2OO1,2DVV,2DWW,2G4A,2I8N,2OUO,2E7N


Conserved Protein Domain Family
Bromo_Brdt_II_like

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cd05498: Bromo_Brdt_II_like 
Click on image for an interactive view with Cn3D
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.
Statistics
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PSSM-Id: 99930
View PSSM: cd05498
Aligned: 27 rows
Threshold Bit Score: 164.759
Threshold Setting Gi: 85105579
Created: 17-Sep-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
acetyllysine
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:acetyllysine binding site
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                 #      #  #                                      #   
2OO1_A       8 HLRYCDSILREMLskkhaayAWPFYKPVdaealeLHDYHDIIKHPMDLSTVKRKMDgreYPDAQGFAADVRLMFSNCYKY 87   human
AAK39326   262 SMKPCLKLLNDFStkkyqefAWPFNEPVdaeqlgLHDYHKIIKEPMDLKSMKAKMEsgaYKEPSDFEHDVRLMLRNCFLY 341  nematode
22265870   556 WQKFCSKLLNEIHsvknkgfAQVFYLPVdpiklkIYDYLEVITNPMDLQTIKKKLDfkqYAEPEEFVHDINLMVDNCCKY 635  Caenorhabditis e...
EAL24961     2 ESNACKAIIRKLFssqykklAWIFYEPIdapylgLHDYHKIVKKPMDLNSIRTRLQaglYVNADEFVRDVRLMFDNTYLY 81   Drosophila pseud...
EDP34844   217 QMKFCQRLVNELFtkkcksfTWPFLEPVdveglkLEDYYDIVKNPMDLGTIRRKLDakqYATPEELRADVILICENCYKY 296  agent of lymphat...
CAB40169   256 QMRFCSTVLKELYkrqyesfAFPFYQPVdpvacdCPDYFDVIKEPMDLSTIQSKLNkneYSTLEEFESDILLMFNNCFTY 335  fission yeast
CAC05484   393 EMKFCQSVLKELLkkqheayAYPFYKPVnptacgCPDYFKVIKHPMDLGTMQNKLNhneYASMKAFEADMVLMFKNCYKF 472  fission yeast
CAD26468    16 QLKYCSQILTRLKrn---snAPPFLEPVdpvklgIPDYPEKIKHPMDLSTIRKKLDskeYEGPEGFDGDMRLMFSNCYTY 92   Encephalitozoon ...
EAU93307  1032 QFKFCSKLLNDLFkkqyyniAHPFYEPVdwvrmeIPSYPKIIKKPMDMSTMRKKLDngeYATPQKFAEDFRLMLRNCSTF 1111 Coprinopsis cine...
NP_588301  256 QMRFCSTVLKELYkrqyesfAFPFYQPVdpvacdCPDYFDVIKEPMDLSTIQSKLNkneYSTLEEFESDILLMFNNCFTY 335  Schizosaccharomy...
Feature 1      #     #               
2OO1_A      88 NPpdheVVAMARKLQDVFEMRF 109  human
AAK39326   342 NPvgdpVHSFGLRFQEVFDRRW 363  nematode
22265870   636 NPkgspAHSNALELRSFFEQRW 657  Caenorhabditis elegans
EAL24961    82 TTpdhlCHQMAKKLQAIFEAMF 103  Drosophila pseudoobscura
EDP34844   297 NPtsdpIHQHGRALQKYFEDKW 318  agent of lymphatic filariasis
CAB40169   336 NPpgtpVHVMGRQLENVFKEKW 357  fission yeast
CAC05484   473 NSagtpVHLMGKKLESIFQKLW 494  fission yeast
CAD26468    93 NPpgtvVHEMGKGLEAVYTDLM 114  Encephalitozoon cuniculi GB-M1
EAU93307  1112 NPvgtpVCTAGQQLGRVFEEKW 1133 Coprinopsis cinerea okayama7#130
NP_588301  336 NPpgtpVHVMGRQLENVFKEKW 357  Schizosaccharomyces pombe 972h-

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