Conserved Protein Domain Family
Bromo_SP100C_like

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cd05501: Bromo_SP100C_like 
Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin level. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.
Statistics
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PSSM-Id: 99933
View PSSM: cd05501
Aligned: 6 rows
Threshold Bit Score: 157.975
Threshold Setting Gi: 110760414
Created: 13-Sep-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative acetyllysine binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                            #           #  #                             
6166538       757 PEEQLKCEFLLLKVYCC---------SESSFFAKIPyy-------yyIREACQGLKEPMWLDKIKKRLNEhGYPQVEGFV 820  human
AAK51202      773 PEEQLKCEFLLLKVYCD---------SKSCFFASEPy---------yNREGSQGPQKPMWLNKVKTSLNEqTYTRVEGFV 834  human
BAC38855      474 QTRRQKCELLLLTIYCY---------PKSGFFIPKPk---------qRKEKFPDLREHMWLNKIKNRLNKkAYHSVRRFV 535  house mouse
Q9HB58        568 KRMLWSCTFCRMKRSSG---------SQQCHHVSKTlerqmqpqdqlIRDYGEPFQEAMWLDLVKERLIT-EMYTVAWFV 637  human
XP_001513758  997 PEELLKCEFLLLKIFCL---------YDSKIFIEDPe---------rIKDYYQHIKEPMWLNLIKERLHQgMYNTIEGFV 1058 platypus
XP_397364    1473 PLALSKLEMIHQTVWQMdeaevfkcpSSGGNNQSSTy---------tIEDYCKVIKSPMFLETVEYKLKNrVYHKVEHVV 1543 honey bee
Feature 1                  #   #     #                     
6166538       821 QDMRLIFQNHRASYKyk-gFGQMGFRLEAEFEKNFKEVFAI 860  human
AAK51202      835 QDMRLIFHNHKEFYRed-kFTRLGIQVQDIFEKNFRNIFAI 874  human
BAC38855      536 EDMRLIFHNHSIFYKk--rFKNLGIIVGKKFEKNFKRIFSI 574  house mouse
Q9HB58        638 RDMRLMFRNHKTFYKas-dFGQVGLDLEAEFEKDLKDVLGF 677  human
XP_001513758 1059 LDMRLIFKNCWKFNKnn-kFGQMGIKLKKVFEKNFKQVFSI 1098 platypus
XP_397364    1544 RDFRRIVYNSKLYHKddhdRVKVIETLSKKLEELFEEHFAS 1584 honey bee

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