Conserved Protein Domain Family
Bromo_BDF1_2_II

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cd05499: Bromo_BDF1_2_II 
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.
Statistics
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PSSM-Id: 99931
View PSSM: cd05499
Aligned: 13 rows
Threshold Bit Score: 161.684
Threshold Setting Gi: 19173489
Created: 18-Sep-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative acetyllysine binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                    #      #  #                                      #   
NP_013503     317 AMKFCQSVLKELMAKkhasYNYPFLEPVDpvsmnLPTYFDYVKEPMDLGTIAKKLNdwqYQTMEDFERDVRLVFKNCYTF 396  baker's yeast
P35817        317 AMKFCQSVLKELMAKkhasYNYPFLEPVDpvsmnLPTYFDYVKEPMDLGTIAKKLNdwqYQTMEDFERDVRLVFKNCYTF 396  baker's yeast
CAG85306      313 ELRFCNQTVKELISKkhynYNFPFLAPVDtvalnIPNYAEVVKEPMDLGTIQTKLAnnqYENGDEFERDVRLVFKNCYAF 392  Debaryomyces ...
EAT76963      544 ELKFCESVLAELLKPkyaaVSYPFVSPVDpvalnIPSYLKIIKKPMDFGTIEKNLKagmYQSAKDFHADAHLVFQNCYKF 623  Phaeosphaeria...
XP_001550210  549 ELKWCEETLNELKKPkylaFSGAFMDPVDpvalqIPNYFTVIKSPMDISTVSEKLQngaYTRAKEFEQDVKLIFHNCYKF 628  Botryotinia f...
EAS36106      455 ELKFCEEVIDELHKPkhynFAAPFYQPVDpvalnIPTYHNIIKKPMDLSTIRTKLQtgqYENSKEMENDVRLMFKNCYKF 534  Coccidioides ...
XP_364080     573 DLKYCDDILKDLAKPkshgIAWIFAKPVDetrdgAPGYYSIIKKPMDLGTMTVKLQegkYRSAADFKADFDLMLNNCFTF 652  Magnaporthe g...
NP_597292     153 DYEFCSETLSDLVKPkhkaYNWPFLEPVDgd--lVPGYYSVIKEPMDLQTMRSKLEqrrYQSVEEFGRDLELIVENCKKF 230  Encephalitozo...
XP_759584     332 ELRFCTRVIDDLLKPtfsnVAWVFYDQPTmdfdwAPAYFQMIKKPIALRDVQKNIRsgeYADAQEFDTDMQLLFQNCFTF 411  Ustilago mayd...
XP_963183     636 ELRFCEEVLTELRKQryyeFNEAFQKPVDpvalnIPTYHKIIKKPMDLSTMQSKLNagdYASAKEFERDFDLIIKNCRLF 715  Neurospora cr...
XP_384599     523 ELQFSEEVLSDIMHPkntaLNSWFMDPVDaeglnIPHYYSIIKKPMDLNKVSRMLKngeITSIKDFDKNVRLIFTNCYTF 602  Gibberella ze...
Q07442        322 KFRTCLKILKVLMSKknsdINFPFLQPVDpialnLPNYFDVVKNPMDLGTISNNLMnwkYKTIDQFVDDLNLVFYNCFQF 401  baker's yeast
NP_010213     322 KFRTCLKILKVLMSKknsdINFPFLQPVDpialnLPNYFDVVKNPMDLGTISNNLMnwkYKTIDQFVDDLNLVFYNCFQF 401  baker's yeast
Feature 1         #        #               
NP_013503     397 NPDGt---iVNMMGHRLEEVFNSKW 418  baker's yeast
P35817        397 NPDGt---iVNMMGHRLEEVFNSKW 418  baker's yeast
CAG85306      393 NPEGt---dVNMMGHRLESIFDKKW 414  Debaryomyces hansenii CBS767
EAT76963      624 NPEGd---aVNKMGHDLEDIFEKLW 645  Phaeosphaeria nodorum SN15
XP_001550210  629 NPEGn---pVRLMGRQFEDVFNGLL 650  Botryotinia fuckeliana B05.10
EAS36106      535 NIPGd---pTYNAGKKLEEIFDYKW 556  Coccidioides immitis RS
XP_364080     653 NPAGt---dVHALARNLEAYFQDKW 674  Magnaporthe grisea 70-15
NP_597292     231 NAPGt---eVYVCGQEFEKAVKMHM 252  Encephalitozoon cuniculi GB-M1
XP_759584     412 NPPGs---dVYTMGEQLKSVYEDKM 433  Ustilago maydis 521
XP_963183     716 NGEQh---iVYEQALRLQSLYRREM 737  Neurospora crassa OR74A
XP_384599     603 NGSVdqgnaVSYVASQLEGYYNGLM 627  Gibberella zeae PH-1
Q07442        402 NPEGn---eVHSMGKKLKELFNFHW 423  baker's yeast
NP_010213     402 NPEGn---eVHSMGKKLKELFNFHW 423  baker's yeast

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