Conserved Protein Domain Family
Bromo_WDR9_I_like

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cd05529: Bromo_WDR9_I_like 
Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.
Statistics
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PSSM-Id: 99958
View PSSM: cd05529
Aligned: 21 rows
Threshold Bit Score: 117.438
Threshold Setting Gi: 65304741
Created: 13-Sep-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative acetyllysine binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                         
Q9NSI6       1149 LYKPQAGEWGq---------------------kSRDEECDRIISGIDQLL--------------------NLDIAAAFAG 1187 human
AAF56278     1196 LYQPKSEEWHr---------------------gDRDGTCRRIINGLEQVM--------------------RLSIAEHFLA 1234 fruit fly
XP_972653     999 LYQPTADDWPn---------------------sDREAVTCYILTGLAKVM--------------------ELAIAEPFLV 1037 red flour beetle
XP_650909     806 VSSNGSIDVSineidsdy--------tehrsddFADEVREILINKLREIV--------------------DNEDYQIFKT 857  Entamoeba his...
XP_638029    1705 KDNILRIKIQyv-------------------esIEDEKIENLKKEMKEFLe-------------------NDEITDIYSE 1746 Dictyostelium...
EAR90831     1712 LEGPNMIRIScwdviypirrtsspddypnddacLSKEETEQIFKLIQAVId------------------nQSEITCYFEE 1773 Tetrahymena t...
XP_001437931 1263 HKSNKSIEIQ-----------------------GASLQSALTTNEAQQINrdina-----------mikkQTKIAFFFSN 1308 Paramecium te...
CAL50311      584 LYNDELMRKEhakllsgast---srgpqktpfsNVDESSPSLTPGVTKELlsr---------------vlRLARNDRFEA 645  Ostreococcus ...
CAD98523     1457 IYETVPDKKSl---------------------pNNLEASNDLIKIFCWMTtqng-------------qnnPLSVVEFFKY 1502 Cryptosporidi...
CAI73066     1526 ISYDKKIKWVd---------------------cWNLDLNDEIKPKLEEVFgkikskglnqehkdkflnliQDPKYGIFEY 1584 Theileria ann...
Feature 1          #                  #  #                                       #   #     #      
Q9NSI6       1188 PVDLc--------------tYPKYCTVVAYPTDLYTIRMRLVNR-FYRRLSALVWEVRYIEHNARTFNEPeSVIARSAKK 1252 human
AAF56278     1235 PVDLn--------------iYPDYAYLIEYPIDLTTIKSRFENH-FYRRITSAQFDVRYLATNAEQYNRRhAIIVKHSRI 1299 fruit fly
XP_972653    1038 PVDLn--------------tYPTYAVIVEYPVDLSTIKARFENR-FYRRLTAAQFDVRHLAANAEKFNERhSIIVKHARI 1102 red flour beetle
XP_650909     858 PVDIr--------------mYPNYIPTCPFPIDFNLILQRLINDnYYRTYDQVEWEIFKLIRNAVTYNGPnSPIGECAIE 923  Entamoeba his...
XP_638029    1747 PVDLk--------------lYPLYIRFVPHPMDISTIIKRLESS-YYRSLDAIYFDAKLIMIDAYVYNKPnTMVAKNSKL 1811 Dictyostelium...
EAR90831     1774 AVNLk--------------kYKHYYEFVEFPMDISKIRRRLLNG-YYRSQQSIFHDINLIDSNAHKFNNPdSPICESSKR 1838 Tetrahymena t...
XP_001437931 1309 EVDVq--------------qYPEYLDYVPLMSYITLIQRRLEND-FYRSKDQILNDVERIRRNAYIFNPPkSEVCDLADK 1373 Paramecium te...
CAL50311      646 FVNVigpnekf---tradgtVTNYCSLVPVPMALNLIINRLKNS-YYRQIDGFRSDVELIRVNAEIFHGEgSVFANFAAE 721  Ostreococcus ...
CAD98523     1503 PIPFfskkniskngfsnqewVMHYWKEIPLPFSFTSIINRIRNN-YYRRLESLVFDIFLVRSNCEHFNINnNNLVQGIRS 1581 Cryptosporidi...
CAI73066     1585 VEEYglrs---------hewVYEYWRYIPRPISLNEIREKLRND-YYRTPKGVWAEIKLLISNCINFNETsSNYSKIARE 1654 Theileria ann...
Feature 1                     
Q9NSI6       1253 ITDQLLKFIKNQ 1264 human
AAF56278     1300 VTDLCLRIIREP 1311 fruit fly
XP_972653    1103 LTELCLRIIKQC 1114 red flour beetle
XP_650909     924 IAEELKPTLETC 935  Entamoeba histolytica HM-1:IMSS
XP_638029    1812 VFHRISDILKEA 1823 Dictyostelium discoideum AX4
EAR90831     1839 VKEILTSIVSNF 1850 Tetrahymena thermophila SB210
XP_001437931 1374 LANLLHSIVNGD 1385 Paramecium tetraurelia strain d4-2
CAL50311      722 LEDDLLDDLPST 733  Ostreococcus tauri
CAD98523     1582 IEYELLRLIFSK 1593 Cryptosporidium parvum
CAI73066     1655 VDVNLDNLMINM 1666 Theileria annulata

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