Conserved Protein Domain Family
Bromo_BDF1_2_I

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cd05500: Bromo_BDF1_2_I 
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.
Statistics
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PSSM-Id: 99932
View PSSM: cd05500
Aligned: 14 rows
Threshold Bit Score: 157.09
Threshold Setting Gi: 71018707
Created: 13-Sep-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative acetyllysine binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                      #      #  #                                        
5921175       149 IPKHQQKHALLAIKAVK-RLKDARPFLQPVDPvkLDIPFYFNYIKRPMDLSTIERKLNvg-------------------- 207  baker's yeast
XP_759584     105 ISAAQLKFAQSTLKSLK-TRREAIAFLAPVDPvaLGIPQYPQIITKPMDFGTIDIKLAltalvlkpnskpgdkaksapqw 183  Ustilago mayd...
XP_504191     121 MPKHQVKYAASSLKAVK-RLKDAAPFIHPVDPvkLNIPTYFEVIKHPMDLGTMEKKLNng-------------------- 179  Yarrowia lipo...
AAW46194      717 LTLTQHKYMLNAVRSLKkRLPDAYNFLVPVDTvrFNIPHYHTVIDTPMDLGTVETKLIvsdprgppkdks-------kms 789  Cryptococcus ...
EAS36106      253 ITPLQNKFFIRTLAALK-RTHDARFFRVPVDPvkLNIPNYPTIIKEPMDLHTMEDKIKsg-------------------- 311  Coccidioides ...
1431082       134 LPPHQSKYLLSSIKATK-RLKDARPFLKPVDPiaLNIPHYFNYVQTPMDLSLIETKLQgn-------------------- 192  baker's yeast
XP_001544643   74 LTAKQSKFLVRCIQGLK-RVHDSRFFREPVDPvkLNIPNYPLIIKQPMDLRTIEEKLKag-------------------- 132  Ajellomyces c...
EAU93307      826 MSLAQWKYCGSCIRSLK-KLKDSIPFLKPVDPvqLNIPHYPSIIKHPMDFSTIERKLNssnpvkpd-------------- 890  Coprinopsis c...
XP_001486510   93 IPKHQAKFALNSIKTIK-RLRDAAPFTVPVDTvkLNIPLYYNYIKRPMDLSTIERKINln-------------------- 151  Pichia guilli...
NP_588301      85 MPPPQQKYCLAIVRQLK-RTKNSAPFKVPVDPikQNIPDYPTIVKNPMDLGTIEKKLTsy-------------------- 143  Schizosacchar...
Feature 1                                  #   #     #               
5921175       208 -------aYEVPEQITEDFNLMVNNSIKFNGpnagISQMARNIQASFEKHM 251  baker's yeast
XP_759584     184 gldpakdvYRRMHDFEADVRQVFFNCATFNGpdspYTHNARVLEAAFDKYM 234  Ustilago maydis 521
XP_504191     180 -------eYGTKEDMIADVQRIVDNCLTFNGadsfISSMAKSLFTSFERHM 223  Yarrowia lipolytica CLIB122
AAW46194      790 kwdtskgkYNNVAEVTEDVRRIWENSRKFNGkehpVSQMATRLEEAFERSL 840  Cryptococcus neoformans var. neoformans JEC21
EAS36106      312 -------aYKTVDQITADFKLMIDNCITFNGpehvVTVEGMRLRDNWERHL 355  Coccidioides immitis RS
1431082       193 -------vYHSVEQVTSDFKTMVDNCLNFNGpessISSMAKRIQKYFEKKL 236  baker's yeast
XP_001544643  133 -------sYTSLFAVTSDFDLMVDNSVTFNGpehvVSMEGANLKQSFERHL 176  Ajellomyces capsulatus NAm1
EAU93307      891 -pnpdnprYLTVEDFVSDVRLVFTNCLTFNGpdhvVTQMGKRVEQVFDKHL 940  Coprinopsis cinerea okayama7#130
XP_001486510  152 -------aYADVSEIVDDFTLMVDNCCRFNGrrlpLYHKWLRISRAISKSI 195  Pichia guilliermondii ATCC 6260
NP_588301     144 -------eYSVPQEFIDDMNLMFSNCFLYNGtespVGSMGKALQEVFERQL 187  Schizosaccharomyces pombe 972h-

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