Conserved Protein Domain Family
cnd41_like

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cd05472: cnd41_like 
Chloroplast Nucleoids DNA-binding Protease, catalyzes the degradation of ribulose-1,5-bisphosphate carboxylase/oxygenase.
Chloroplast Nucleoids DNA-binding Protease catalyzes the degradation of ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) in senescent leaves of tobacco. Antisense tobacco with reduced amount of CND41 maintained green leaves and constant protein levels, especially Rubisco. CND41 has DNA-binding as well as aspartic protease activities. The pepsin-like aspartic protease domain is located at the C-terminus of the protein. The enzyme is characterized by having two aspartic protease catalytic site motifs, the Asp-Thr-Gly-Ser in the N-terminal and Asp-Ser-Gly-Ser in the C-terminal region. Aspartic proteases are bilobal enzymes, each lobe contributing a catalytic Asp residue, with an extended active site cleft localized between the two lobes of the molecule. One lobe may be evolved from the other through ancient gene-duplication event. This family of aspartate proteases is classified by MEROPS as the peptidase family A1 (pepsin A, clan AA).
Statistics
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PSSM-Id: 133139
View PSSM: cd05472
Aligned: 23 rows
Threshold Bit Score: 368.908
Threshold Setting Gi: 125555043
Created: 31-Mar-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:catalytic residue [active site]
Evidence:
  • Comment:The two ASPs at the active site plays key catalytic roles in the pepsin family and conserved for all family members.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                        #                                                            
NP_171637 141 EYFTRLGVGTParYVYMVLDTGSDIVWLQCAPCrrcysqsdpifdprksktyati---------pcssphcrrldsagcn 211 thale cress
BAD62398  143 EFVVAVGLGTPaqPSALIFDTGSDLSWVQCQPCgssghchpqqdplfdpsksstya-------avhcgepqcaaagdlcs 215 Japanese rice
CAB96832  103 NYIVTVGLGTPknDLSLIFDTGSDLTWTQCQPCvrtcydqkepifnpskstsyynvs-----cssaacgslssatgnags 177 thale cress
NP_565219 134 NYIVTVELGGK--NMSLIVDTGSDLTWVQCQPCrscynqqgplydpsvsssyktvfcnsstcqdlvaatsnsgpcggnng 211 thale cress
EAY87322  130 QYVVTVSLGTPavAQTLEVDTGSDVSWVQCKPCpsppcysqrdplfdptrsssysa-------vpcaaascsqlalysng 202 Indian rice
EAZ09144  125 NYVATVGLGGG--EATVIVDTASELTWVQCAPCaschdqqgplfdpasspsyavlpcn--ssscdalqvatgsaagacgg 200 Indian rice
EAY74910  176 EYVISVGLGSPamTQRVVIDTGSDVSWVQCEPCpapspchahagalfdpaasstyaaf---ncsaaacaqlgdsgeangc 252 Indian rice
EAZ09523  148 NYVVSVGLGTPakQYAVIFDTGSDLSWVQCKPCadcyeqqdplfdpslsstyaa----------vacgapecqeldasgc 217 Indian rice
EAY99437   67 ATTNSAPDGTSavSQTVIIDSGSDVPWVQCQPCpllvchpqrdplfdpatsttyaa------vpcssaacarlgpyrrgc 140 Indian rice
EAZ01642  281 NYVVTVGLGTPasRYTVVFDTGSDTTWVQCQPCvvacyeqreklfdpassstya----------nvscaapacsdldvsg 350 Indian rice
Feature 1                                                                                     
NP_171637 212 trrktCLYQVSYGDGSFTVGDFsTETLTFrrn-rvkGVALGCGHDNEGLFv--gAAGLLGLGKGKLSFPGQTGHrfnqKF 288 thale cress
BAD62398  216 ednttCLYLVRYGDGSSTTGVLsRDTLALtssraltGFPFGCGTRNLGDFg--rVDGLLGLGRGELSLPSQAAAsfgaVF 293 Japanese rice
CAB96832  178 csasnCIYGIQYGDQSFSVGFLaKEKFTLtnsdvfdGVYFGCGENNQGLFt--gVAGLLGLGRDKLSFPSQTATaynkIF 255 thale cress
NP_565219 212 vvktpCEYVVSYGDGSYTRGDLaSESILLgdt-kleNFVFGCGRNNKGLFg--gSSGLMGLGRSSVSLVSQTLKtfngVF 288 thale cress
EAY87322  203 csggqCGYVVSYGDGSTTTGVYsSDTLTLtgsnalkGFLFGCGHAQQGLFa--gVDGLLGLGRQGQSLVSQASStyggVF 280 Indian rice
EAZ09144  201 geqpsCSYTLSYRDGSYSQGVLaHDKLSLage-vidGFVFGCGTSNQGPFg--gTSGLMGLGRSQLSLISQTMDqfggVF 277 Indian rice
EAY74910  253 daksrCQYIVKYGDGSNTTGTYsSDVLTLsgsdvvrGFQFGCSHAELGAGmddkTDGLIGLGGDAQSLVSQTAArygkSF 332 Indian rice
