1T6G


Conserved Protein Domain Family
xylanase_inhibitor_I_like

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cd05489: xylanase_inhibitor_I_like 
Click on image for an interactive view with Cn3D
TAXI-I inhibits degradation of xylan in the cell wall.
Xylanase inhibitor-I (TAXI-I) is a member of potent TAXI-type inhibitors of fungal and bacterial family 11 xylanases. Plants developed a diverse battery of defense mechanisms in response to continual challenges by a broad spectrum of pathogenic microorganisms. Their defense arsenal includes inhibitors of cell wall-degrading enzymes, which hinder a possible invasion and colonization by antagonists. Xylanases of fungal and bacterial pathogens are the key enzymes in the degradation of xylan in the cell wall. Plants secrete proteins that inhibit these degradation glycosidases, including xylanase. Surprisingly, TAXI-I displays structural homology with the pepsin-like family of aspartic proteases but is proteolytically nonfunctional, because one or more residues of the essential catalytic triad are absent. The structure of the TAXI-inhibitor, Aspergillus niger xylanase I complex, illustrates the ability of tight binding and inhibition with subnanomolar affinity and indicates the importance of the C-terminal end for the differences in xylanase specificity among different TAXI-type inhibitors. This family also contains pepsin-like aspartic proteinases homologous to TAXI-I. Unlike TAXI-I, they have active site aspartates and are functionally active. This family of aspartate proteases is classified by MEROPS as the peptidase family A1 (pepsin A, clan AA).
Statistics
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PSSM-Id: 133156
View PSSM: cd05489
Aligned: 19 rows
Threshold Bit Score: 362.054
Threshold Setting Gi: 15239656
Created: 8-Feb-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
protein-protein
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:protein-protein interaction interface
Evidence:
  • Structure:1t6g_b, Aspergillus niger xylanase and Triticum aestivum Xylanase inhibitor I complex, contacts determineda at 3.5A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
1T6G_B     16 YTIPFHDG------ASLVLDVAGPLVWSTCdggqp---paeipCSSPTCllanaypapg----cpapscgsdKHDKPCTA 82  bread wheat
CAN68737   59 QKRTPLKP------VPLVLDVNGRSLWVDCesnylsstynapqCHSTQCsranlhdcr-----tcsaqtrpgCHNNTCGL 127 wine grape
ABK95620   46 YLQTPLKP------TKLLLDLGATYTWVNCdgytss-tyqhvpCNSSIAnllgayacld----lcdgppgpnCGNNSFLL 114 black cottonwood
ABD32384   56 HKRTPLMQ------VPVLLDLNGKHLWVNCeqhyasstyqapyCHSTQCsranahtch-----tcvssfrpgCHNNTCGL 124 barrel medic
EAY97995   48 YVTMFRQRtpq-vpVKAVLDLAGTMLWVDCdagyvsssyagvrCGAKPCrllknagcai----tcldapsagCLNDTCSE 122 Indian rice
EAY77143   26 SLYTVSVGg-----APLVVDLAGPLLWSTCppah-----rtvpCSSSVCkvanwyrspascpysdggrpgsgDRGCACAA 95  Indian rice
AAM61574   49 NQRTPLVP------ASVVFDLGGRELWVDCdkgyvsstyqsprCNSAVCsragstscg-----tcfspprpgCSNNTCGG 117 thale cress
