Conserved Protein Domain Family
Bromo_polybromo_II

?
cd05517: Bromo_polybromo_II 
Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.
Statistics
?
PSSM-Id: 99948
View PSSM: cd05517
Aligned: 10 rows
Threshold Bit Score: 144.889
Threshold Setting Gi: 149034194
Created: 13-Sep-2006
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
putative
Feature 1:putative acetyllysine binding site [chemical binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                         #    #  #                                       
AAH78299      184 LKAILEQLLEAIAsctds--sgrlvSELFQKLPsklhYPDYYAVIKEPIDLRAVAQKIQgg-hYKSISAMAKDIDLLVKN 260  zebrafish
951231        179 LKEILEQLLEAVAvatnp--sgrliSELFQKLPskvqYPDYYAIIKEPIDLKTIAQRIQng-tYKSIHAMAKDIDLLAKN 255  chicken
AAP34197      182 LKEILEQLLEAIVvatnp--sgrliSELFQKLPskvqYPDYYAIIKEPIDLKTIAQRIQng-sYKSIHAMAKDIDLLAKN 258  human
AAH84946      234 LKPSLEQLLESITtathp--ggrmiSELFQKLPskvhYPDYYAIIKDPIDLKTIAQRIQsg-hYKSVNAMAKDIDLLTKN 310  African clawe...
AAF56339      191 EYNQYEELFASVMtatdpv-gdrlmHRMFQLLPskkiYPDYYDVIEHPIDLRLIATKIQmn-aYSSLAEMERDLLQMTKN 268  fruit fly
XP_625055     218 TMQQFEDLFAAIMtatdpadnnrplHTMFQLKPskklYPEYYDVIETPVDLKTVARKIQeg-vYNSITDMEKDLMLMCRN 296  honey bee
XP_001626082  143 SQQFYEEMVGAVLemqds--hgriiCELFKRLPpkdlYPEYYAVIKEPIDLKMISTRVRss-yYSTIEDLEKDLQVMVKN 219  starlet sea a...
EDL88964      182 LKEILEQLLEAIVvatnp--sgrliSELFQKLPskvqYPDYYAIIKEPIDLKTIAQRIQdansIKKIFYMKKAEIEHHEM 259  Norway rat
XP_001622014   86 SQQFYEEMVGAVLemqds--hgriiCELFKRLPpkdlYPEYYAVIKEPIDLKMISTRVRss-yYSTIEDWKRIFRYIEGL 162  starlet sea a...
XP_796375     200 PNDPGEILFTAVMghrdv--tgrivSLMFRKLPrqqeFPAYYEIIDNPIDLCDIAIKIKnk-kYDRLSDLDKDLCLMVKN 276  purple urchin
Feature 1         #   #                     #               
AAH78299      261 AKTYNEPGS----------------QVFKDANTIKKVFAQRK 286  zebrafish
951231        256 AKTYNEPGS----------------QVFKDANAIKKIFNMKK 281  chicken
AAP34197      259 AKTYNEPGS----------------QVFKDANSIKKIFYMKK 284  human
AAH84946      311 AKTYNEPGS----------------QVFKDANTIKKLFALKK 336  African clawed frog
AAF56339      269 ACLFNEPGS----------------QIYKDAKSLKRIFTQRR 294  fruit fly
XP_625055     297 ACQFNEPGS----------------QIYKDAKLLKKIITAAA 322  honey bee
XP_001626082  220 AHTFNEPGS----------------QVYKDASAIKKTIQAKK 245  starlet sea anemone
EDL88964      260 TKSSLRISNkravqggrlsaitmalQYGSESEEDAALAAARY 301  Norway rat
XP_001622014  163 RDGNPHMSNw--------------tQSRKPDAATMTPQQLAQ 190  starlet sea anemone
XP_796375     277 AKQFNEPGS----------------QIYKDAVTLKKVMTAKK 302  purple urchin

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap