Conserved Protein Domain Family
Bromo_ZMYND11

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cd05492: Bromo_ZMYND11 
Bromodomain; ZMYND11_like sub-family. ZMYND11 or BS69 is a ubiquitously expressed nuclear protein that has been shown to associate with chromatin. It interacts with chromatin remodeling factors and might play a role in chromatin remodeling and gene expression. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.
Statistics
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PSSM-Id: 99924
View PSSM: cd05492
Aligned: 10 rows
Threshold Bit Score: 144.831
Threshold Setting Gi: 114629039
Created: 13-Sep-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative acetyllysine binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                            #                   #  #                    
XP_700244    264 MTTYLKFILGRMKe--------------RAVNLHKRGQea---------------kQPIYQRLIHTLLDVENIQENISDg 314 zebrafish
AAH12586     118 MGTYLRFIVSRMKe--------------RAIDLNKKGKdn---------------kHPMYRRLVHSAVDVPTIQEKVNEg 168 human
XP_418557    158 MSTYLRFIVSRMKe--------------RAIDLNKKGKdn---------------kHPMYRRLVHSAVDVPTIQEKVNEg 208 chicken
EAL25508     234 LSCLLQYSWSKHQswlrt------dvdiDMKSLSSRDRa-----------------LVKRVLFKSNTLGQADIQKNIESk 290 Drosophila pseu...
AAF58494     243 LGCLLKYSWDQHHswism-----dvakyMAKHWNERDKa-----------------LVKRLLFKTKILGLGDIERNIAAa 300 fruit fly
NP_001096471 158 MGKYMRFIVSRMKe--------------RAIELNKKGKds---------------kHPMYRRLVHTTIDVSTINEKVTEg 208 western clawed ...
XP_312072    170 LNYLLKFVVEQYKswflr------dtarQTPVVTRKTI------------------DICRKMLLRIPTSFADVREKITSe 225 Anopheles gambi...
XP_393096    143 LNHILSFTCGHLKaklpp------eitnRTIVFNNDPIvtpanrysgttwisegedAWRPGVLIKHHMDLAIMDTKIKKn 216 honey bee
XP_968747    217 LNYLLKFVIHRIQswlp-------htltHTMAQQERPEwltd-----------kelSWRANQLFFEHRDMSVIEVNLNNe 278 red flour beetle
XP_001136035 113 LICDLCFRVYHSKclsdefrlrdssspwQCPVCRSIKKk----------------nTNKQEMGTYLRFIVSRMKERKVNe 176 chimpanzee
Feature 1                           #   #     #                     
XP_700244    315 -KYKSFEEFKADAQLIVHNTAILHGVnSDQTEIARLLYNDTCHELNELMLC 364 zebrafish
AAH12586     169 -KYRSYEEFKADAQLLLHNTVIFYGAdSEQADIARMLYKDTCHELDELQLC 218 human
XP_418557    209 -KYRSYEEFKADAQLLLHNTVIFYGAdSEQADIARMLYKDTCHELDELQLC 258 chicken
EAL25508     291 -KYTYLTEFFVDLLDLQHNIGVFFGHtEQPYNATQWLMRDVTHDIREIRRC 340 Drosophila pseudoobscura
AAF58494     301 -KYTYLTEFLMDLLDLQHNMAVFFGQkSVEYNATKWLMRDVTHDIREIRRC 350 fruit fly
NP_001096471 209 -KYKSYDEFKADAQLLLHNTIIFYGDdSEQADVAKVLYKDTCHELDELQLC 258 western clawed frog
XP_312072    226 -QYARLEEFHVDLLDIVHNVAIIHGDtSTAYSAAMYFLADCVYDLREIRHC 275 Anopheles gambiae str. PEST
XP_393096    217 -EYNNLAEFQADAHNILHNIIIYHGThSIIGEMGHTMYQDCCYDLQEIRRC 266 honey bee
XP_968747    279 -SYTKLYQFLADVLTIQHNVAIFHGIeSQEYGAAELMIRDCMHDLTELKLC 328 red flour beetle
XP_001136035 177 gKYRSYEEFKADAQLLLHNTVIFYGAdSEQADIARMLYKDTCHELDELQLC 227 chimpanzee

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