Conserved Protein Domain Family
retropepsin_like_LTR_1

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cd05481: retropepsin_like_LTR_1 
Retropepsins_like_LTR; pepsin-like aspartate protease from retrotransposons with long terminal repeats.
Retropepsin of retrotransposons with long terminal repeats are pepsin-like aspartate proteases. While fungal and mammalian pepsins are bilobal proteins with structurally related N and C-terminals, retropepsins are half as long as their fungal and mammalian counterparts. The monomers are structurally related to one lobe of the pepsin molecule and retropepsins function as homodimers. The active site aspartate occurs within a motif (Asp-Thr/Ser-Gly), as it does in pepsin. Retroviral aspartyl protease is synthesized as part of the POL polyprotein that contains an aspartyl protease, a reverse transcriptase, RNase H, and an integrase. The POL polyprotein undergoes specific enzymatic cleavage to yield the mature proteins. In aspartate peptidases, Asp residues are ligands of an activated water molecule in all examples where catalytic residues have been identified. This group of aspartate peptidases is classified by MEROPS as the peptidase family A2 (retropepsin family, clan AA), subfamily A2A.
Statistics
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PSSM-Id: 133148
View PSSM: cd05481
Aligned: 29 rows
Threshold Bit Score: 68.8279
Threshold Setting Gi: 115695257
Created: 17-Jan-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
catalytic motifCatalytic
Feature 1:catalytic motif [active site]
Evidence:
  • Comment:conserved catalytic motif DT/SG of retropepsin.
  • Citation:PMID 7664111

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                         ###                                                             
XP_795582     486 CPHKSGQ--HYLYLKIDSGASANTITVRTakqiygdkwrqvvkrTPVKLVAYGEISIPCVgt----ldIKCRYKSPe--- 556  purple urchin
XP_797754     331 QEIIIDDd-VCVDFKLDSGAQVNILPENIfrktk-----lsldkTPVTLRSYSRHIMKPVgk----trCKVLVGKHe--- 397  purple urchin
XP_001620861   55 ASMQLRD--EQVKFQLDCGATVNILPIDKyvqifndpsharlkkTNKTLQMFNKTELKPIg------tVKIESVNPk--- 123  starlet sea a...
XP_001182107  302 VKLVVNN--RLVIFKLDTGAQTNLLPESVyqslip---rpklhpARVRLTGYSGVVIPVKgr----cyVQVEYKGLt--- 369  purple urchin
XP_781838     305 AEMMIDD--NPVKFQIDSGATVNVIPKKYvksk--------idtRDAELRMYNETTLMAEg------rVKIILRNPknk- 367  purple urchin
XP_001203881  347 ARMMINE--KAVDFQVDSGASANILPLRHlegad-----yvlkpSKKKLMMWNEITMAIEg------vSRVKMLNPktk- 412  purple urchin
XP_780984     234 AEMLVEN--RPANFQIDSGASVNVISKSLvpsae------divkENIILKMYNRSRLQAEg------rAKVVLRNTknn- 298  purple urchin
XP_785392     193 AKFRINDe-DEIGMQVDCGATCNVIHLEDvpsgt------eltsTNQVLIVYGQGTVPVAg------kCKLHLRNVknn- 258  purple urchin
XP_796031     226 AAFLIRG--NKISMQVDSGATCNVIPKRHvpdnv------einyGTRRLSLYGNKATVDGig-----vCNIVLKNPknh- 291  purple urchin
XP_001863351  311 WFEEAVIdnLKVKFKLDCGAQCNVLPLKVakritn----klqrsKTKYIVSYSGEKTKVEgdlttaanYKDTKSNTrgvt 386  southern hous...
Feature 1                                   
XP_795582     557 --wYTHTFYVAdvn-gpAILWLLGCT 579  purple urchin
XP_797754     398 ---YLLTFQVVggy-gkPLIGRRDCE 419  purple urchin
XP_001620861  124 --nEDAILLVVnqg-hrPILGAQAIQ 146  starlet sea anemone
XP_001182107  370 ---HNMAVLVTpgd-rqPLLGLQACE 391  purple urchin
XP_781838     368 -kkYRVDFMVVkennrvPLLGRNTSE 392  purple urchin
XP_001203881  413 -qkYSVEFIVVdkd-ftPLLGSTVSQ 436  purple urchin
XP_780984     299 -kkYRVNFIVVken-lvPLLSGPAAQ 322  purple urchin
XP_785392     259 -krYLVPFVVVkgevtrPLLGASTGQ 283  purple urchin
XP_796031     292 -rkYDVKFVVVhed-ctPLIGARMSQ 315  purple urchin
XP_001863351  387 lrfCRCWNHELra--stELVGASTEL 410  southern house mosquito

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