Conserved Protein Domain Family
POLBc_B2

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cd05531: POLBc_B2 
DNA polymerase type-B B2 subfamily catalytic domain. Archaeal proteins that are involved in DNA replication are similar to those from eukaryotes. Some archaeal members also possess multiple family B DNA polymerases (B1, B2 and B3). So far there is no specific function(s) has been assigned for different members of the archaea type B DNA polymerases. Phylogenetic analyses of eubacterial, archaeal, and eukaryotic family B DNA polymerases are support independent gene duplications during the evolution of archaeal and eukaryotic family B DNA polymerases.
Statistics
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PSSM-Id: 99914
View PSSM: cd05531
Aligned: 15 rows
Threshold Bit Score: 381.691
Threshold Setting Gi: 14424453
Created: 25-Jul-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
metal-bindingactive site
Feature 1:metal-binding site
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
NP_111564    270 LIKRDRGGLVFQPV---PGIYRDVYEIDFSSMYPSIIVKYNLSPGNV--------------------------KFLPEAL 320 Thermoplasma vo...
YP_001839538 356 LLNADKGGLVFQADiqnGFVLENVAQLDFSQMYPNIMVKHNISPETInclcceddpnvekvpslgyricakrkGIVSEAL 435 Leptospira bifl...
EAY57271     356 LLETDKGGMVFLPP---PGFHESVAELDFASMYPSLMVRFNISPETVgcsccpgsrap----gtrhtictrrsGFIPEVL 428 Leptospirillum ...
ZP_02937676  336 LIKIDKGGLTLKPL---VGLFENVAEYDFFSMYPSIITNYNLSYETInckhpeckktlp---ytnyrictkkiGIVPQTL 409 Sulfurihydrogen...
Q07635       320 IMMVDKGGLILFPQ---PGCYDNVYQVDFSSMYPSLIVKHNISAETVeacddikte--------lhsiclkekGIIPEAL 388 Sulfolobus solf...
NP_148473    281 LVESDMPGAARLPE---PGVYWGVVQLDYSSLYPRLIAMYNISAETVdtpcgntldpap--gygghrvcmdrrGLVPEVL 355 Aeropyrum perni...
YP_001191525 257 LLLNDKGGLVLFPR---TGCFDDAWQVDFSSMYPSLIVKHNISGETVdacddvvtei-------ghticnserGIVPEAL 326 Metallosphaera ...
YP_001404414 314 LQAADRGGLMFQPV---PGTYESVDEIDFTSLYPTIIVNENLSPETLghn--------------------drpGFLPAVL 370 Candidatus Meth...
NP_395847    319 LHDADRGGFIFAPE---VGLHENVHELDFSSLYPNIICTRNVSPDVIrcdchsdrddv----pglgysicddrGYLVDVL 391 Halobacterium s...
YP_502310    320 MRLDYRGGYILQPP---PGIFADVTQIDFTSFYPSIIVSENLSPETLndr--------------------tkpGFLSSVL 376 Methanospirillu...
Feature 1                                                                                        
NP_111564    321 NGLLERRLFYKRISASsevy-----------snrNAALKWLLLTSFGYTGYKNAKFGKIEVHEDITEIGRKLLADAISIA 389 Thermoplasma vo...
YP_001839538 436 AHIVQRRNHYKEQKRNnhpnll-------niqskQSSLKWMLVTSFGYLGYRNAKFGKLESHEAVTAFGREKLINAKEVS 508 Leptospira bifl...
EAY57271     429 APLLEKRQTYKDRLANrsvpdkk----tdpdnlrQKALKWLLVVSFGYLGYKNARFGRIEAHECVTAYGREVLLKAKEMA 504 Leptospirillum ...
ZP_02937676  410 KWLLERRLKYKQLLKKeknqi---------ydnrQKALKWLLVVSFGYLGYKNAVFGRIESHEATTSIGRQLITFVKEIL 480 Sulfurihydrogen...
Q07635       389 QWLIERKSELKKIDEEr-----------------AEAIKWILVASFGYLGYRNSLFGKIEAYEMVTYLARKTLRRTMEIA 451 Sulfolobus solf...
