2D9E


Conserved Protein Domain Family
Bromo_brd1_like

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cd05512: Bromo_brd1_like 
Click on image for an interactive view with Cn3D
Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.
Statistics
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PSSM-Id: 99944
View PSSM: cd05512
Aligned: 10 rows
Threshold Bit Score: 186.451
Threshold Setting Gi: 91087827
Created: 12-Sep-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
acetyllysine
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:acetyllysine binding site
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                  #    #  #                                      #   #   
2D9E_A          7 GFLILLRKTLEQLQekDTGNIFSEPVPLseVPDYLDHIKKPMDFFTMKQNLEayrYLNFDDFEEDFNLIVSNCLKYNAKD 86   human
NP_001026635  637 PFLILLRKTLEHLQekDTGNIFSEPVPLseVPDYLDHIKKPMDFQTMKQNLEayrYLNFDDFEEDFNLIINNCLKYNAKD 716  chicken
BAA86600      602 PFNVLLRTTLDLLQekDPAHIFAEPVNLseVPDYLEFISKPMDFSTMRRKLEshlYRTLEEFEEDFNLIVTNCMKYNAKD 681  human
AAH73421      565 PLTVLLRSLLEQLQekDPARIFAHPVNLseVPDYLDHIKHPMDFSTMKKRLEdqrYRNLNEFEEDFNLIIENCMKYNAKD 644  African clawe...
AAF59276      615 PLEAALNKLLDALEarDSMQIFREPVDTseVPDYTDIVKQPMDLGTMRAKLKecqYNSLEQLEADFDLMIQNCLAYNNKD 694  fruit fly
XP_967270     570 PLEASLRLVLDLVAakDTNEIFSEPVDLeeVPDYTTVVSEPMDLSTMRKKLDdglYPDLTSMEKDFDLMIANCLAYNNRD 649  red flour beetle
XP_395348     525 PLESILRSLLEAIKmkDINDVFGQPVNTkeVPDYLEIVSHPMDLSTMQTKIErqeYDTIGAFEADFNLMVNNCLAYNRKD 604  honey bee
XP_001632632  604 PLNIVLRKTLDQVQtkDPGEIFSDPVDTneVLDYLDVIKQPMDFSTMRSRIDsnfYHTIEQFEADFNLIIENCMAYNAQD 683  starlet sea a...
CAI20717      548 PFTVILRAVLDQLQekDQAHIFAEPVNIkeVPDYMDHVLHPMDFSTMSKRIEaqgYKYLDEFEADFNLITDNCMKYNGKD 627  zebrafish
CAF91716      583 PMLVLLRSTLEQLQekDTALIFAQPVDIkeVPDYAEFISQPMDFSTMQSKLEshaYRSVGDLEDDFNLMISNCLLYNTKD 662  Tetraodon nig...
Feature 1           #               
2D9E_A         87 TIFYRAAVRLREQGGAVL 104  human
NP_001026635  717 TIFYRAAVRLREQGGVVL 734  chicken
BAA86600      682 TIFHRAAVRLRDLGGAIL 699  human
AAH73421      645 TIFYRAAVRLRDHGGVLL 662  African clawed frog
AAF59276      695 TVFYRAGIRMRDQAAPLF 712  fruit fly
XP_967270     650 TVFYRAAIKMRDQCGAIF 667  red flour beetle
XP_395348     605 TMFYRAGIKMKEQGGILI 622  honey bee
XP_001632632  684 TIYYRAALKLRDQGRPII 701  starlet sea anemone
CAI20717      628 TFFYRAAVKLRDQGGAIL 645  zebrafish
CAF91716      663 TVYHRTALRLRELGGAVL 680  Tetraodon nigroviridis

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