Conserved Protein Domain Family
Peptidases_S8_4

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cd05561: Peptidases_S8_4 
Peptidase S8 family domain, uncharacterized subfamily 4
This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.
Statistics
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PSSM-Id: 173797
View PSSM: cd05561
Aligned: 21 rows
Threshold Bit Score: 170.162
Threshold Setting Gi: 85373440
Created: 26-Sep-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active sitecatalytic triad
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              #                                     #                                   
NP_435320    212 VRIGLVDTAINPDHlafe----arniEIVRLveeel--pesgRQHGTAVAALLVgsassr-tpglipGGKLIAVDafhrg 284 Sinorhizobium m...
ZP_01035322  219 VTIGMIDTGINTDHavl------agaQVALLrvapedytasdAIHGTAVAALLVgdpasr-apgllpGLPLVAVDafhka 291 Roseovarius sp....
ZP_01104695  380 LRVGMIDSRVDTAHpal------aqsRIHTRsfarp-gaespDFHGTAIASIIAansaey--qglapMAEVYAASvfeld 450 Congregibacter ...
NP_105834    145 IRVAVIDTGIDDTNpal-------agVIAAQfdampgvpvekRDHGTSIDGLIAgvgal---egmapGARIYHARafeg- 213 Mesorhizobium l...
ZP_01613650  200 VKIGMIDSAINTKHsaf------kgaNITTQsflpq-glsspNLHGTAIAGLITgkgakl--spllgNAKLYSAEvfyrq 270 Alteromonadales...
YP_561580    217 ITLGMVDTAISPHHsalt----qtaqFALLQrsflaegiaisYAHGTAVAGVLAgrdkql--npllsSLTLLNAGafyaq 290 Shewanella deni...
ZP_01903596   92 PRIGMIDTGINQNHsal------sgqDLTIHqadlggreaagRKHGTAIAAMLIgklddr-vpgllpNASLVAVEafhrg 164 Roseobacter sp....
ZP_01893448  207 VRVGMVDTSIATDHrvfesaqvvqerFLALAevdgt--ltepAIHGTAVASLLVgnrpgq-wparlpQATIFNASvfydr 283 Marinobacter al...
ZP_01306322  248 MRIGMMDSAIQSNHicf------qrdKVKQKtftps-aaqqdYQHGTAMASAINqcg-------llsSVELFNAEvfart 313 Oceanobacter sp...
YP_001534755 250 VRVGLIDGPLDLRTpsl------tnvRVTSLsvlrprerpgsTAHGTGIAALIAgqattqgpaglapGAELLSVVafara 323 Dinoroseobacter...
Feature 1                   #                  #                            #                    
NP_435320    285 erqddrsaAFDLARALDLLTRRQVQVINLSLAGPPNLLLEQAVMKAGERG-IIMVAAAGNDGPKAEPVYpaAYEEVIAVT 363 Sinorhizobium m...
ZP_01035322  292 s-gderadAFTLVRGLDHLVEAGATVINLSLTGPANAVLEQTLAELESAEgIVVVAAAGNGGPNAPPAYpaAYDSVIAVT 370 Roseovarius sp....
ZP_01104695  451 gkrgeiasTVSLIRALDWLISSGVDVVNISLAGPPNRLLERALDRASSQD-MVVMAAAGNGGPVARPMYpaAYDSVVAVT 529 Congregibacter ...
NP_105834    214 ----gkstMDVILSALDWAAEQNVSIINMSFVGPKNDLLGAACRNARALG-MVLVAAAGNNGPKAPYGYpaAFDGVIAVT 288 Mesorhizobium l...
ZP_01613650  271 seyaqgatLFAIVEALNWLVSNKIPVINMSLTGPNNAVLEASITAAIKQN-VLIVAAAGNQGPASQPLYpgAYKSVIAVS 349 Alteromonadales...
YP_561580    291 nayqqgasLESILQALNWLVSEGVRVVNMSLTGPDNPVLQQVVTGLAEQG-TVLIAAAGNGGPAAAPLFpaAYPQVIAVT 369 Shewanella deni...
ZP_01903596  165 y-ygeqadVFSLARAFDILLAADVSVVNMSFSGPRNLVLEDLVVRAHERG-VALVAAAGNGGPGAEAAYpaAFESVLAVT 242 Roseobacter sp....