NP_148473    356 GRLVDLREEARRRGAGe----------------eQEAIKWILVSGFGYLGFRNSLFGSIAAYETVTAAARRALAAAEEAA 419 Aeropyrum perni...
YP_001191525 327 SWLIRRKEALKPVDPEr-----------------AEAIKWILVASFGYLGYRNSKFGKIEAYELVTYYARKTLRRALEIA 389 Metallosphaera ...
YP_001404414 371 DPVIGLRRTTKRQKKTdprl-----------rgpDAILKWMLVTCFGYTGYRNAKFGRIEVHEAITAASREILLRTKEIA 439 Candidatus Meth...
NP_395847    392 QPIIDARDEIKAAIRRetdrddpdedrlaelegrSGALKWILVACFGYQGFSNAKFGRIECHEAINAFAREILLMAKQRL 471 Halobacterium s...
YP_502310    377 EPVITLRQHTKQMKKTdpsy-----------agmDGVLKWMLVTCFGYTGYKNARFGRIEVHEEITRAATRILKDCVKLT 445 Methanospirillu...
Feature 1                  # ##                                                                  
NP_111564    390 HDHGFEMIHGIVDSLWISg--------------nGDIEEVIREIRERTMVDiv--vSGHYRWIVFLPENDg--SGSPSRY 451 Thermoplasma vo...
YP_001839538 509 EEFQYKVVHGITDSIFIQkkdtt-------pitnEDLTFLCLEIEKRTKIKme--iEGIYSWLCFPPSTQdekLPVANRY 579 Leptospira bifl...
EAY57271     505 EDRGFRVLHGIVDSLWLQkqg----------mtqDVCEELAREIGKETGIPln--lEGIYRWIGFFSSRTspsIAVPNRF 572 Leptospirillum ...
ZP_02937676  481 EAKGFRVIHILTDSIWVYkhdytiddykkmeeylNKRINEKFIPVNPDGIPfkillEGVYDWIVFLPSKSn-sVGVSNRY 559 Sulfurihydrogen...
Q07635       452 EEMGLRVLHGIIDSLVVKg---------------DNVDKFIEKVEKETGLRl---dYKRYNWIIFTITRNn--TPYPTRY 511 Sulfolobus solf...
NP_148473    420 VEMGYRVIHSLVDSVFIQpve-----------prGPPGEVAREIERRTGVPvk--iEAEYKWLYIPPTLRg--HGAVNKY 484 Aeropyrum perni...
YP_001191525 390 QEIGVEVLHGIVDSLVIR----------------GDAPQLVRRLEEETGLHl---rSTRLKWIVLGGRRDg--LPYPMRY 448 Metallosphaera ...
YP_001404414 440 EEMGFTVLHGIVDCLWVQg---------------NLPIETLRERIERETRYpi--dAEHFDWIVFLPLADg--FGAYNRY 500 Candidatus Meth...
NP_395847    472 EAGGWRVVHGIVDSIWVTpdpdv------deedrEDLQTLATEITERVEIRle--hEAHYDWVAFVPQREs-dAGALTKY 542 Halobacterium s...
YP_502310    446 EAHGGKVLHAIIDCLFIR----------------GGHAGTIQEEIERMTTFht--eADTYDWVVFLPQSDg--SGSYCSY 505 Methanospirillu...
Feature 1                                                                                        
NP_111564    452 YGLdy-nGSYKVRGieLRRADAPEICKRFQVEALEVLREcrTVEDVMSSKAKIeaLEHRYIKNIrrfp--lnyfTISKKI 528 Thermoplasma vo...
YP_001839538 580 MGRfi-dGQFKGRGiiTRRKDFPNFIKDAQNKMIQWMCQfkSISEMQKKESEIlnLFFYYDQKLttgnlnwkdlVIQKST 658 Leptospira bifl...
EAY57271     573 LGVfe-tGEIKVRGleIRRKDAPPFVRKVQQRMLDILAQaeNMEEYRRLIPKArnVVEEALEVLsegrvplsqlVFRKTL 651 Leptospirillum ...
ZP_02937676  560 FGKfs-nGEFKFRGidLRRRDVPEFIKNFQLEVFEHLGKakNKTEFLKLIKDIdeIFDKHKQKLmegdfslkdlIIKKKV 638 Sulfurihydrogen...
