Conserved Protein Domain Family
nucellin_like

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cd05475: nucellin_like 
Nucellins, plant aspartic proteases specifically expressed in nucellar cells during degradation.
Nucellins are important regulators of nucellar cell's progressive degradation after ovule fertilization. This degradation is a characteristic of programmed cell death. Nucellins are plant aspartic proteases specifically expressed in nucellar cells during degradation. The enzyme is characterized by having two aspartic protease catalytic site motifs, the Asp-Thr-Gly-Ser in the N-terminal and Asp-Ser-Gly-Ser in the C-terminal region, and two other regions nearly identical to two regions of plant aspartic proteases. Aspartic proteases are bilobal enzymes, each lobe contributing a catalytic Asp residue, with an extended active site cleft localized between the two lobes of the molecule. One lobe may be evolved from the other through ancient gene-duplication event. Although the three-dimensional structures of the two lobes are very similar, the amino acid sequences are more divergent, except for the conserved catalytic site motif.
Statistics
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PSSM-Id: 133142
View PSSM: cd05475
Aligned: 9 rows
Threshold Bit Score: 416.387
Threshold Setting Gi: 2290202
Created: 13-Feb-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
catalytic motifcatalyticActive site
Feature 1:catalytic motif [active site]
Evidence:
  • Comment:Catalytic motif in both N- and C-terminal lobes of this family.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                              ####                                                      
AAM64443      58 GYYNVTINIGQPP--RPYYLDLDTGSDLTWLQCDAPCVRCleaphplyqpssdlipcnd----------plckalhlnsn 125 thale cress
EDQ51645      29 GLYYMAMRIGNPA--KLYYLDMDTGSDLTWLQCDAPCRSCavgphglydpkrarvvdcrr--------ptcaqvqrggqf 98  Physcomitrella ...
NP_564539    201 GLYYTRILVGKPEdgQYYHLDIDTGSELTWIQCDAPCTSCakganqlykprkdnlvrsse--------afcvevqrnqlt 272 thale cress
NP_001048015 201 GQYYTSIFVGNPP--RPYFLDVDTGSDLTWIQCDAPCTNCakgphplykpakekivppk----------dllcqelqgnq 268 Japanese rice
CAO61887      60 GFYSVSLRIGNPP--KPYTLDIDSGSDLTWLQCDAPCVSCtkaphppykpnkgpitcnd---------pmcsalhwpskp 128 wine grape
NP_175079     47 GYYSVLMQIGSPP--KAFQFDIDTGSDLTWVQCDAPCSGCtlppnlqykpkgniipcsn---------pictalhwpnkp 115 thale cress
A2ZC67        36 GHFFVTMNIGDPA--KPYFLDIDTGSTLTWLQCDYPCINCnkvphglykpelkyavkcte-------qrcadlyadlrkp 106 Indian rice
AAG51657      65 GYYYVLLNIGNPP--KLFDLDIDTGSDLTWVQCDAPCNGCtkykpnhntlpcshilc--------------sgldlpqdr 128 thale cress
AAB96882      36 GHFYATLNIGEPA--KPYFLDVDTGSNLTWLECHHPVHGCkgchprpphpyytpadgnlkvvcgsplcvavrrdvpgipe 113 domesticated ba...
Feature 1                                                                                        
AAM64443     126 qrcetpeQCDYEVEYAdGGSSLGVLVRDVFSMnytqglrltpRLALGCGYDQipgas-shhpLDGVLGLGRGKVSILSQL 204 thale cress
EDQ51645      99 tcsgdvrQCDYEVDYVdGSSTMGILVEDTITLvltngtrfqtRAVIGCGYDQqgtlakapavTDGVIGLSSSKISLPSQL 178 Physcomitrella ...
NP_564539    273 ehcenchQCDYEIEYAdHSYSMGVLTKDKFHLklhngslaesDIVFGCGYDQqglllntllkTDGILGLSRAKISLPSQL 352 thale cress
NP_001048015 269 nycetckQCDYEIEYAdRSSSMGVLARDDMHIittnggreklDFVFGCAYDQqgqllaspakTDGILGLSSAGISLPSQL 348 Japanese rice
CAO61887     129 pckasheQCDYEVSYAdHGSSLGVLVHDIFSLqltngtlaapRLAFGCGYDQsypgpnappfVDGVLGLGYGKSSIVTQL 208 wine grape
NP_175079    116 hcpnpqeQCDYEVKYAdQGSSMGALVTDQFPLklvngsfmqpPVAFGCGYDQsypsahpppaTAGVLGLGRGKIGLLTQL 195 thale cress
A2ZC67       107 mkcgpknQCHYGIQYV-GGSSIGVLIVDSFSLpasng-tnptSIAFGCGYNQgknnhnvptpVNGILGLGRGKVTLLSQL 184 Indian rice
AAG51657     129 pcadpedQCDYEIGYSdHASSIGALVTDEVPLklangsimnlRLTFGCGYDQqnpgphppppTAGILGLGRGKVGLSTQL 208 thale cress
AAB96882     114 csrndphRCHYEIQYV-TGKSEGDLATDIISVngr----dkkRIAFGCGYKQeepadsppspVDGILGLGMGKAGFAAQL 188 domesticated ba...