CAO22512   48 CLKTPLKP------SKLLLDLGGSFSWVDCykhyvsstyhhipCNSSLCtllslnsca-----hcyrapsptCANDTCAT 116 wine grape
P13917     52 QKRTPLMQ------VPVLVDLNGNHLWVNCeqqyssktyqapfCHSTQCsranthqcl-----scpaasrpgCHKNTCGL 120 soybean
NP_199654  36 NTILPIFTftlntnQEFFIHIGGPYLVRKCndglp---rpivpCGSPVCaltrrftphq----cslpsnkiiNGVCACQA 108 thale cress
Feature 1                                                                                     
1T6G_B     83 YPYNPv------sGACAAGSLshTRFVANTTDGskpv----skvnVGVLAACAPs-kLLASLPRGSTGVAGLANSGLALP 151 bread wheat
CAN68737  128 NAANPi------sGETAFGELaqDVLSIPSTDGsslgq---lvtiPQFLFACAPsslAQKGFPPAVQGVVGLGHTSIALP 198 wine grape
ABK95620  115 FPDNPikpvdykkVKGINIALi-DSFALSTTQGslt-------liNNFIFSCARt-gFLKGLAKGVAGLAALGRSNVSIP 185 black cottonwood
ABD32384  125 MSANPv------tQQTAMGELaqDVLAIYAINGpkpgp---mvtiPQFLFSCAPsflAQKGLPNNVQGVVGLAHSPISLQ 195 barrel medic
EAY97995  123 FPKNTat-----sVSTAGNIIt-DVLSLPTTFRpapgp---lataPAFLFTCGHt-fLTQGLADGATGMVSLSRARFALP 192 Indian rice
EAY77143   96 YPYNP--------VSGQCGRG--DVAAVPLAANatdgknplfpvsFSAFASCAPs-gLLASLPSGVAGVAGMSRLPLSLP 164 Indian rice
AAM61574  118 IPDNTv------tGTATSGEFalDVVSIQSTNGsnpgr---vvkiPNLIFDCGAt-fLLKGLAKGTVGMAGMGRHNIGLP 187 thale cress
CAO22512  117 TLHNSv------tGKSIFHSAlvDAAALPTTDGrnpgr---lallANFAFACSTt-dLLKGLAKGVTGSAGLGWSDLSLP 186 wine grape
P13917    121 MSTNPi------tQQTGLGELgeDVLAIHATQGstqqlg-plvtvPQFLFSCAPsflVQKGLPRNTQGVAGLGHAPISLP 193 soybean
NP_199654 109 TAFEPf------qRICNSDQFtyGDLSISSLKPisps-----vtiNNVYYLCIPq-pFLVDFPPGVFGLAGLAPTALATW 176 thale cress
Feature 1                                                                                     
1T6G_B    152 AQVASaqk-vanRFLLCLpt----ggPGVAIFGGGPvpwp-------------qftqSMPYTPLvtkg-----------g 202 bread wheat
CAN68737  199 TQLAShfg-fqqKFALCLtsp---lnHGVLFLGEAPyrlhpg----------idvshPLGSTPLsis------------r 252 wine grape
ABK95620  186 VQFNRffssspnCFAICLsgs--ksqPGVALFGSKGpydflp---------gidlskSLLYTPLisnpfgkdsdpdkprs 254 black cottonwood
ABD32384  196 NQLSShfg-lkrQFTMCLsrh--pnsNGAILFGDAPnnmhfgqgnnynnknnpnlfnNLVYTPLtit------------q 260 barrel medic
EAY97995  193 TQLADtfg-fsrKFALCLppa---saAGVVVFGDAPytfqpg----------vdlskSLIYTPLlinp----------ek 248 Indian rice
EAY77143  165 SQVASslk-verQFALCLpasg-gggDGAAIFGGGPfqllaap--------pmeiteGLRRNPVpllkn---------pk 225 Indian rice
AAM61574  188 SQFAAafs-fhrKFAVCLts-----gKGVAFFGNGPyvflp-----------giqisSLQTTPLlinpvstasafsqgek 250 thale cress
CAO22512  187 VQFIAgls-lprVFALCLsgs--psaPGVGFYGSAGpyhflp---------eidlskKLIYTPLlvnpygtaldsnhgrp 254 wine grape
P13917    194 NQLAShfg-lqrQFTTCLsry--ptsKGAIIFGDAPnnmrqfq--------nqdifhDLAFTPLtit------------l 250 soybean
NP_199654 177 NQLTRprlglekKFALCLpsdenplkKGAIYFGGGPyklrn-----------idarsMLSYTRLitnp----------rk 235 thale cress
Feature 1                                                                                     
