Conserved Protein Domain Family
Bromo_ALL-1

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cd05493: Bromo_ALL-1 
Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
Statistics
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PSSM-Id: 99925
View PSSM: cd05493
Aligned: 9 rows
Threshold Bit Score: 134.485
Threshold Setting Gi: 115968092
Created: 14-Sep-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative acetyllysine binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                              #             #  #         
Q03164       1647 VLTALLNSRTTSHLLRYrq----------aaKPPDLNPETEESIPSRSSPEGPDpp---------vlTEVSKQDDQQPLD 1707 human
XP_417896    1822 VLTALLNSRTTSHLLRYrq----------aaKPPDLNPETEESIPSRSSPEGPDpp---------vlTEVSKQEEQQPLD 1882 chicken
XP_417896    1532 CDKCYDDDDYESKMMQCg-------------KCDRWVHSKCENLSGFNSPVEFEny----------qPPAALQTGIPNLS 1588 chicken
XP_001190252 2083 EAETVSESETKVSIVSPeavpd-----vdpnIPDAVLEVTTSTQPEQDASKTPAkvvtie--igkkeEEEKKEEEIKPTS 2155 purple urchin
O08550       1380 EDYEILSGLPDSVLYTCg------------pCAGATQPRWREALSGALQGGLRQvlq-------gllSSKVAGPLLLCTQ 1440 house mouse
XP_695205      37 GWRELLDQELRTGLERL--------------LSCMMGSTVTQHLVTCKKCSTLG-------------SSNIGVEELPICD 89   zebrafish
CAK03604      225 LHEILCRLRGKSLVFSCapcsksfcsgwqdvVQEVLRNGLEKIMGGLKNSLNIShlrlca--qceacPDFEVVKGRSGCC 302  zebrafish
XP_001622959  157 CLSDLPDSIPFVCKLCCq------------eENPKWLQEMQEEMQAGYQRVIDEvessrgyqpligyFSQVEFENGTPKD 224  starlet sea a...
NP_001103749 1841 VLTALFNSRTSTHLLRYrqa---------vmKPPELNPETEESLPSRRSPEGPDpp----------vLTEVSPPNDSPLD 1901 zebrafish
Feature 1                                                #   #                         #          
Q03164       1708 LEGVKRKMDQG----------NYTSVLEFSDDIVKIIQAAINSDGGQPEIKKA--------NSMVKSFFIRQMERVFPWF 1769 human
XP_417896    1883 MEGVKRKMDQG----------GYVSVLDFSDDIVKIIQAAINSDGGQPEIKKA--------NSMVKSFFIRQMERVFPWF 1944 chicken
XP_417896    1589 LFRVNEDLYAYecare-yivgSILTSLDFSDDIVKIIQAAINSDGGQPEIKKA--------NSMVKSFFIRVVPENGFEV 1659 chicken
XP_001190252 2156 FQFVKAKMMAG----------YYKSVEKFTKDCVTIFQASFNQETSLIPGLSKs-------NVIAKGAFFKIMIQMFPWF 2218 purple urchin
O08550       1441 CGQDGKQLHPGpcdlqavgkrFEEGLYKSVHSFMEDVVAILMRHSEEGETPERr------aGSQMKGLLLKLLESAFCWF 1514 house mouse
XP_695205      90 LSAIGKKFEGG----------HYTSLKSFHEDVVKVLRRYLEEEEVLPEDQKH--------TALARSYYLTLLEDVYGWF 151  zebrafish
CAK03604      303 LHPVEKKLENG----------LYTSLKSFHEDVVKVMVERLRREEYLLEAQRP--------TSQAKLYYIKLVEQVFSWF 364  zebrafish
XP_001622959  225 LDAVRAKVKEN----------AYRVVGDFCHDMLLILNKVCKITGNQPLVRNAavlyevfiKEVGAMFPWHKIKSVQDST 294  starlet sea a...
NP_001103749 1902 LESVEKKMDSG----------CYKSVLEFSDDIVKIIQTAFNSDGGQLESRKA--------NSMLKSFFIRQMERIFPWY 1963 zebrafish
Feature 1                 
Q03164       1770 SVKKSRFW 1777 human
XP_417896    1945 SVKKSRFW 1952 chicken
XP_417896    1660 LRRVFVDF 1667 chicken
XP_001190252 2219 NIEDTRLW 2226 purple urchin
O08550       1515 DAHDPKYW 1522 house mouse
XP_695205     152 NSQDPKLW 159  zebrafish
CAK03604      365 NSQDPKTW 372  zebrafish
XP_001622959  295 TTETVKPE 302  starlet sea anemone
NP_001103749 1964 KVKESKFW 1971 zebrafish

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