Feature 1                                                                                        
AAM64443     205 HSQGyv-kNVIGHCLss--lGGGILFFGDDLydssRVSWTPMsre----------yskHYSPAMggellfgg----rttg 267 thale cress
EDQ51645     179 AAKGia-nNVIGHCLaggsnGGGYLFFGDTLvpalGMTWTPMigrp---------lveGYQARLrsikyggevlelegtt 248 Physcomitrella ...
NP_564539    353 ASRGii-sNVVGHCLasdlnGEGYIFMGSDLvpshGMTWVPMlhdsrldayqmqvtkmSYGQGMlsldge---------n 422 thale cress
NP_001048015 349 ANQGii-sNVFGHCItrdpnGGGYMFLGDDYvprwGMTSTPIrsapdnlf-hteaqkvYYGDQQlsmrga---------s 417 Japanese rice
CAO61887     209 RSLGli-rSIVGHCLsg--rGGGFLFLGDGLsttpGIIWTPMsrks---------gesAYALGPadllfngq-----nsg 271 wine grape
NP_175079    196 VSAGlt-rNVVGHCLss--kGGGFLFFGDNLvpsiGVAWTPLlsq-----------dnHYTTGPadllfngk-----ptg 256 thale cress
A2ZC67       185 KSQGvitkHVLGHCIss--kGKGFLFFGDAKvptsGVTWSPMnre-----------hkHYSPRQgtlqfnsns---kpis 248 Indian rice
AAG51657     209 KSLGit-kNVIVHCLsh--tGKGFLSIGDELvpssGVTWTSLatns---------pskNYMAGPaellfndk-----ttg 271 thale cress
AAB96882     189 KGHKmikeNVIGHCLss--kGKGVLYVGDFNpptrGVTWAPMres-----------lfYYSPGLaevfidkq----pirg 251 domesticated ba...
Feature 1                ####                                                                    
AAM64443     268 lknlLTVFDSGSSYTYFNSKAYqavtyllkrelsgkplkeardd---htlplcwqgrrpfmsieevkkyFKPLALSFktg 344 thale cress
EDQ51645     249 ddvgGAMFDSGTSFTYLVPNAYtavlsavvrqaqrsgleriktd---ttlpfcwrgpspfesvadvsayFKTVTLDFggs 325 Physcomitrella ...
NP_564539    423 grvgKVLFDTGSSYTYFPNQAYsqlvtslqevsgleltrddsdet--lpicwraktnfpfsslsdvkkfFRPITLQIgsk 500 thale cress
NP_001048015 418 gnsvQVIFDSGSSYTYLPDEIYknliaaikyaypnfvqdssdr-----tlplclatdfpvryledvkqlFKPLNLHFgkr 492 Japanese rice
CAO61887     272 vkglRLVFDSGSSYTYFNAQAYkttlslvrkylngklketade-----slpvcwrgakpfksifevknyFKPFALSFtka 346 wine grape
NP_175079    257 lkglKLIFDTGSSYTYFNSKAYqtiinligndlkvsplkvaked---ktlpicwkgakpfksvlevknfFKTITINFtng 333 thale cress
A2ZC67       249 aapmEVIFDSGATYTYFALQPYhatlsvvkstlskeckfltevkekdraltvcwkgkdkirtidevkkcFRSLSLKFadg 328 Indian rice
AAG51657     272 vkgiNVVFDSGSSYTYFNAEAYqaildlirkdlngkpltdtkdd---kslpvcwkgkkplksldevkkyFKTITLRFgnq 348 thale cress
AAB96882     252 nptfEAVFDSGSTYTHVPAQIYneivskvrgtlsessleevkgr----alplcwkgkkpfgsvndvknqFKALSLKItha 327 domesticated ba...
Feature 1                                                                                
AAM64443     345 wrsk--tlfeipPEAYLIISmkGNVCLGILNGteig---lqnLNLIGDISMQDQMIIYDNekqSIGWMPVDC 411 thale cress
EDQ51645     326 twwssgkllelsPEGYLIVStqGNVCLGVLDAsvas---levTNILGDISMRGYLVVYDNmreQIGWVRRNC 394 Physcomitrella patens s...
NP_564539    501 wlii-srklliqPEDYLIISnkGNVCLGILDGssvh---dgsTIILGDISMRGHLIVYDNvkrRIGWMKSDC 568 thale cress
NP_001048015 493 wfvm-prtftilPDNYLIISdkGNVCLGFLNGkdid---hgsTVIVGDNALRGKLVVYDNqqrQIGWTNSDC 560 Japanese rice
CAO61887     347 ksa----qlqlpPESYLIISkhGNACLGILNGsevg---lgdSNVIGDIAFQDKMVIYDNerqQIGWVPKDC 411 wine grape
NP_175079    334 rrn---tqlylaPELYLIVSktGNVCLGLLNGsevg---lqnSNVIGDISMQGLMMIYDNekqQLGWVSSDC 399 thale cress
A2ZC67       329 dkk---atleipPEHYLIISqeGHVCLGILDGskehp-slagTNLIGGITMLDQMVIYDSersLLGWVNYQC 396 Indian rice
AAG51657     349 kng---qlfqvpPESYLIITekGRVCLGILNGteig---legYNIIGDISFQGIMVIYDNekqRIGWISSDC 414 thale cress
AAB96882     328 rgt---nnldipPQNYLFVKedGETCLAILDAsldpvlkelnFILIGAVTMQDLFVIYDNekkQLGWVRAQC 396 domesticated barley

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