Conserved Protein Domain Family
Bromo_RACK7

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cd05508: Bromo_RACK7 
Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular proliferation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.
Statistics
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PSSM-Id: 99940
View PSSM: cd05508
Aligned: 10 rows
Threshold Bit Score: 149.841
Threshold Setting Gi: 23172789
Created: 12-Sep-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative acetyllysine binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                    #     #  #                                      #   #
XP_967933     226 LEHLCNLLKFAVKrmiqcngSEPFIHPVde-kqFPEYRNYIVQPMTLTMLEKNIKdnaYGSTQAFESDAKWILHNSIIFN 304  red flour beetle
AAH97895      191 IEQLSYLLKFALQkmk-qpgTEPFQKPVsl-eqHPDYAEYIFYPMDLSTLEKNVKkkmYGCTEAFLAEAKWILHNCIIYN 268  African clawe...
BAA86439      170 IEQLSYLLKFAIQkmk-qpgTDAFQKPVpl-eqHPDYAEYIFHPMDLCTLEKNAKkkmYGCTEAFLADAKWILHNCIIYN 247  human
AAH58064      151 LEQLSYLLKFALQkmk-qpgTEPFQKPVsl-dqHPNYAEYIFHPMDLSTLEKNIKkkmYGCTEAFLADVKWILHNCIIYN 228  zebrafish
XP_396333     156 VDQLCLLLKHVVErmreypgSEPFWKPVel-seAPNYLDYVVKPMDLSLLESNVRaklYGSTDAFMADAKWIQHNCIVFN 234  honey bee
EAT38185      357 QDSLTISLKFTMKrml-qlkGSAILNPLdk-ehFPNYDAYVTKHIDLTTLQKNVVeqkYQTTDAFQADVNWILHNASIYP 434  yellow fever ...
AAN14280      403 VDLLSQLLSFALDrmkhvrgAHKLRSPLev--fPLTYKKFFVNPVSFESLAQCIRngaYQSTDEFLSEVKWIQHNALILD 480  fruit fly
XP_001625954   99 TDELSKMLKFTLErmk--ekAKDFLQPFcl-ekYDDYLQFVIKPVDLSLLEKNVRkkhYKTAKQFREHAQWILHNAIIYF 175  starlet sea a...
XP_417384     259 TEQLSYLLKFALQkmk-qpgTEPFQKPVsl-dqHPDYAEYIFHPMDLCTLEKNVKkkmYGCTEAFLADAKWILHNCIIYN 336  chicken
XP_791132     158 VDKLAKVLRTSIEkmk-rytNSLLFTPIddlreFRDYRQFVFHPMDLSVMEKNVQsrsYGSTEAFLADAKWIVHNAFVYF 236  purple urchin
Feature 1                    #               
XP_967933     305 Syq------skLTTAAKTIVKICKQEM 325  red flour beetle
AAH97895      269 Ggn------hkLTQTAKVIIKICEHEM 289  African clawed frog
BAA86439      248 Ggn------hkLTQIAKVVIKICEHEM 268  human
AAH58064      229 Ggn------hkLTATAKVIVKICEHEM 249  zebrafish
XP_396333     235 TcggvytdtskLTNAAKQIIKLARQEV 261  honey bee
EAT38185      435 Lns-------kLLSIAKGLMKICKQEI 454  yellow fever mosquito
AAN14280      481 Agd------akVEQASKAVVKVCRQEA 501  fruit fly
XP_001625954  176 Ged------reLTELAEAIMEDCDGEL 196  starlet sea anemone
XP_417384     337 Ggn------hkLTQTAKVIIKICEHEM 357  chicken
XP_791132     237 Gsg------nrYSNAAKALLKACETEM 257  purple urchin

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