Conserved Protein Domain Family
STKc_RPK118_like
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cd05576: STKc_RPK118_like 
Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RPK118 contains an N-terminal Phox homology (PX) domain, a Microtubule Interacting and Trafficking (MIT) domain, and a kinase domain containing a long uncharacterized insert. Also included in the family is human RPK60 (or ribosomal protein S6 kinase-like 1), which also contains MIT and kinase domains but lacks a PX domain. RPK118 binds sphingosine kinase, a key enzyme in the synthesis of sphingosine 1-phosphate (SPP), a lipid messenger involved in many cellular events. RPK118 may be involved in transmitting SPP-mediated signaling. RPK118 also binds the antioxidant peroxiredoxin-3. RPK118 may be involved in the transport of PRDX3 from the cytoplasm to its site of function in the mitochondria. The RPK118-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Links
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Statistics
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PSSM-Id: 270728
Aligned: 5 rows
Threshold Bit Score: 359.938
Created: 28-Sep-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:active site [active site]
Evidence:
  • Comment:Based on the binding of peptide substrates and ATP analogs to the AGC kinases, PKA and PKB.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               #####   #            # #                       #               ## #   # # 
Q96S38        335 EELKAFRVLGVIDKVLLVMDTRTeQTFILKGLRKsseysRNRKTIIPRCVPNMVCLHKYIISEeSVFLVLQHAEGGKLWS 414  human
CAG09166      386 EELRAYRVLGIIDKVLLVMDKMTqETFILKGLRKssdcgRIKRTIVPHSVPHMVQLRKFIVSEdAVFLLLQYAEGGKLWS 465  Tetraodon nig...
Q9Y6S9        148 EQLRGCRVVGVIEKVQLVQDPATgGTFVVKSLPRchmvsRERLTIIPHGVPYMTKLLRYFVSEdSIFLHLEHVQGGTLWS 227  human
EMC90017      294 EELKAFRVLGVIDKVLLVMDTRTqQTFILKGLRKsseysRSRTTIIPRCVPNMVCLHKYIISEeSVFLVLQHAEGGKLWS 373  domestic pigeon
XP_002934734  333 EELKAFRVLGVIDKVLLVLDTKTqETFILKGLRKse-hcATRKTIIPRCVPNMVCLREYIISEeSVFLVLQHAEGGKLWN 411  western clawe...

Feature 1                                                                                         
Q96S38        415 YISKFLNrspeesfdikevkkptlakvhlqqptsspqdsssfesrgsdggsmlkalplkssltpssqddsnqeddgqdss 494  human
CAG09166      466 HIGKYLRsssqegsfdipfiqkshtaairspqqafpplgadsissgsapvacpdpaselqkqescspslqktaplarpde 545  Tetraodon nig...
Q9Y6S9        228 HLLSQAHsrhsglssgstqermkaqlnphlnlltparlpsghapgqdrialepprtspnlllageapstrp--------- 298  human
EMC90017      374 YVSKFLNrspeesfeiperrtssstkiyleqptpspkemgssadsrdsygesmlkvvplkssltpssqddssnqedgqes 453  domestic pigeon
XP_002934734  412 YLSKFFSisaeesfdippskssnsdedllkhlapcskssldsrgssdrnmlsvqplqssftlssqddsstqdeegrespl 491  western clawe...

Feature 1                                                                                         
Q96S38        495 pkwpdsgssseeecttsyltlcneygqekiepgslneepfmktegngvdtkaiksfpahlaadsdspstqlrahelkffp 574  human
CAG09166      546 esdsgamseeeftnsylalcneyeqekvnadvleeqeersekevlslevpmgtattssrsrsllsndslsspissqelgf 625  Tetraodon nig...
Q9Y6S9            --------------------------------------------------------------------------------      human
EMC90017      454 skwldsgssseeecttsyltlcneygqekidsgslneepvvkleseglntkersslqkcsvvgsdsftsqvasqerklfi 533  domestic pigeon
XP_002934734  492 kwadsasssdeecttsyltlcreysqekvepdtisvepllsldeqgdtpqdfidleephcttynalksqmtceeplfnde 571  western clawe...

Feature 1                                                                                         
Q96S38        575 nddpeavssprtsdslsrsknspmeffridskdsasellgldfgeklyslkseplkpfftlpdgdsasrsfntseskvef 654  human
CAG09166      626 fpesskcggecrddgqdqgdvfsplpspavpltldqskhtpmeffridskdstgevnfldlgeqhisqksvpifstsdlg 705  Tetraodon nig...
Q9Y6S9            --------------------------------------------------------------------------------      human
EMC90017      534 ddteseiasptrildsltrsknspmelfridskdstsellgldfgeklynlkseplkplfsvpdhdrsldale------t 607  domestic pigeon
XP_002934734  572 sghsapkpimmadalrksrdspmeffridsresnsdfgdhgskagtvepyppfqddlddnefe----------------- 634  western clawe...

