Conserved Protein Domain Family
NRIP_C

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cd05480: NRIP_C 
NRIP_C; putative nuclear receptor interacting protein.
Proteins in this family have been described as probable nuclear receptor interacting proteins. The C-terminal domain of this family is homologous to the retroviral aspartyl protease domain. The domain is structurally related to one lobe of the pepsin molecule. The conserved active site aspartate occurs within a motif (Asp-Thr/Ser-Gly), as it does in pepsin. Asp residues are ligands of an activated water molecule in all examples where catalytic residues have been identified. This group of aspartate peptidases is classified by MEROPS as the peptidase family A2 (retropepsin family, clan AA), subfamily A2A.
Statistics
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PSSM-Id: 133147
View PSSM: cd05480
Aligned: 4 rows
Threshold Bit Score: 147.311
Threshold Setting Gi: 122064616
Created: 29-Feb-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
catalytic motifCatalytic
Feature 1:catalytic motif [active site]
Evidence:
  • Comment:conserved catalytic motif DT/SG of retropepsin.
  • Citation:PMID 7664111

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                      ###                                                               
Q9BQI9       112 VNCKCqdQLLRVAVDTGTQYNRISAGCLSRLGLeKRVLKASAGDLAPGPPTQVEq------LELQLGqeTVVCSAQVVDa 185 human
NP_001088320 115 VCCQCagMEVRALIDTSCQYSLIPAPCLDRLGLkEHFRLYKKEEEPPSLPYSVKaigqverVAVMLGgaTVECTAIVIDn 194 African clawed ...
XP_420983    115 VSCQCagKELKAVVDTGSQHNLMSAACLDRLGLrERLEVLPSEEEEISLAHSERvigridrLVLAVGalRVECAALVVEd 194 chicken
Q9NQ35       110 VSCQCagKDVKALVDTGCLYNLISLACVDRLGLkEHVKSHKHEGEKLSLPRHLKvvgqiehLVITLGslRLDCPAAVVDd 189 human
Feature 1                               
Q9BQI9       186 espeFCLGLQTLLSLKCCIDLEH 208 human
NP_001088320 195 ndrnLSLGLQTLKSLKCVINLEK 217 African clawed frog
XP_420983    195 sekpFSFGLQTLKSLKCVINLEK 217 chicken
Q9NQ35       190 neknLSLGLQTLRSLKCIINLDK 212 human

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