Conserved Protein Domain Family
STKc_LATS

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cd05598: STKc_LATS 
Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LATS was originally identified in Drosophila using a screen for genes whose inactivation led to overproliferation of cells. In tetrapods, there are two LATS isoforms, LATS1 and LATS2. Inactivation of LATS1 in mice results in the development of various tumors, including sarcomas and ovarian cancer. LATS functions as a tumor suppressor and is implicated in cell cycle regulation. The LATS subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 270749
View PSSM: cd05598
Aligned: 17 rows
Threshold Bit Score: 597.762
Threshold Setting Gi: 326427676
Created: 24-Aug-2006
Updated: 2-Mar-2014
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the binding of peptide substrates and ATP analogs to the AGC kinases, PKA and PKB.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                 #####   #            # #                               #               #
gi 52783106   703 SMFVKIKTLGIGAFGEVCLARKvdtkALYATKTLRKKDVLlrNQVAHVKAERDILAEAdNEWVVRLYYSFQDkdNLYFVM 782
gi 17509105   500 SHFTVISHIGVGAFGKVSLVRKndtrKVYAMKSLEKADVImkQQAAHVKAERDILAEAdSPWIVRLFFSFQDdaCLYFIM 579
gi 427779909  316 SMFKHIKRIGVGAFGEVALVRKhdtnQLYAMKTLSKEDVLkrNQVAHVKAERDILAEAdNEWVVKLYYSFQDerNLYFVM 395
gi 260784234   36 SMFVKIKTLGVGAFGEVALARKvdtqTLHAMKTLRKSDVLkrNQVAHVKAERDILSEAdNEWVVRLYYSFQDdeNLYFVM 115
gi 443698435  148 SMFEQIKVIGVGAFGEVSLVHKtgfqKLYAMKTLRKNDVLrrNQVAHVKAERDILAEAdNEWVVKLYYSFQDeeHLYFVM 227
gi 405976942  694 DMFEKIQTLGVGAFGEVSLVRKrdvgHLYAMKTLRKSDVLkrNQVAHVKAERDILAEAdNEWVVKLYYSFQDrdNLYFVM 773
gi 340375485  392 DQFDIVKPIGVGAFGVVSLVRKkdtrRLYAMKSLRKADVVrrNQVAHVKAERDILAEAdNEWVVKLYYSFQDaeCLYFVM 471
gi 339248899  481 SMFEKIKIIGVGAFGEVTLKDTn---TLFAMKVLRKLDVIkrNQAAHVKAERDILSKAdNEWVVKLYYSFQDkdSLFFIM 557
gi 459176910   23 SMYDMIKSIGVGAFGKVMLARNktsdKLNAIKFLKKKDVLrrNQVAHVKAERDILSEAdNDWVVKLYYTFQDkeNLYFVM 102
gi 360044130    2 LGSERLFYKSVGAFGKVWLVRKkdnnQLYAMKLLNKRDVVerRQLAHVQAERDILAEAdNEWVVKLFFSFQDsrALYLVM 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         # #   # #                                    # # ## #         ##  #             
gi 52783106   783 DYIpGGDMMSLLIRmgIFPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDrdGHIKLTDFGLCTGFRWTHDSKYY 862
gi 17509105   580 EYVpGGDMMTLLIQkgIFEEDLARFYIAELACAIEYVHNVGFIHRDLKPDNILIDqhGHIKLTDFGLCTGLRWTHDRRYY 659
