TKU_A        258 YISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEEAKDLIQRLI 337  human
3QFV_A        242 YISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEEAKDLIQRLI 321  human
XP_421380     243 YISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEEAKDLIQRLI 322  chicken
AAH41741      242 YISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHIGDVSESAKDLIQRLI 321  African clawe...
NP_001038590  242 YISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHITDVSEDAKDLIQRLI 321  zebrafish

Feature 1                                                                                         
3TKU_A        338 CSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYIPDVSSPSDTSNFDVDDDVLRNTEILPPGSHTGFSGLHLPFIGF 417  human
3QFV_A        322 CSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYIPDVSSPSDTSNFDVDDDVLRNTEILPPGSHTGFSGLHLPFIGF 401  human
XP_421380     323 CSRERRLGQNGIEDFKSHAFFEGLNWDNIRNLEAPYIPDVSSPSDTSNFDVDDDVLRNPEVVPPSSHTGFSGLHLPFVGF 402  chicken
AAH41741      322 CSRERRLGQNGIDDFKAHPFFEGIDWDNIRNLEAPYIPDVSSPSDTSNFDVDDDILRNPEVIPSSTHSGFSGFHLPFVGF 401  African clawe...
NP_001038590  322 CSRERRLGQHGIEEFRKHAFFSGIDWENIRNMEAPYIPDVSSPSDTSNFDVDDDVLKNPDIAPPVSHTGFTGQHLPFVGF 401  zebrafish

Feature 1                   
3TKU_A        418 TFTTESCFSD 427  human
3QFV_A        402 TFTTESCFSD 411  human
XP_421380     403 TYTTDSSLSD 412  chicken
AAH41741      402 TYTTDSCFSD 411  African clawed frog
NP_001038590  402 TYTTESCFSD 411  zebrafish

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