ZP_01893448  284 drtlsgatLGHLLEGLNWLAGQDLSVINISLTGPDNQLLAAAVSRLRERG-VLMVAAVGNQGPSAPPLYpaAYTEVIGVT 362 Marinobacter al...
ZP_01306322  314 pkglviasAADLIKGLNWLLKQKVQAINLSLSGPPNQVLARVLKNVMERG-TVIIASVGNEGAAAFPRYpaAQSGVIAIT 392 Oceanobacter sp...
YP_001534755 324 g-grdlarLENIALGLDWLVERGADVVNMSLAGPPNEALAALVEIADQQG-LIMVAAAGNRGEPSLGYPa-ADPRVLAIT 400 Dinoroseobacter...
Feature 1                                                  #                                     
NP_435320    364 ATDRRKRPYRRAGRGEHIDFAAPGVAvwtaasVSGARPKTGTSFAAPFVTAAVAMMkasepdlapemIHSRLSGHAEDLG 443 Sinorhizobium m...
ZP_01035322  371 AVDKAGGPYRRAGRGPHVHLAAPGVEvwtaasVKGARWKTGTSFAAPYVTAAVALWqqthpgsspaeIRAALAQSAVDLG 450 Roseovarius sp....
ZP_01104695  530 AVDSAQQVFRLANRGDYLALAAPGVDlrhaqpGGGYAASSGTSFAVPFAVTAAARLsrls---pesdIITMLLESAMDLG 606 Congregibacter ...
NP_105834    289 ATDAKDALMPQANRGAYVFISAPGVEmva-psGAGSDVVTGTSFAAAIVSGAIANLlhaspgrtaddIEKALAATAKDLG 367 Mesorhizobium l...
ZP_01613650  350 AIDSKNQIYRWSNKGDYIDFAALGVNvvtsqgNGKFGRESGTSMAAPHVSAALSCLllkhg-nnktkALNELTSLAVDLG 428 Alteromonadales...
YP_561580    370 AVDKRLELYRWANQGDYIDFAALGVKvlttraDGSIGMESGTSMATPVVTAKIACLlaakpeldlsqIVQQLQQQVVDLG 449 Shewanella deni...
ZP_01903596  243 AVDHNQRVYRQANQGPYINFAAPGVRvwtaasISGGRLKSGTSYAAPFVTASLAVQrlrtpsleleqTISEMARCAKDLG 322 Roseobacter sp....
ZP_01893448  363 AADRSGKLYRWANRGEQVMFASSGVTvpvahpDAGMVADSGTSLASPVVAAALACQrnel---sedkAVGALINAAKDLG 439 Marinobacter al...
ZP_01306322  393 AIDKNLNVFEKAVRGTHVDFAVPGVSilladpNGEYTIKTGTSVANAVATPIILHSlqs------gkTLQSLKSNTKDLG 466 Oceanobacter sp...
YP_001534755 401 AIDADKRIYRRASFGAGMDFSAPGVDiav-pdRRGWSYRSGTSYAAAVATGLVAQKlaqqr-lttdqLRASFRRSAEDLG 478 Dinoroseobacter...
Feature 1                   
NP_435320    444 DPGKDAVFGWG 454 Sinorhizobium meliloti 1021
ZP_01035322  451 EAGTDDIFGHG 461 Roseovarius sp. 217
ZP_01104695  607 PPGRDTIYGYG 617 Congregibacter litoralis KT71
NP_105834    368 PKGRDNDFGYG 378 Mesorhizobium loti MAFF303099
ZP_01613650  429 EQGKDTTFGYG 439 Alteromonadales bacterium TW-7
YP_561580    450 VPGKDPLFGHG 460 Shewanella denitrificans OS217
ZP_01903596  323 EAGRDPVFGHG 333 Roseobacter sp. AzwK-3b
ZP_01893448  440 RPGRDTEFGHG 450 Marinobacter algicola DG893
ZP_01306322  467 EKGKDKIFGYG 477 Oceanobacter sp. RED65
YP_001534755 479 PSGYDPRFGWG 489 Dinoroseobacter shibae DFL 12

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