gi 427779909  396 DYIpGGDLMSLLIRlgVFEEHLARFYIAELVLALESVHKLGFIHRDIKPDNVLIDrdGHIKLTDFGLCTGFRWTHNSKYY 475
gi 260784234  116 DYIpGGDLMSLLIKkgIFEQGLAQFYTAELVCAIESVHKMGFIHRDIKPDNILIDrdGHIKLTDFGLCTGFRWTHDSKYY 195
gi 443698435  228 DYIpGGDMMSLLIKkgIFEEHLACFYIAELTVAIESVHKMGFIHRDIKPDNILIDsqGHIKLTDFGLCTGFRWTHNSKYY 307
gi 405976942  774 DYVpGGDLMGLLIKfgIFKEDLAQCYIAELVLAIESVHKMGFIHRDIKPDNILIDkdGHIKLTDFGLCTGFRWTHNSKYY 853
gi 340375485  472 EYIpGGDMMSLLIKlgTFPEHLTLFYIAELVCAIESVHKMGFIHRDIKPDNILIEadGHIKLTDFGLCTGFRWTHDSKRY 551
gi 339248899  558 EYIpGGDMMALLIKkgIFEESLARFYIAELVCAIQSVHKLGFIHRDIKPDNILIDrnGHIKLTDFGLCTGLRWTHDWKYY 637
gi 459176910  103 DYIpGGDLMSLLIKkeIFDQTLARFYTAELTLALESVHKMGFIHRDIKPDNILIDrdGHIKLTDFGLCTGFRWTHDSKYY 182
gi 360044130   82 EYIpGGDMMSLLIKkgIFEEPLARFYIAELTLALQSVHAMGFVHRDIKPDNILINreGHIKLTDFGLCTGFRWTHSSKYW 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                    ######               
gi 52783106   863 qsgdhprqdsmdfsnewgdpss------------crcgdrlkplerraarqhqrcLAHSLVGTPNYIAPEVLLRt----- 925
gi 17509105   660 gpendhhrvdsfslppeva------------------aidksvkvlnvrqqtrriTAHSLVGTGNYMAPEVIAKt----- 716
gi 427779909  476 qkngeharqdsmepdknwsed--------------cqcsrskplerrrrrehqrcLAQSLVGTPNYIAPEVLARh----- 536
gi 260784234  196 qpkdghirqdsmeppegwslen-----------cqcsykglkplerrqarqhqrcQAHSLVGTPNYIAPEVLLRr----- 259
gi 443698435  308 qkgekpavpflqcfmtvstadgsharqdsmepdetwglppnhdteerrrkrqkrgMAHSLVGTPNYIAPEVLCKs----- 382
gi 405976942  854 qkdglhprqdsmdvscameve-------------crcneilkplerrrqrerhrcLAHSLVGTPNYIAPEVLLRe----- 915
gi 340375485  552 qpkgssghtrqgsiepdtsawg------------dqctcpmkpleirrlkehhrcVAHSLVGTPNYIAPEILRRv----- 614
gi 339248899  638 aeeptipghshqdsfdllkq----------------qephsqykvlhyrnqkkrcQAHSLVGTPNYIAPEVLLRtvtttt 701
gi 459176910  183 tkdghsrqdsmdfshews-------------------nvplkpldlrrwrdanrhVARSLVGTPNYIAPEVLLRe----- 238
gi 360044130  162 dldfnipctspslhh-------------------------dktlerrrnsfanrrCAQSLVGTPNYIAPEILRRq----- 211
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                  #     #  #                                             
gi 52783106   926 ---------GYTQLCDWWSVGVILFEMLVGQPPFLAQtPLETQMKVINWQTSLHIPPQaklSPEASDLIIKLCRGPEDRL 996
gi 17509105   717 ---------GHNQSCDWWSTGVILYEMVFGRVPFHDDtPGGTQHRIKNWRNFLDFTYCgnlSKECLMMIQQLICDASSRL 787
gi 427779909  537 ---------GYGQSCDWWSVGVILYEMLVGQPPFLANtPGETQYKVLNWETTLQIPKLallSTESTDLILRLCCGAEQRL 607
