Conserved Protein Domain Family
Bromo_polybromo_VI

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cd05526: Bromo_polybromo_VI 
Bromodomain, polybromo repeat VI. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.
Statistics
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PSSM-Id: 99956
View PSSM: cd05526
Aligned: 10 rows
Threshold Bit Score: 155.988
Threshold Setting Gi: 156363502
Created: 13-Sep-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative acetyllysine binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                              #     #  #                                 
AAH98878      193 ASLVRELIRNLFVSMMghqd----degrCYSDSLAEVP-----AIDPANPDDPPLTLEIIRNNVDSGr-YRRLDVFQEHV 262  zebrafish
NP_001021008  822 APRVQVELRTIFTSIFaslfskkdeegkCYSDHLTEFTev--lKANGVPSSEWPFTLDQIKMNIDKCr-YRRLDKLQKDF 898  nematode
AAF56339      758 PLAVQELFLTLFTTIYnhqd----eegrCYSDSLAELPe---yDEIGEGPKVRGISLDLVKRRLDKGa-YKRLDVYQEDI 829  fruit fly
951231        773 TLLIQELIHNLFVSVMshqd----degrCYSDSLAEIP-----AVDPNFPNKPPLTFDIIRKNVENNr-YRRLDLFQENM 842  chicken
AAG34760      775 TLLIQELIHNLFVSVMshqd----degrCYSDSLAEIP-----AVDPNFPNKPPLTFDIIRKNVENNr-YRRLDLFQEHM 844  human
AAH84946      798 TLLIQELIHNLFVSVMshqd----gegrCYSDSLAEIP-----AVDPKFPKRPPLTFDIIRKNVENNc-YRRLDLFQEHM 867  African clawe...
XP_625055     780 SAAIQEILATIFTALYnhqd----eegrCYSDSMAELPe----HDIIDGKKIRGLSLDLIKRRLDRGv-YKRLDRFQEDV 850  honey bee
CAC70156      797 QSEVQALLASILISVNnhqd----sdgrCFSDSLADLPgm--lRRKGIDSVNIPFSIDEMKRSVDKGr-YRRLDKFQDDL 869  agent of lymp...
XP_001626082  733 SFLVQKLLMTLYSSVMqhvd----eegrCYSDSLAELTg---sDLVKLSKMDINFIIVFIVIFFTFQyqYHRLDKFQEDM 805  starlet sea a...
XP_796375     823 QGLVREIITSLFVSVAnhqd----eegrCYSDSLAEIPvdkdaMMDDPNLQKKPLDLDTIRRYLDRGc-YRRLDCFQDHI 897  purple urchin
Feature 1               #   #     #                     
AAH98878      263 FEVLEKARRLNRTDsEIFEDSVELQHFFVKIRDELCKN 300  zebrafish
NP_001021008  899 FDLFERARELSKAGsSMYEAACTLQKSFIVERDTRCKD 936  nematode
AAF56339      830 FACLERARKLSRTDsDIFQDSIELQTYFIRKRDELCKD 867  fruit fly
951231        843 FEVLERARRMNRTDsEIYEDAVELQQFFIKIRDELCKN 880  chicken
AAG34760      845 FEVLERARRMNRTDsEIYEDAVELQQFFIKIRDELCKN 882  human
AAH84946      868 FEVLERARRLNRTDsEIYEDAVELQQFFIKIRDELCKN 905  African clawed frog
XP_625055     851 FTCLERARRLSRTDsQPFEDSVELQAFFLRTRDEVTRG 888  honey bee
CAC70156      870 FFLFNAAMDHAHSDsQVFEDTVELWMYYLKTRDDLTRT 907  agent of lymphatic filariasis
XP_001626082  806 FSIFEKARKISHSDcEMYDDASELQVYFITQRDKLCKE 843  starlet sea anemone
XP_796375     898 FFVLERARQLSRTDsQVYEDSIEMQRFFIQIRDEICKN 935  purple urchin

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