2YQD


Conserved Protein Domain Family
Bromo_polybromo_V

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cd05515: Bromo_polybromo_V 
Click on image for an interactive view with Cn3D
Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.
Statistics
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PSSM-Id: 99946
View PSSM: cd05515
Aligned: 14 rows
Threshold Bit Score: 168.252
Threshold Setting Gi: 7301208
Created: 13-Sep-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
acetyllysine
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:acetyllysine binding site
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                        #    #  #                                      # 
2YQD_A         16 MQQKLNEVYEAVKNYTDKr-GRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNAC 94   house mouse
CAC70156      681 DKIKLYELYNLIRNYKDEr-GRELSLPFLQLPSKFDYPDYYDVIRRPIDLTKIRNRITSNYYDSTDALISDFNLMFDNAC 759  agent of lymp...
AAF56339      641 ITERLWQFYETVKEYQEPkgKRQLSLIFTKLPSKSEYPDYYDIIREPIDMDRIAQKLKQGAYDTLDDLAADFLLMLENAC 720  fruit fly
XP_625055     664 HLQKLKTMYDTIKDYHDGk-GRQLSLIFMKLPNKNEYPDYYEVIKQPMNMEKIASTLKNNGYENLDELVSDFILMFDNAC 742  honey bee
EAT48776      630 LESKLKHLYDTIREYREPkaNRQLSFIFMKLPSKNEYPDYYDIIKNPIDLERIEFKLRKQNYESVDDMAADFMLMFENAC 709  yellow fever ...
18958139      710 EEQKMWRLFKSMKDVREEgtNRPLAVNFMRLPSKEEFPAYYDVIKKPMDMMRIKHKLENRQYVTLLDVVSDFMLMLSNAC 789  Caenorhabditi...
AAH84946      681 MQHKLNEVYEAVKNYTDKr-GRRLSAIFLRLPSRSELPDYYVTIKRPIDMEKIRSHIMANKYQDLDAMCEDFVTMFNNAC 759  African clawe...
AAH98878       71 LQQKLSELYEAVRNFTDNr-GRRLSTVFLRLPSRSELPDYYAAIKRPIDMERIRGYMVQGRYQDVDSLAEDFILMFNNAC 149  zebrafish
XP_796375     706 LAQKLNELYNAIKNYTDQh-GRELSPPFIRLPSKNEYPEYYQVIKRPMDMQRIQQKIISRGYDQLEDMVNDFLLMFDNAC 784  purple urchin
XP_001626082  617 LKELCRELFNAVKDCTDGs-GRQLCIIFQKLPSRAEYPDYYTLIKKPIDMAKIQSKLNGDQYQTLDDFMADFHLMFDNAC 695  starlet sea a...
Feature 1           #     #                 
2YQD_A         95 TYNEPESLIYKDALVLHKVLLETRRD 120  house mouse
CAC70156      760 RYNEPESMIYKDALSLQKLILLKRRD 785  agent of lymphatic filariasis
AAF56339      721 KYNEPDSQIYKDALVLQQLTLQLKQQ 746  fruit fly
XP_625055     743 KYNEPDSQIYKDALILQRLVLQTKLQ 768  honey bee
EAT48776      710 KYNEPDSQIYKDALCLQQLIIQTKQS 735  yellow fever mosquito
18958139      790 KFNETDSDIYKEAVSLQKALLEMKRE 815  Caenorhabditis elegans
AAH84946      760 TYNEPESLIYKDALVLHKVLLETRRD 785  African clawed frog
AAH98878      150 TYNEPESLIYRDALLLHRAFLEARRR 175  zebrafish
XP_796375     785 KFNEPDSLIYKDALTLQRILLQTKTE 810  purple urchin
XP_001626082  696 KYNEPDSQVYKDSLTLLRSLLRKKAE 721  starlet sea anemone

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