Conserved Protein Domain Family
Bromo_tif1_like

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cd05502: Bromo_tif1_like 
Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or corepressors to modulate transcription. Vertebrate Tif1-gamma, also labeled E3 ubiquitin-protein ligase TRIM33, plays a role in the control of hematopoiesis. Its homologue in Xenopus laevis, Ectodermin, has been shown to function in germ-layer specification and control of cell growth during embryogenesis. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.
Statistics
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PSSM-Id: 99934
View PSSM: cd05502
Aligned: 20 rows
Threshold Bit Score: 153.986
Threshold Setting Gi: 83405105
Created: 13-Sep-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative acetyllysine binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                      #   #  #                                         # 
XP_420989    1119 LDDYDQKKCEKLVLSLFCS-SMSLPFHEPVSpLARHYYQIIKRPMDLSIIRKKLQkkdkfHYSAPEELVTDVRLMFWNCA 1197 chicken
CAI11773      264 LSACDQRKCEKLTLLILSN-ILSAPFHEPVSpLARHYYQIIKKPMDLSVIRNRLGsnshtHYCSPQEFVADVLLMFKNCA 342  zebrafish
CAG05611       73 LSNQEQRRCEKLALRLYSH-ALSAPFHEPVSpLAQNYYQIIRRPIDLSLIRRRLDetntlHYFSVEQFIDDVLLMFKNCA 151  Tetraodon nig...
XP_001639744   72 QTFISLQICEKILLELFCH-SDSIPFQQKVSkSVPNYYKVITHPMDLSTIRAKIQpqhfqHYSSITEFLSDCQLIFSNCA 150  starlet sea a...
BAE93320     1000 LQGKPLKLCERILLELFCH-SKSSPFHFPVKnSVPNYYKLIKEPMDFLKIKKKLQpgnfqHYAGCEKFLSDVYLVFTNCY 1078 Ciona intesti...
XP_001605295  945 MSTRDLRIAQRIVLELYCQyEQSLPFREVVPpEIVEYHRVIKKPIALDVIKEKLKpesenHYTDLKQVIADIRLMFKNAY 1024 jewel wasp
AAF19646      963 LSALELRILQRICLELYCQyEQSLNFREPESpANTSYYEIVSSPMSLDVIRTRLDpsspnHYKDIAGFVSDVRLIFSNTY 1042 fruit fly
XP_972064     668 LCYKDKKIAERIVLELYCQyDPSLPFREVIGpENEEYHAIIKTPIALDSIRQKLNwnspeHYTTMEQLIKDVRLMFKNAY 747  red flour beetle
EAT40732      872 ITPLELKILQRIILELFCQyETSMPFRHLEPeINKAYYDIVCNPISLTMIRDKLEmtnpgHYTDIASFVADIRRLFSNVY 951  yellow fever ...
XP_785438    1184 FTAREFKLCQRLLLEMYCL-EDSQPFLEPVGpEVTGYLEIIPIPMDLSTIKSKLSltspnKYFSPRQMVEDLRVMFTNCY 1262 purple urchin
Feature 1           #     #                     
XP_420989    1198 KFNYpdseVAEAGRCLDVFFEGKLKEIYPD 1227 chicken
CAI11773      343 KFNYpdseVAQAGHSLQSFFISKLREVFPD 372  zebrafish
CAG05611      152 TFNYpdseVAQAGQNLETFFLNQLKEVFPE 181  Tetraodon nigroviridis
XP_001639744  151 TFNDesseVGRMGNNLELYYMSLLQKFLPE 180  starlet sea anemone
BAE93320     1079 LFNGedtsLGRAAKEVQKYFYERVQLWLPF 1108 Ciona intestinalis
XP_001605295 1025 TFNPpesqVFHEAKSLDYFFEKLLTKWAEN 1054 jewel wasp
AAF19646     1043 LFYQedtkTYSNAKYLENFFEEQLAKWLPQ 1072 fruit fly
XP_972064     748 TYNPedsqVYADAKVLEKFFDEQLEKFLPE 777  red flour beetle
EAT40732      952 LFYQedsiTFKNAHKLEKFFEQQLAKWLPK 981  yellow fever mosquito
XP_785438    1263 QYNGetsdLGKIAQHLQRYASRFMKRYLPE 1292 purple urchin

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