1E6I,2RI7,1F68,1N72,1JM4,2F6J,2FSA


Conserved Protein Domain Family
Bromo_gcn5_like

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cd05509: Bromo_gcn5_like 
Click on image for an interactive view with Cn3D
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.
Statistics
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PSSM-Id: 99941
View PSSM: cd05509
Aligned: 52 rows
Threshold Bit Score: 138.842
Threshold Setting Gi: 3876449
Created: 12-Sep-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
acetyllysine
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:acetyllysine binding site
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                  #    #  #                                      #   #   
1E6I_A         13 PHDAAIQNILTELQNHaAAWPFLQPVNKEeVPDYYDFIKEPMDLSTMEIKLESNKYQKMEDFIYDARLVFNNCRMYNGEN 92   baker's yeast
2RI7_A         72 KDYEGLKRVLRSLQAHkMAWPFLEPVDPNdAPDYYGVIKEPMDLATMEERVQRRYYEKLTEFVADMTKIFDNCRYYNPSD 151  human
CAG06119     2620 KDYEGLRRTLRSLQAHkMAWPFLEPVDTNdAPDYYRVIKEPMDLSTMEERLQRREYVKLTEFVADMTKIFDNCRYYNPSD 2699 Tetraodon nig...
XP_780572    3352 KDYDHLKKMLRQLQSHkMAWPFLEPVSELdAADYYDVIKDPMDLSTVDDRLKNKHYVKLSDFAADIGKVFDNCRFYNPTD 3431 purple urchin
XP_001636965   51 RDHDSLKRMLRSLQSHkMAWPFLEPVSGLdVPGYYDVIKEPMDLSTVEDKITSKKYATLEQFVSDVTRIFDNCRFFNGKD 130  starlet sea a...
AAN11431     2560 NDVEELKNLIKQMQLHkSAWPFMEPVDPKeAPDYYKVIKEPMDLKRMEIKLESNTYTKLSEFIGDMTKIFDNCRYYNPKE 2639 fruit fly
2F6J_A         72 KDYEGLKRVLRSLQAHkXAWPFLEPVDPNdAPDYYGVIKEPXDLATXEERVQRRYYEKLTEFVADXTKIFDNCRYYNPSD 151  human
2FSA_C         72 KDYEGLKRVLRSLQAHkXAWPFLEPVDPNdAPDYYGVIKEPXDLATXEERVQRRYYEKLTEFVADXTKIFDNCRYYNPSD 151  human
EDP37391     2070 PDFDLLWHAFDSLKSHrTSWPFRQAVDQKnHPDYYSIIKKPMDLSIVQRKLEHYEYHSLKEFTTDIAQIFENARIFNSKD 2149 agent of lymp...
3876449       350 ADYTHVFELLELLLEHrMSTPFRNPVDLNeFPDYEKFIKKPMDLSTITKKVERTEYLYLSQFVNDVNQMFENAKTYNPKG 429  Caenorhabditi...
Feature 1           #                  
1E6I_A         93 TSYYKYANRLEKFFNNKVKEI 113  baker's yeast
2RI7_A        152 SPFYQCAEVLESFFVQKLKGF 172  human
CAG06119     2700 SPFYQCAEVLENFFVQKLKCF 2720 Tetraodon nigroviridis
XP_780572    3432 TPYYQCADVLEKFFIQKMKAL 3452 purple urchin
XP_001636965  131 TPYYRCAEVLEAVFVQKLRAW 151  starlet sea anemone
AAN11431     2640 SSFYKCAEALESYFVQKIKNF 2660 fruit fly
2F6J_A        152 SPFYQCAEVLESFFVQKLKGF 172  human
2FSA_C        152 SPFYQCAEVLESFFVQKLKGF 172  human
EDP37391     2150 SAIYQCADILEKQFRERIVKV 2170 agent of lymphatic filariasis
3876449       430 NAVFKCAETMQEVFDKKLIDV 450  Caenorhabditis elegans

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