EAZ09523  218 ssdsrCRYEVQYGDQSQTDGNLvRDTLTLsasdtlpGFVFGCGDQNAGLFg--qVDGLFGLGREKVSLPSQGAPsygpGF 295 Indian rice
EAY99437  141 lansqCQFGITYANGATATGTYsSDDLTLgpydvvrGFLFGCAHADQGSTfsydVAGTLALGGGSQSFVQQTASqysrVF 220 Indian rice
EAZ01642  351 csgghCLYGVQYGDGSYSIGFFaMDTLTLssydavkGFRFGCGERNDGLFg--eAAGLLGLGRGKTSLPVQTYGkyggVF 428 Indian rice
Feature 1                                                                                     
NP_171637 289 SYCLVdrsasskPSSVVFGNAav-----srIARFTPLlsnp-kldtFYYVGLLGISVGGtrvpgvtaslfkldqigngGV 362 thale cress
BAD62398  294 SYCLPssn--stTGYLTIGATpat---dtgAAQYTAMlrkp-qfpsFYFVELVSIDIGGyvlpvpp------avftrgGT 361 Japanese rice
CAB96832  256 SYCLPssa--syTGHLTFGSAgi-----srSVKFTPIstit-dgtsFYGLNIVAITVGGqklpips------tvfstpGA 321 thale cress
NP_565219 289 SYCLPsle-dgaSGSLSFGNDssvy-tnstSVSYTPLvqnp-qlrsFYILNLTGASIGGvelks---------ssfgrGI 356 thale cress
EAY87322  281 SYCLPptq--nsVGYISLGGPss-----taGFSTTPLltas-ndptYYIVMLAGISVGGqplsid-------asvfasGA 345 Indian rice
EAZ09144  278 SYCLPlke-sesSGSLVLGDDtsvy-rnstPIVYTTMvsdp-vqgpFYFVNLTGITIGGqeve-----------ssagKV 343 Indian rice
EAY74910  333 SYCLPatp--asSGFLTLGAPasgggggasRFATTPMlrsk-kvptYYFAALEDIAVGGkklgls-------psvfaaGS 402 Indian rice
EAZ09523  296 TYCLPsss--sgRGYLSLGGApp------aNAQFTALadga--tpsFYYIDLVGIKVGGrairipa-----tafaaagGT 360 Indian rice
EAY99437  221 SYCVPpst--ssFGFIMFGVPpqra-alvpTFVSTPLlssstmsptFYRVLLRSIIVAGrplpvp-------ptvfsaSS 290 Indian rice
EAZ01642  429 AHCLPars--tgTGYLDFGAGsp------pATTTTPMltgn--gptFYYVGMTGIRVGGrllpiap------svfaaaGT 492 Indian rice
Feature 1       #                                                                             
NP_171637 363 IIDSGTSVTRLIRPAYIAMRDAFrvgaktl--krapdfsLFDTCFDLSNmnevkVPTVVLHFr-GADVSLpatnyli-pv 438 thale cress
BAD62398  362 LLDSGTVLTYLPAQAYALLRDRFrltmery--tpappndVLDACYDFAGesevvVPAVSFRFgdGAVFELdffgvmi--f 437 Japanese rice
CAB96832  322 LIDSGTVITRLPPKAYAALRSSFkakmsky--pttsgvsILDTCFDLSGfktvtIPKVAFSFsgGAVVELgskgify--v 397 thale cress
NP_565219 357 LIDSGTVITRLPPSIYKAVKIEFlkqfsgf--ptapgysILDTCFNLTSyedisIPIIKMIFqgNAELEVdvtgvfyfvk 434 thale cress
EAY87322  346 VVDTGTVVTRLPPTAYSALRSAFraamapygypsapatgILDTCYDFTRygtvtLPTISIAFggGAAMDLgtsg------ 419 Indian rice
EAZ09144  344 IVDSGTIITSLVPSVYNAVKAEFlsqfaey--pqapgfsILDTCFNLTGfrevqIPSLKFVFegNVEVEVdssgvlyfvs 421 Indian rice
EAY74910  403 LVDSGTVITRLPPAAYAALSSAFragmtry--araeplgILDTCFNFTGldkvsIPTVALVFagGAVVDLdahg------ 474 Indian rice
EAZ09523  361 VIDSGTVITRLPPRAYAPLRAAFarsmaqy--kkapalsILDTCYDFTGhrtaqIPTVELAFagGATVSLdftgvly--v 436 Indian rice
EAY99437  291 VIDSATVISRIPPTAYQALRAAFrsamtmy--rpappvsILDTCYDFSGvrsitLPSIALVFdgGATVNLdaag------ 362 Indian rice
EAZ01642  493 IVDSGTVITRLPPAAYSSLRSAFaaamaargyrkaaavsLLDTCYDFTGmsqvaIPTVSLLFqgGAALDVdasgimy--t 570 Indian rice
Feature 1                                                      
NP_171637 439 dtngkFCFAFagt---mggLSIIGNIQQQGFRVVYDLassRVGFAPGGC 484 thale cress
BAD62398  438 ldenvGCLAFaamdtgglpLSIIGNTQQRSAEVIYDVaaeKIGFVPASC 486 Japanese rice
CAB96832  398 fkisqVCLAFagns-ddsnAAIFGNVQQQTLEVVYDGaggRVGFAPNGC 445 thale cress
NP_565219 435 pdaslVCLALasls-yeneVGIIGNYQQKNQRVIYDTtqeRLGIVGENC 482 thale cress
EAY87322  420 -iltsGCLAFaptg-gdsqASILGNVQQRSFEVRFDGs--TVGFMPASC 464 Indian rice
EAZ09144  422 sdssqVCLALaslk-seyeTSIIGNYQQKNLRVIFDTlgsQIGFAQETC 469 Indian rice
EAY74910  475 -ivsgGCLAFaptr-ddkaFGTIGNVQQRTFEVLYDVgggVFGFRAGAC 521 Indian rice
EAZ09523  437 skvsqACLAFapna-ddssIAILGNTQQKTFAVTYDVanqRIGFGAKGC 484 Indian rice
EAY99437  363 -illqGCLAFapta-sdrmPGFIGNVQQRTLEVVYDVpgkAIRFRSAAC 409 Indian rice
EAZ01642  571 vsasqVCLAFagne-dggdVGIVGNTQLKTFGVAYDIgkkVVGFSPGAC 618 Indian rice

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