Conserved Protein Domain Family
Bromo_Rsc1_2_I

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cd05521: Bromo_Rsc1_2_I 
Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.
Statistics
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PSSM-Id: 99952
View PSSM: cd05521
Aligned: 12 rows
Threshold Bit Score: 155.173
Threshold Setting Gi: 149244482
Created: 13-Sep-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative acetyllysine binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                        #    #  #                                      #
12230583      16 ALYKDLRKEYESLFTLKEDs-GLEISPIFNVLPPkkDYPDYYAVIKNPVSFNTLKKRIPh--YTDAQQFMNDVVQIPWNA 92   baker's yeast
XP_452120      6 PLKEVIKPLVNIIYELKEEn-GLEIHPIFHLLPPkrDYPDYYQIIEHPISLSTVRKRMTq--YKNPQEFVNDLARVTWNA 82   Kluyveromyces ...
XP_445094      6 ELQENLRPEYLRLYNVINEe-NVNISPVFTVLPPrkDYPDYYDVIKKPISINTLKKRLTt--YTNAQQFMDDLVHIPWNA 82   Candida glabra...
NP_982942      2 LLRDQLKVLLDGVFDLKEEn-GIEILPIFYTLPLrkDYPDYYRIIKKPLSLATVKKKLNh--YKRAQEFVNDLVRITWNA 78   Ashbya gossypi...
1723670        8 FLQKLLKTQYDAVFHLKDEn-GIEIYPIFNVLPPkkEYPDYYIIIRNPISLNTLKKRLPh--YTSPQDFVNDFAQIPWNA 84   baker's yeast
XP_721463      8 KLSTKLQSLFNGIYKIEDN--GYLIHPTFQTLPLr-SGTDYYKVVQNPLSLHAVGRKLKnlkYADAQEFINDLALISWNA 84   Candida albica...
XP_457743      9 KLANKLQPLYDGIYSLKDSq-GREISETFQRLPLr-TGTDYYKVIKVPVSLHGVGRYIKkyvYRTAQEFVTQLVQITWNA 86   Debaryomyces h...
XP_503084     25 PISDLISPLFDGIYTIDNDidNNKVFEVFHSLPDr-SLTTYYKVIKRPLSLTQIKRSMPr--YRNVQNFIHDLAQITYNA 101  Yarrowia lipol...
CAG61377       9 ELRTDLRKQYEAIFSLKEEs-GANIFPIFNVLPIkkDYPDYYAIIKNPISLNTLKKRLPh--YTSPQDYVNDVSQIPWNA 85   Candida glabra...
XP_001643343   8 LLYKRLKNEYDELFRVKEEn-NLEIHPIFNVLPSkkEYPDYYALVKNPISFNTLKKRLQg--YNDPQLFVNDVAFIPWNA 84   Vanderwaltozym...
XP_001383373   9 KLNNRLQSLYDRVYKIEDH--GHPIATTFHTLPLr-TGTDYYKIVKNPLSLHGVGRKIKnskYDDGQQFVDDLSQVSWNA 85   Pichia stipiti...
XP_001526784   8 KLLSKLQPIFDSLYNVEEN--GIPIVTHFQTLPLr-TGTDYYKIIKKPLSLHAVGRSIKklkYSNAQEFINDLALISWNA 84   Lodderomyces e...
Feature 1           #     #                   
12230583      93 KTYNTRDSGIYKYALVLEKYLKDTIYPNL 121  baker's yeast
XP_452120     83 RTYNTKDSDVYHYAVILDKCVKDTIIPSL 111  Kluyveromyces lactis NRRL Y-1140
XP_445094     83 KVYNTKESEIYKYALTLEKFINETVYPNL 111  Candida glabrata CBS 138
NP_982942     79 RMYNTKESEIYHYAQIMDRYVREVVIPRI 107  Ashbya gossypii ATCC 10895
1723670       85 MTYNAKDSVIYKYAILLESFIKGKIVHNI 113  baker's yeast
XP_721463     85 RFYNHSKSVIYRQAQILKQYITDVVIPKL 113  Candida albicans SC5314
XP_457743     87 RLYNVRTSLIYDHALILNQYILDKIIPRL 115  Debaryomyces hansenii CBS767
XP_503084    102 RLFNMKGSGIYNDAVFLDGYLNKAIAVLR 130  Yarrowia lipolytica CLIB122
CAG61377      86 KTYNSKGSLIYIYADILEKFLRNVSVPQL 114  Candida glabrata CBS 138
XP_001643343  85 KLYNTPTSVIVKYANILENHIRNSLVPNL 113  Vanderwaltozyma polyspora DSM 70294
XP_001383373  86 RLYNIRESKVYRHALILKQFVLTVVIPKL 114  Pichia stipitis CBS 6054
XP_001526784  85 RYYNLPGSDVYRHAQLLTDFINDYAIVKL 113  Lodderomyces elongisporus NRRL YB-4239

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