1T6G_B    203 spAHYISArSIVVGdtrvpvp-------egalatGGVMLSTRLPYVLLRPDVYRpLMDAFTKalaaqhangapvaravea 275 bread wheat
CAN68737  253 egEYFIQVtSIRINervvpvnp-----allnrrpGSTLISTTTPYTVLEHSIYQtFTQFYANqmswaprvqpiapf---- 323 wine grape
ABK95620  255 spEYYIGLnSIKVNgkmvalnksl-laidgetgpGGTTISTVVPYTKLQRSIYKtFILAFLKeaaspafnltatkpvk-- 331 black cottonwood
ABD32384  261 qgEYRIHVtSIRLNqhtvvpvsapmlssypegvmGGTLISTSIPYTILQHSLFEaFTQVFAKqyprqaqvnav------- 333 barrel medic
EAY97995  249 stDYFIGLtGIKVNghtvpvnat--llaidkkgvGGTKLSTVSPYTVLERSIHQaVTDAFAKemaaiprapavepf---- 322 Indian rice
EAY77143  226 ngAYYLRVtGIAVNleavpippra-ldldvrrgtGGVTLSTVASYTTLRPDVYRaLLGAFDAatsgipraaavrpf---- 300 Indian rice
AAM61574  251 ssEYFIGVtAIQIVektvpinptl-lkinastgfGGTKISSVNPYTVLESSIYNaFTSEFVKqalarsikrvasvkp--- 326 thale cress
CAO22512  255 sdEYFIGVtALKVNghavdlnpa--lltvdlngnGGTKISTVAPYTVLESSIYEaLTHAFIAesaglnltvhypvkp--- 329 wine grape
P13917    251 qgEYNVRVnSIRINqhsvfplnki-sstivgstsGGTMISTSTPHMVLQQSVYQaFTQVFAQqlpkqaqvksv------- 322 soybean
NP_199654 236 lnNYFLGLkGISVNgnrilfapn--afafdrngdGGVTLSTIFPFTMLRSDIYRvFIEAFSQatsgiprvsst------- 306 thale cress
Feature 1                                                                                     
1T6G_B    276 vapfgvcydtktlgnnlgGYAVPNVQLGLdg--gSDWTMTGKNSMvdvk---qgtACVAFVEMKgvaag--dgrapAVIL 348 bread wheat
CAN68737  324 ----glcfdatkmtatqiGPEVANIDLVLhn-rnNVWRIVGANSMvqpr---pgvWCLGFVDGGsnp-------kaPIIL 388 wine grape
ABK95620  332 --pfgvcypasavkntqmGPAVPIIDLVLdr-qdVVWKIFGSNSMvritkksvdlWCLGFVDAGvnpmvaswiggpSIVI 408 black cottonwood
ABD32384  334 -------gpfgmcfdskrINQALSVEFVMdr-pdVVWRISGENLMvqpr---ngvSCLAFVNGGlhp-------kaAITI 395 barrel medic
EAY97995  323 ----klcydgrkxgstrvGPAVPTVELVLes-taASWVVFGANSMvatk---ggaLCLGVVDAGtep-------qtSVVI 387 Indian rice
EAY77143  301 ----etcyrasalgttrlGFAVANIDLVLgg--gRNWTLPGGSSLvqvd---eqtVCFAFLEMMgtspa--aadspAIVI 369 Indian rice
AAM61574  327 ---fgacfstknvgvtrlGYAVPEIELVLhs-kdVVWRIFGANSMvsvs---ddvICLGFVDGGvna-------rtSVVI 392 thale cress
CAO22512  330 ---frvcfpaddvmettvGPAVPTVDLVMqs-ddVFWRIFGRNSMvrileegvdvWCLGFVDGGvrp-------rtSIVI 398 wine grape
P13917    323 -------apfglcfnsnkINAYPSVDLVMdkpngPVWRISGEDLMvqaq---pgvTCLGVMNGGmqp-------raEITL 385 soybean
NP_199654 307 -------tpfefclstttNFQVPRIDLELan--gVIWKLSPANAMkkvs---ddvACLAFVNGGdaa-------aqAVMI 367 thale cress
Feature 1           #                  
1T6G_B    349 GGAQMEDFVLDFDMEkkRLGFSRLP 373 bread wheat
CAN68737  389 GSYQLEDNLLQFDLArsKLGFSSSL 413 wine grape
ABK95620  409 GGHQLEDNMLQFDLQskRLGFSSSL 433 black cottonwood
ABD32384  396 GSRQLEENMMMFDLArsRLGFTNSL 420 barrel medic
EAY97995  388 GGHMMEDNLLEFDLEasRLGFSSYL 412 Indian rice
EAY77143  370 GGFQMENNLLLFDLEkgTLGISSLL 394 Indian rice
AAM61574  393 GGFQLEDNLIEFDLAsnRFGFSSTL 417 thale cress
CAO22512  399 GGHQMEDNLLQFDLGlkRLGFSSSV 423 wine grape
P13917    386 GARQLEENLVVFDLArsRVGFSTSS 410 soybean
NP_199654 368 GIHQMENTLVEFDVGrsAFGFSSSL 392 thale cress

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