Conserved Protein Domain Family
Bromo_polybromo_III

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cd05520: Bromo_polybromo_III 
Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.
Statistics
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PSSM-Id: 99951
View PSSM: cd05520
Aligned: 10 rows
Threshold Bit Score: 155.575
Threshold Setting Gi: 156363502
Created: 13-Sep-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative acetyllysine binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                             #    #  #                                   
AAP34197      382 VSNPFYQLYDTVRSCRNnq------gQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKnqeYETLDHLECDLNLM 455  human
951231        380 TSNPLYQLYDTVRSCRNnq------gQLISEPFFQLPSKKKYPDYYQQIKTPISLQQIRAKLKnheYETLDQLEADLNLM 453  chicken
AAH84946      404 ISSPLYQLYETVRSCRNnr------gQLIAEPFFHLPSKKKYPDYYQQIKNPVSLQQIRSKLKnqeYDGLDQLESDLNLM 477  African clawe...
XP_625055     383 ADNPQWQLFQTIRTAPNnq------gVRMSEYFWKLPSKRLYPDYYKTIKNPISLLQIRTKIKkgeYGTVSEVAGDMNIM 456  honey bee
CAC70156      320 SSEPKWILYWTIRNEPNpvd----peTNLADPFLELPSKSWYPDYFDEISDPMSLFMINKKLKrdeYHTLEELLKDIVLV 395  agent of lymp...
18958139      340 NSEPMWKLYWTIRNAVHekd----rnVTLADNFLELPSKESYPDYYDEIKNPVSIFMINKRLKn-gKYDLKSLVADLMQM 414  Caenorhabditi...
AAF56339      335 GEGPMWALFDHLYNAPGtsehpgvtgPPLGNSLWKLPVRRFHPEYFELIKRPISMSQIHTKLKkgdYANISDLTADLYLM 414  fruit fly
XP_001626082  341 AENPLMMLFNEIYQHTDpt------gRPMVEPFLRLPSRRAYPDYYEVIKKPIALMKIRSQIKsglYDSLEALETELELC 414  starlet sea a...
CAG06951      419 TSNPIFQLYEAVRGARNnq------gQLFSEPFQQLPSRREYPDYYQQIKQPISLQQIRGKMKngeYESLEQIDADLSLM 492  Tetraodon nig...
XP_796375     399 SPDPLHILFNFVLNFRNnl------gQLLSEPFMRLPNSRIYPDYYREIKKPIALTKIRSKLKnnkYKSLEELGTDLELM 472  purple urchin
Feature 1            #   #     #               
AAP34197      456 FENAKRYNVPNsAIYKRVLKLQQVMQAKK 484  human
951231        454 FENAKRYNVPNsAIYKRVLKMQQVMQAKK 482  chicken
AAH84946      478 FENAKRYNVPNsAIYKRVFKLQQLMQAKK 506  African clawed frog
XP_625055     457 FENAKKYNIHTsRLYKCAVKLQKIMQEKV 485  honey bee
CAC70156      396 FENAKTYNVEGsDIYEAAAKLERLARSKT 424  agent of lymphatic filariasis
18958139      415 YSNAFDYNLESsEVYISAEKLKALTISTC 443  Caenorhabditis elegans
AAF56339      415 LDNAKKAFPTShRTHKDALKMLKLMNAKL 443  fruit fly
XP_001626082  415 FNNAKTYNEPNsMLYKDAERMLDHMSKKK 443  starlet sea anemone
CAG06951      493 FENAKRYNMPNsSIYKRAFRLQQIVQSKK 521  Tetraodon nigroviridis
XP_796375     473 FQNAYHYNMPTsQLHKDAEKLHKAMQHKR 501  purple urchin

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