Conserved Protein Domain Family
retropepsin_like_LTR_2

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cd05484: retropepsin_like_LTR_2 
Retropepsins_like_LTR, pepsin-like aspartate proteases.
Retropepsin of retrotransposons with long terminal repeats are pepsin-like aspartate proteases. While fungal and mammalian pepsins are bilobal proteins with structurally related N- and C-termini, retropepsins are half as long as their fungal and mammalian counterparts. The monomers are structurally related to one lobe of the pepsin molecule and retropepsins function as homodimers. The active site aspartate occurs within a motif (Asp-Thr/Ser-Gly), as it does in pepsin. Retroviral aspartyl protease is synthesized as part of the POL polyprotein that contains an aspartyl protease, a reverse transcriptase, RNase H, and an integrase. The POL polyprotein undergoes specific enzymatic cleavage to yield the mature proteins. In aspartate peptidases, Asp residues are ligands of an activated water molecule in all examples where catalytic residues have been identified. This group of aspartate peptidases is classified by MEROPS as the peptidase family A2 (retropepsin family, clan AA), subfamily A2A.
Statistics
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PSSM-Id: 133151
View PSSM: cd05484
Aligned: 22 rows
Threshold Bit Score: 106.522
Threshold Setting Gi: 170052543
Created: 4-Apr-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
catalytic motifCatalytic
Feature 1:catalytic motif [active site]
Evidence:
  • Comment:conserved catalytic motif DT/SG of retropepsin.
  • Citation:PMID 7664111

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                         ###                                                             
CAJ00232      336 KYVTIFFdGKPVKLQVDTGSDITLISRETWIKIgrpr-yqpTCHNAKSASGTNITLLGvi---qLPLTFGEKt-MTGKCY 410  Schistosoma m...
XP_001638189   50 WKAEIEVnGQPITFKLDNGAAVSVISDQEPLINsye--lvkPKEVLRGPGGSRLSVLGic--idTCLKAQGKe-MKETLY 124  starlet sea a...
XP_001842067  312 KFLTVSInGSQASLQFDTGSDITVISRKQWCDNldspplspTKQIARTASGKSLSLLGel---rCQVTLGGVt-ITGTFY 387  southern hous...
AAX26324      174 KFVSLLVnGKPIRLQLDTASDITLISKNTWRKLgcpr-iqpTEHVARNASGDIVKLTGei---mCEVQFRKH--KFIDVC 247  Schistosoma j...
XP_001191653  268 WSSSILVdGNETHFKLDTGAAVTVLSDSTPWLNkhi--mrpTTKRLRGPGSTVLTVIGqm---tSTLRHRDKq-IKETLY 341  purple urchin
NP_494296     358 PSLRLNVeGQQIDFTFDTGSDITLISVQNWQKIgkph-lekVHHKICCANGTEIAVKGrv---lVWFKVKGV--EYTEYV 431  nematode
XP_001869922   38 KGAETAIyGVPLDLQLDSGSGITIISRQNWVNVgspp-tspPDCNVQTASGDKLGIEAmf---rATYTIGGTh-KESNCY 112  southern hous...
Q09575        291 HRMSVEVcGKDVAFQLDTGSMITLISVKCWEKLgspp-lekVPHRISCANGTPMAVKGr-----CLVKFKLKgiEYTEYV 364  nematode
XP_001202124  414 WGAYLQVdGNTTHFKLDSGAAVTVLSDGLQWLRgik--lkpANKRLCGPGKTKLEVLGqi---kAILQHKNRr-VSETVY 487  purple urchin
XP_001624783  164 WSVELLVnGNASDFKLDSGSKVTVVSDQTPWIKgmq--leeVKTEFRGPGGVKLSHLMkgqipnATFQAGDKa-QHENVY 240  starlet sea a...
Feature 1                          
CAJ00232      411 VSgnc-htNLLGIDWID 426  Schistosoma mansoni
XP_001638189  125 VIknq-lhSLLSRNACV 140  starlet sea anemone
XP_001842067  388 VTdk--qiNLFGLDWIE 402  southern house mosquito
AAX26324      248 YLtnrhdlDLLGLDWIE 264  Schistosoma japonicum
XP_001191653  342 VVkdq-esSLLSRKACR 357  purple urchin
NP_494296     432 YVwnr-nnNLLGTSWMR 447  nematode
XP_001869922  113 VCsadlslNVLGSDLMD 129  southern house mosquito
Q09575        365 YVrdr-qtNLLGTSWLN 380  nematode
XP_001202124  488 VVrnq-dcSLLSRKACE 503  purple urchin
XP_001624783  241 VMgnq-rnNLLSKCGTR 256  starlet sea anemone

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