Q07635       512 IANm--nGEMIAKG--LIRENMPNIVKSFLEDVLREFSSakTCSDVKKLRIRD--LFEHYRKRA----------INGEPI 575 Sulfolobus solf...
NP_148473    485 YGAle-sGGVKLKGiaAVRRDTPEIVREAQASAIARLAEarHPGEWPGAVERAwkVVDGYMRLLregeppveklVIEKRV 563 Aeropyrum perni...
YP_001191525 449 FGMt--eEGMKYKG--IIRRNMPNLVRDFLESSMNILSRaeTCEDLKRLRSNLleNLREYEERVi---------HGEPRD 515 Metallosphaera ...
YP_001404414 501 YGKls-dGHIRVRGiaARRHDTPPFIKEVQCRMLGVMKRaaTIAELEETKEEAeqIFREAILALpaad--pqqmAIGRRI 577 Candidatus Meth...
NP_395847    543 FGKvagdDDFKVRGieARQRSTPPFIEDVQRDCLDRLDAtrSPDAVLGRLERAidELQAGNVAVerlv---ernRVSKPL 619 Halobacterium s...
YP_502310    506 FGRlk-tGKMKVKGvsTNRRTTPPYVVRMQNEMFDILGTyqEIDGIPDARDTLysVYRRYLDTMnhad--lrdfIITRRI 582 Methanospirillu...
Feature 1                                                                                        
NP_111564    529 trhsseysvntvtr-salkaaetfgkvsLGQIIKYTVSDESrkivn--------ldddGTIDYRYYERCl-rRAFQPFDF 598 Thermoplasma vo...
YP_001839538 659 skepedytvdapstiavkdllamgvhvqAGEKIKYIVINQKsdk------------kgERYLTLERMEQk-eNPKKQIDD 725 Leptospira bifl...
EAY57271     652 srspaeferatitaivsrellgrgvrlaAGETVHYVLTDVRnrdpaerarawpvhtpdVTYDRKKYRELi-lRAAEPLLN 730 Leptospirillum ...
ZP_02937676  639 skdsssyqkrtdlsevagtllkegfnlnPGESVNIIYILDKyikampl---eiyltnpKPINIEKYLKMleeSKIGLLPK 715 Sulfurihydrogen...
Q07635       576 dyviwi----------------kdvpyvRGIKGFYEARLGY-----------------MGRDVNYYINYl-kRVYEDVEE 621 Sulfolobus solf...
NP_148473    564 dpgssrntpw---------rrawlkspvQTPTVKYVVAGGGrphpv-------wlgppGSIDRQYYMKLl-eRAAGELPK 626 Aeropyrum perni...
YP_001191525 516 fvmwvk-----------------gepyvRGVRGFYNARRGF-----------------MGRDTKYYLEYl-rRTAREVLG 560 Metallosphaera ...
YP_001404414 578 srlvyrhrclega--avqayrdqgielsPGMQIRYVVEDARhyrvv-------pagsaISFDTAFYRTLl-eRAGEEILA 647 Candidatus Meth...
NP_395847    620 egysqntqnvaa----lkrareqdlavhPGQDIEYVVVDDEkssrdrv---alaheaiETYDTSYYETQl-vRAVESVLS 691 Halobacterium s...
YP_502310    583 gkhtynkqciaqa--vldtykehhvtiePGMDASFLVRDEKrlivd-------pswdaQGIDTRYYKRLl-dKAYEEVVS 652 Methanospirillu...
Feature 1          
NP_111564    599 IF 600 Thermoplasma volcanium GSS1
YP_001839538 726 KN 727 Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)'
EAY57271     731 PR 732 Leptospirillum sp. Group II UBA
ZP_02937676  716 KL 717 Sulfurihydrogenibium sp. YO3AOP1
Q07635       622 VM 623 Sulfolobus solfataricus
NP_148473    627 PV 628 Aeropyrum pernix K1
YP_001191525 561 IG 562 Metallosphaera sedula DSM 5348
YP_001404414 648 AY 649 Candidatus Methanoregula boonei 6A8
NP_395847    692 PL 693 Halobacterium sp. NRC-1
YP_502310    653 ML 654 Methanospirillum hungatei JF-1

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