2E7O


Conserved Protein Domain Family
Bromo_BAZ2A_B_like

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cd05503: Bromo_BAZ2A_B_like 
Click on image for an interactive view with Cn3D
Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting protein 5) and hWALp3. The proteins may play roles in transcriptional regulation. Human Tip5 is part of a complex termed NoRC (nucleolar remodeling complex), which induces nucleosome sliding and may play a role in the regulation of the rDNA locus. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.
Statistics
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PSSM-Id: 99935
View PSSM: cd05503
Aligned: 13 rows
Threshold Bit Score: 180.263
Threshold Setting Gi: 115698917
Created: 13-Sep-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
acetyllysine
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:acetyllysine binding site
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                 #    #  #                                               
2E7O_A         11 DLALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKVIKKPMDFSTIREKLSsg---------qYPNLETFALDVRLVFDN 81   human
AAN61105     1590 DLTFCEIILMELESHEDAWPFLEPVNPRLVPGYRKIIKNPMDFSTMRHKLLng---------nYSRCEEFAEDAELIFSN 1660 African clawe...
CAG04063     1351 DLTFCEIILMEMEAHADAWPFLEPVNPRLVPGYRRIIKNPMDFPHHEGAAAagrvsppsdrpaYNSCEEFAADAQLVFNN 1430 Tetraodon nig...
NP_990008    2027 DLAICSMILSELETHEDAWPFLLPVNLKLVPGYKKVIKKPMDFSTIRDKLTsg---------qYPNVEAFSLDVRLVFDN 2097 chicken
30794571     1264 NKELCQLMLDELVVQANALPFLEPVNPKLVPGYKMIISKPMDLKTIRQKNEkl---------iYETPEDFAEDIELMFAN 1334 Caenorhabditi...
AAM68712      579 ELAVCKTLLGEMELHEDSWPFLLPVNTKQFPTYRKIIKTPMDLSTIKKKLQdl---------sYKTREDFCVDVRQIFDN 649  fruit fly
Q9UIF9       1771 DLTFCEIILMEMESHDAAWPFLEPVNPRLVSGYRRIIKNPMDFSTMRERLLrg---------gYTSSEEFAADALLVFDN 1841 human
XP_001636877  214 DMAPCRTILAEMEKHDDAWPFLIPVNAKQFPEYYKIIRKPMDFHTMKIKLRdy---------qYSSPQEFAQDSRLVFAN 284  starlet sea a...
NP_725061     356 ELAVCKTLLGEMELHEDSWPFLLPVNTKQFPTYRKIIKTPMDLSTIKKKLQdl---------sYKTREDFCVDVRQIFDN 426  fruit fly
Q9UIF8       1869 DLALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKVIKKPMDFSTIREKLSsg---------qYPNLETFALDVRLVFDN 1939 human
NP_001092209  341 DLGLCRILLAELERHQDAWPFLNPVNLKSVPGYRKVIKKPMDFSTIREKLVss---------qYQNLETFIIDVNLVFDN 411  zebrafish
XP_783177    2141 ELQPCKQILGEIEKEQNSWPFMAPVNTKQIPTYRKIIKQPMDFSTMKSKLKek---------kYKTLDEFAGDARLIFDN 2211 purple urchin
EDP30475     1462 MKNLFNTMLDELWARPESGPFQYPVDTKEVPFYKKVIKRPMDLNQIRMNVEnn---------kYMTQESFIEDLEQIFEN 1532 agent of lymp...
Feature 1         #   #     #               
2E7O_A         82 CETFNEDDSDIGRAGHNMRKYFEKKW 107  human
AAN61105     1661 CQLFNEDESDVGKAGLILKKFYDARW 1686 African clawed frog
CAG04063     1431 CELFNEDTSEVGVAGHAMRRFFESRW 1456 Tetraodon nigroviridis
NP_990008    2098 CETFNEDDSDIGRAGHNMRKYFEKKW 2123 chicken
30794571     1335 CRQFNIDHSEIGRAGISLHKFFQKRW 1360 Caenorhabditis elegans
AAM68712      650 CEMFNEDDSPVGKAGHGMRKFFESRW 675  fruit fly
Q9UIF9       1842 CQTFNEDDSEVGKAGHIMRRFFESRW 1867 human
XP_001636877  285 CEEFNEDDSEVGQAGKRLSKFFESRW 310  starlet sea anemone
NP_725061     427 CEMFNEDDSPVGKAGHGMRKFFESRW 452  fruit fly
Q9UIF8       1940 CETFNEDDSDIGRAGHNMRKYFEKKW 1965 human
NP_001092209  412 CEKFNEDNSDIGRAGHNMRKFFEKRW 437  zebrafish
XP_783177    2212 CETFNEDESEVGRAGHAMRSFFETRW 2237 purple urchin
EDP30475     1533 CRTFNEDESPIGQSGVTLHKFYLKRW 1558 agent of lymphatic filariasis

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