Conserved Protein Domain Family
Bromo_brd8_like

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cd05507: Bromo_brd8_like 
Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be a nuclear receptor coactivator. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.
Statistics
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PSSM-Id: 99939
View PSSM: cd05507
Aligned: 14 rows
Threshold Bit Score: 155.215
Threshold Setting Gi: 17534575
Created: 13-Sep-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative acetyllysine binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                 #    #  #                                            
XP_395195  793 YRAWKKAVMLVYNRLatHKYASVFLRPItedqAPGYHSVIFRPMDLSTIKKNIDNGt----------------------I 850  honey bee
CAG32596   782 QKIWKKAIMLVWRAAanHRYANVFLQPVtddiAPGYHSIVQRPMDLSTIKKNIENGl----------------------I 839  chicken
NP_631938 1105 HLLFKKTLLPVWKMIasHRFSSPFLKPVserqAPGYKDVVKRPMDLTSLKRNLSKGr----------------------I 1162 human
AAH57496   633 QKIWKKAIMLVWRAAanHRYASVFLQPVsddiAPGYHSIVHRPMDLSAIKKNIESGq----------------------I 690  zebrafish
AAX27166   272 ARRWRRSLLSALSTVysHRHAYVFMHPVtediAPGYSTVVYEPVDLTSLRRRMESSlsylissqqpsalnpsissyqviV 351  Schistosoma japo...
AAF56879   729 RAASKKLFLSIYAMLldSKHAAPFKRPFhdehAQRHADLCLRPMDFPTIKRNIDSGf----------------------I 786  fruit fly
EAT45132   806 YRAWKKAILSILAKVssCRQAAAFLKPLp---DEQVSDIIYRPMDLSVIKKNVENGi----------------------I 860  yellow fever mos...
NP_495105  642 EDTTKLKLLAMYRYLhdCEWSEAFKKPVpl-gEATYDQGVLERIDLSLIKKEIDNGt----------------------I 698  nematode
CAE59158   681 EAAMKANLMKRWDTIerHPCAEPFREPVpe-cEEEYGLGIHEKVDLSAIRRDIDTGv----------------------V 737  Caenorhabditis b...
AAI23082   584 QKIWKKAIMLVWRAAanHRYANVFLQPVtddiAPGYHSIVHRPMDLSTIKKNIETGl----------------------I 641  western clawed frog
Feature 1                      #   #      #                   
XP_395195  851 RSTMHFQRDVMLMFQNAIMYNKHd-TFIYKMAVSMQEECLQHMQILV 896  honey bee
CAG32596   840 RTTAEFQRDIMLMFQNAVMYNSSd-HDVYHMAVEMQRDVLEQIQQFL 885  chicken
NP_631938 1163 RTMAQFLRDLMLMFQNAVMYNDSd-HHVYHMAVEMRREVLEQIQVLN 1208 human
AAH57496   691 RTTAEFQRDIMLMFQNAVMYNSSd-HDVYHMALEMQRDVLEQIQQFL 736  zebrafish
AAX27166   352 EVAARFIRDLLLMFMNARMYNSQn-HEVHRMAGEMYHDVISELQPLW 397  Schistosoma japonicum
AAF56879   787 RSLSELHRDVLLMAHNVLVAYKPhtAQHKTARLFVQDCQAIKEFSQL 833  fruit fly
EAT45132   861 RSSSEFQRDVMLMYTNAMVLNRPd-LCCSKAANFLVTECIALMESIP 906  yellow fever mosquito
NP_495105  699 NSESGFLLRAYRMLSNAIMYNGYd-HDVHLHAKYIIEHVMNDIHTLN 744  nematode
CAE59158   738 DGLTLFLLRTYRMFSNAVMFNGYd-HDVALQAKDIHCSTMKLMVQEI 783  Caenorhabditis briggsae
AAI23082   642 RSTAEFQRDIMLMFQNAVMYNSSd-HDVYHMAVEMQRDVLEQIQQFL 687  western clawed frog

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