4AW2


Conserved Protein Domain Family
STKc_MRCK_alpha
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cd05623: STKc_MRCK_alpha 
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Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MRCK-alpha is expressed ubiquitously in many tissues. It plays a role in the regulation of peripheral actin reorganization and neurite outgrowth. It may also play a role in the transferrin iron uptake pathway. MRCK is activated via interaction with the small GTPase Cdc42. MRCK/Cdc42 signaling mediates myosin-dependent cell motility. The MRCK-alpha subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. This alignment model includes the dimerization domain.
Links
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Statistics
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PSSM-Id: 270773
Aligned: 4 rows
Threshold Bit Score: 898.994
Created: 5-Sep-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 31 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:The active site is composed of the ATP binding site and the substrate binding site. The substrate binding site is based on the binding of peptide substrates to the AGC kinases, PKA and PKB.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        #
4AW2_A          3 EVRLRQLEQFILDGPAqtngqcFSVETLLDILICLYDECnnsPLRREKNILEYLEWAKPFTSKVKQMRLHREDFEILKVI 82   Norway rat
CAH68979        4 EVRLKKLEKLIMDGPSqssgqcFSMETLLDILVCLYDECsssPIRREKNVLEFLDWAKPFTSKVKQMRLHKEDFEILKVI 83   zebrafish
XP_001231317    4 EVRLKQLEQFILDGPTqtngqcFSVETLLDILICLYDECnnsPLRREKNILEYLEWAKPFTSKVKQMRLHKEDFEILKVI 83   chicken
XP_002938889    4 EVRLRQLEQLVLNGPGrg--gsLSVESLLDSLLCLYDECsasPLRRDKHINDYIQWAKPFALKVKQMRLHKEDFEILKVI 81   western clawe...

Feature 1         ####   #            # #                               #               ## #   # #
4AW2_A         83 GRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLL 162  Norway rat
CAH68979       84 GRGAFGEVAVVKVKNTDKVFAMKILNKWEMLKRAETACFREERDVLVNGDCQWITTLHYAFQDENNLYLVMDYYVGGDLL 163  zebrafish
XP_001231317   84 GRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDNQWITTLHYAFQDENYLYLVMDYYVGGDLL 163  chicken
XP_002938889   82 GRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDSQWITTLHYAFQDDNNLYLVMDYYVGGDLL 161  western clawe...

Feature 1                                              # # ## #         ##  #              ###### 
4AW2_A        163 TLLSKFEDRLPEEMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDY 242  Norway rat
CAH68979      164 TLLSKFEDRLPEDMAKFYLAEMVLAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDY 243  zebrafish
XP_001231317  164 TLLSKFEDRLPEDMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDY 243  chicken
XP_002938889  162 TLLSKFEDRLPEDMSRFYLAEMVLAIDSVHQLHYVHRDIKPDNILLDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDY 241  western clawe...

Feature 1                                       #     #  #                                        
4AW2_A        243 ISPEILQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPTQVTDVSENAKDLIRRLIC 322  Norway rat
CAH68979      244 ISPEILQAMEDGKGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPLQVTDVSEDAKDLVRRLIC 323  zebrafish
XP_001231317  244 ISPEILQAMEDGKGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSESAKDLIRRLIC 323  chicken
XP_002938889  242 ISPEILQAMEDGKGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPTQLADVSENAKDLIRRLIC 321  western clawe...

Feature 1                                                                                         
4AW2_A        323 SREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFT 402  Norway rat
CAH68979      324 SREHRLGQNGIEDFKQHPFFTGIDWDNIRTCEAPYIPEVSSPTDTSNFDVDDDCLKNCETLPPPSHTAFSGHHLPFVGFT 403  zebrafish
XP_001231317  324 SREHRLGQNGIEDFKNHPFFAGIDWDNIRNCDAPYIPEVSSPTDTSNFDVDDDCLKNSETMPPPSHTAFSGHHLPFVGFT 403  chicken
XP_002938889  322 SREHRLGQNGIEDFKNHPFFVGIDWDNIRNCEAPYIPEVSSPTDTSNFDVDDDCLKNCETMPPPTHTGFSGHHLPFVGFT 401  western clawe...

Feature 1                  
4AW2_A        403 YTSSCVLSD 411  Norway rat
CAH68979      404 YTSKCTLSD 412  zebrafish
XP_001231317  404 YTSSCVLSD 412  chicken
XP_002938889  402 YTSNCVLSD 410  western clawed frog

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