gi 260784234  260 ---------GYTQLCDWWSVGVILYEMLVGQPPFLATtPAETQMKVINWDHYLAIPAQarlSRAASDIILKFCCDAENRL 330
gi 443698435  383 ---------GYTGCCDWWSVGVILYEMLVGQPPFYATsAAETQLKVINWKTELKIPAEanlSSAGADIIRQLCCDASTRL 453
gi 405976942  916 ---------GYTSCCDWWSVGVILYEMLVGQPPFYANtPAETQWKVIHWDETLKIPAEanlSEAAKDLIIKLCCSADKRL 986
gi 340375485  615 ---------GYTQLCDWWSVGVIMYEMLVGQPPFMASaPADTQLKIVNWPEYLRIPHHaqlSTAARDLVLRFLSDPQDRI 685
gi 339248899  702 dhihpfylqGHTQLCDWWSVGVILFEMVVGHPPFLANtSEETQAKVIDWRNSLQIPPEaklSAVAKDLIVKLCCSQEYRL 781
gi 459176910  239 ---------GYTQMCDWWSVGVILYEMVVGSPPFHSDtPSETQLKVINYKKSLRIPHHaqlAPQTEDIIRRFCCDQGARI 309
gi 360044130  212 ---------DYGQACDWWSVGVILYEMLVGQPPFLAQtAADTQIRVVQWYNYLKLPGEprlKKDASNLIRQLLRDPSDRL 282
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 52783106   997 Gkn------gADEIKAHPFF-KTIDFSSdl-rqQSASYIPKITHPTDTSNFDpvdpdklwsddneeenvndtlngwykng 1068
gi 17509105   788 GshgkdvaerTAQVKNHPWF-RGIDWVNlrklrADYIYIPRVTHDEDTSNFEtfqdndrad--------------kpnvr 852
gi 427779909  608 Grn------gADEIKAHPFF-ASIDFEGgl-rnKPAPYIPNIRYPADTSNFDavddtvldkpp---------paapepng 670
gi 260784234  331 Gkk------gVQEIKAHPFF-NHIPWEKgl-rkTKAPYAPYIRYPTDTSNFDpvdpervrssdseep--ervdatspsng 400
gi 443698435  454 Grn------gATEVKQHPFF-TGIEFEGlr--qQKAPYIPTIRHDTDTSNFDpvdpeklredsl--------qkdwadns 516
gi 405976942  987 Grn------gATEIKRHPYF-KDINFEGlr--kSQPPWKPKIKHAMDTSYFDeidgkfdddsdee-----mqkpdhping 1052
gi 340375485  686 Grn------gADEIKHHPFFtSRIDWDVgi-rnYVAPYKPKIMYEGDTSNFDpvpqsqvqkmykq------atptevmpq 752
gi 339248899  782 Gke-----ndAQDIKSHPFF-EGINWNNlr--kTKAPYRPQLLGDTDTSNFDpveprpqss-------------nsemsp 840
gi 459176910  310 Gck-----ggAEEVKKHEFF-AGITWEKlr--qMKAPYIPEIKFSEDTSNFDlppggdsffnvgke----atlnngtlkl 377
gi 360044130  283 Sd--------PVKIKSHPFF-ESVAWDKlv--qETPPYVPTIRDELDTSNFDpvddertlyssgn------nhsldysst 345
                         410
                  ....*....|....*.
Feature 1                         
gi 52783106  1069 khpEHAFYEFTFRRFF 1084
gi 17509105   853 glhNPAFYEFTYRHFF 868
gi 427779909  671 rhpEHAFFEFTFRRFF 686
gi 260784234  401 mlpEHAFYEFTFRRFF 416
gi 443698435  517 khsEHAFLEFTFRRFF 532
gi 405976942 1053 khpEHAFLEFTFRRFF 1068
gi 340375485  753 dhpEHAFYEFTFIRFA 768
gi 339248899  841 nvsDHAFYEFTFRRFF 856
gi 459176910  378 gpgEHAFFEFTFRRFF 393
gi 360044130  346 nntQLPFPNFTFKRFF 361

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