Conserved Protein Domain Family
STKc_nPKC_delta

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cd05620: STKc_nPKC_delta 
Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-delta plays a role in cell cycle regulation and programmed cell death in many cell types. It slows down cell proliferation, inducing cell cycle arrest and enhancing cell differentiation. PKC-delta is also involved in the regulation of transcription as well as immune and inflammatory responses. It plays a central role in the genotoxic stress response that leads to DNA damaged-induced apoptosis. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. The nPKC-delta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 173710
View PSSM: cd05620
Aligned: 4 rows
Threshold Bit Score: 694.766
Threshold Setting Gi: 57524924
Created: 31-Aug-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
  next features
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the binding of peptide substrates and ATP analogs to the AGC kinases, PKA and PKB.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          #####   #            # #                                #               ## #  
NP_001006133 361 KVLGKGSFGKVLLAELKGknEFFAIKALKKDVVLIDDDVECTMVEKRVLALAWENPFLTHLYCTFQTKDHLFFVMEFLNG 440 chicken
NP_999873    361 KVLGKGSFGKVLLAELKGtgEWFAVKALKKDVVLMDDDVECTMVEKRVLALAWDNPFLTHLYSTFQTKEHLFFVMEYLNG 440 zebrafish
AAH78019     360 KVLGKGSFGKVLLAELKGkgEYFAVKALKKDVVLIDDDVECTMVEKRVLALAWENPFLTHVHCTFQTKEHLFFVMEFLNG 439 African clawed ...
Q05655       353 KVLGKGSFGKVLLGELKGrgEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNG 432 human
Feature 1         # #                                                   # # ## #         ##  #   
NP_001006133 441 GDLMFHIQDKGRFDLYRATFYGAEILCGLQFLHSkgiiyrkftsitsepNWSSFRDLKLDNVMLDKEGRIKIADFGMCKE 520 chicken
NP_999873    441 GDLMFHIQEKGRFDLYRATFYAAEIVCGLQFLHS---------------KGIIYRDLKLDNVMLDGDGHIKIADFGMCKE 505 zebrafish
AAH78019     440 GDLMFHIQDKGRFDLYRATFYASEIICGLQFLHS---------------KGIIYRDLKLDNVMLDRDGHIKIADFGMCKE 504 African clawed ...
Q05655       433 GDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHS---------------KGIIYRDLKLDNVLLDRDGHIKIADFGMCKE 497 human
Feature 1                  ######                          #     #  #                            
NP_001006133 521 NVVGENKASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWItKESKD 600 chicken
NP_999873    506 NVFGDNRATTFCGTPDYIAPEILLGQQYSFSVDWWSFGVLVYEMLIGQSPFHGDDEDELFESIRMDTPHYPRWIlLDTRD 585 zebrafish
AAH78019     505 NVYGDNKASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRQDTPHYPRWItKESKD 584 African clawed ...
Q05655       498 NIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWItKESKD 577 human
Feature 1                                                                                        
NP_001006133 601 LLEKLFERDPTRRLGvtGNIRDHPFFKTINWTTLEKREIDPPFKPKVKsasDYNNFDREFLNEKPKLSYSDKNLIDSMDQ 680 chicken
NP_999873    586 MLERLFERDPSRRLGivGNIRGHSFFKTVNWAALEGREVDPPFKPKVKapnDCSNFDREFLSEKPRLSHCEKGLIDSMDQ 665 zebrafish
AAH78019     585 ILEKFFERDPFKRLGvvGNIKLHPFFKTINWTALERRELDPPFKPKVKspsDYSNFDREFLSEKPRLSFSDKNLIDSMDQ 664 African clawed ...
Q05655       578 ILEKLFEREPTKRLGvtGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKsprDYSNFDQEFLNEKARLSYSDKNLIDSMDQ 657 human
Feature 1                   
NP_001006133 681 SAFAGFSFTNP 691 chicken
NP_999873    666 CAFAGFSFINP 676 zebrafish
AAH78019     665 SAFHGFSFINP 675 African clawed frog
Q05655       658 SAFAGFSFVNP 668 human

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