Feature 1                                                                                         
Q96S38        655 kaqdtisrgsddsvpvisfkdaafddvsgtdegrpdllvnlpgelestreaaamgptkftqtnigiienklleapdvlcl 734  human
CAG09166      706 sdvtegppelaqevglhsgglwgldcsdkgsndsvpvisfkeaavedeghppdllvnlpvpsgavhssqeeldtsgvipg 785  Tetraodon nig...
Q9Y6S9            --------------------------------------------------------------------------------      human
EMC90017      608 kmgvrahdtvsrgsndsvpvisfrdaalddvnsvdegrpdllinlpgmsdeteeaamsrptkftktdrdmlevkllekpd 687  domestic pigeon
XP_002934734  635 --------perphvgtsvkithdaisrgsndsvpvisfkdaalddicsidegrpdllvnlpgteqmdetqvvfqnnilet 706  western clawe...

Feature 1                                                                                         
Q96S38        735 rlsteqcqaheekgieelsdpsgpksysitekhyaqedprmlfvaavdhsssgdmsllpssdpkfqglgvvesavtannt 814  human
CAG09166      786 leaeaspqkftqpdvlqlliqpeeeqelpslhtasatcdtsaasssissmledcsvalgqektyqiltcdaarqdvdlpl 865  Tetraodon nig...
Q9Y6S9            --------------------------------------------------------------------------------      human
EMC90017      688 vlqlnnsaepckafdqeldhvapevgdssheaahgqsgvpqgalgtlftseqevgssedgtlfqglgdcslnvaskeesl 767  domestic pigeon
XP_002934734  707 diiepklletpdvllvnnsleqltgldanpletveqiieqcqvnannkessasapieplesrgalsdldtllpasltfpl 786  western clawe...

Feature 1                                                                                         
Q96S38        815 eeslfricsplsganeyiastdtlkteevllftdqtddlakeeptslfqrdsetkgesglvlegDKEIHQIFEDLDKKla 894  human
CAG09166      866 tdpfneqhengtnvnaspgshpgggsrsfsrstseaeahaaqqsspglhdeppravcgprgsefDKEVSRLFAQLDELsl 945  Tetraodon nig...
Q9Y6S9        299 -qreaegeptartstsgssdlpkapgghlhlqarragqnsdagpprgltwvpegagpvlggcgrGMDQSCLSADGAGRgc 377  human
EMC90017      768 lvssqlsgaqdvsldgdvlrneavllfsdqtedfgkegadpsvlsaaeskktapkredkiavagEKEIHQIFQDLDERla 847  domestic pigeon
XP_002934734  787 pystdtegisqvpcesssdvknvcgpqetlplansdeltstlvqlkikiedtdaaidgkrefreEKEIHKLFQELDAKls 866  western clawe...

Feature 1                                           # # ## #         ##  #          ######        
Q96S38        895 lasrFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNdrGHIQLTYFSRWSEVEDSCDSDAIERMYCAPEVGA 974  human
CAG09166      946 aasqARIPEELVKCWAAEMTTALDSLHQEGIVCRDLNPNNILLDhqGHVQLTYFCSWVDVAESCDREAVSNMYCAPEVGG 1025 Tetraodon nig...
Q9Y6S9        378 gratWSVREEQVKQWAAEMLVALEALHEQGVLCRDLHPGNLLLDqaGHIRLTYFGQWSEVEPQCCGEAVDNLYSAPEVGG 457  human
EMC90017      848 vtsrFYIPEDCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNdrGHIQLTYFSRWREVEDSCDNDAIERMYCAPEVGA 927  domestic pigeon
XP_002934734  867 aasnVIIPETCIQRWAAEIVLALDALHGEGIVCRDLNPNNILLNdrGHIQLTYFSRWSEVEDSCDSDAIEKMYCAPEVGG 946  western clawe...

Feature 1                           #     #  #                                                    
Q96S38        975 ItEETEACDWWSLGAVLFELLTGKTLVECHpAGINTHTTLNMPEcvsEEARSLIQQLLQfnPLERLGAGVAGVEDIKSHP 1054 human
CAG09166     1026 IsEETAACDWWSLGAILFELLTGTSLLRCHpAGIGRHTTLNIPEfvsEEARSLLEQLLQfnPVERLGAGGAGVDEIKSHP 1105 Tetraodon nig...
Q9Y6S9        458 IsELTEACDWWSFGSLLYELLTGMALSQSHpSGIQAHTQLQLPEwlsRPAASLLTELLQfePTRRLGMGEGGVSKLKSHP 537  human
EMC90017      928 IlEETEACDWWSLGAILFELLTGKPLVECHpSGINTHTSLSIPDhvsKEARSLIQQLLQfnPAERLGAGVAGVEDIKSHP 1007 domestic pigeon
XP_002934734  947 IsEETQACDWWSLGALLFELLTRKALAECHpAGINTHTTVSVPEyvsKEARALVQQLLQfnPMERLGAGVAGVEDIKSHP 1026 western clawe...

Feature 1           
Q96S38       1055 FF 1056 human
CAG09166     1106 FF 1107 Tetraodon nigroviridis
Q9Y6S9        538 FF 539  human
EMC90017     1008 FF 1009 domestic pigeon
XP_002934734 1027 FF 1028 western clawed frog

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