1MYP,2E9E,1PTH


Conserved Protein Domain Family
An_peroxidase_like

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cd05396: An_peroxidase_like 
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Animal heme peroxidases and related proteins.
A diverse family of enzymes, which includes prostaglandin G/H synthase, thyroid peroxidase, myeloperoxidase, linoleate diol synthase, lactoperoxidase, peroxinectin, peroxidasin, and others. Despite its name, this family is not restricted to metazoans: members are found in fungi, plants, and bacteria as well.
Statistics
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PSSM-Id: 188647
Aligned: 17 rows
Threshold Bit Score: 248.881
Created: 26-Apr-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
heme bindingsubstrate
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:heme binding site [chemical binding site]
Evidence:
  • Structure:2E9E: goat Lactoperoxidase binds protoporphyrin IX, contacts at 4 A
  • Structure:1PTH: sheep PGHS-1 binds heme, contacts at 4 A
  • Citation:PMID 8121489
  • Citation:PMID 7552725

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                      
1MYP_C      51 QINALTs-fVDASMVYGSEEPLARNLRnms-------nqLGLLAVNqrfq------------------------------ 92   human
2E9E_A     179 QINAVTs-fLDASLVYGSEPSLASRLRnls-------spLGLMAVNqeaw------------------------------ 220  goat
1PTH_A     195 GFTKALghgVDLGHIYGDNLERQYQLRlf---------kDGKLKYQmlngev---------------------------- 237  sheep
NP_744706  227 QPNTTSp-fVDQSQTYSSHPSHQVFLReytvnaagdpvaTGRLITNrdlgadgkfgtaddgngesggmatwavvkaqard 305  Pseudomonas puti...
O82031     215 HLNTRTp-wWDGSAIYGSNAEVLKKVRtf---------kDGKLKLSa--------------------------------- 251  common tobacco
Q9UUS2     214 NINLTSs-yLDLSPLYGRNHDEQMAVRtg---------kDGLLKPDtfss------------------------------ 253  Gaeumannomyces g...
YP_783237  106 VENFRTp-aLDLDSIYGLGPDGSRQLYarnppdfdgknpGPFLLIGetipggpg-------------------------- 158  Rhodopseudomonas...
EEH35462   272 NVNMATt-wLDISSLYGSTSDVARAVRsy---------kDGKLLTQevkag----------------------------- 312  Paracoccidioides...
EEH44179   236 NVNMATt-wLDISSLYGSTSDVARAIRsy---------kNGKLLTQevkag----------------------------- 276  Paracoccidioides...
EEN62449   180 QLNEITp-yLDGGLMYGVTKAWADALRlfs------edrPGRLISCgdqghaec-------------------------- 226  Florida lancelet
Feature 1                                                                                      
1MYP_C         --------------------------------------------------------------------------------      human
2E9E_A         --------------------------------------------------------------------------------      goat
1PTH_A         --------------------------------------------------------------------------------      sheep
NP_744706  306 llginltdadvhsvpllatdaygnflrgpngmpqvvmrvnngadgiagtaddvtqlvegdrnapislanavstghgfldd 385  Pseudomonas puti...
O82031         --------------------------------------------------------------------------------      common tobacco
Q9UUS2         --------------------------------------------------------------------------------      Gaeumannomyces g...
YP_783237      --------------------------------------------------------------------------------      Rhodopseudomonas...
EEH35462       --------------------------------------------------------------------------------      Paracoccidioides...
EEH44179       --------------------------------------------------------------------------------      Paracoccidioides...
EEN62449       --------------------------------------------------------------------------------      Florida lancelet
Feature 1                                                                              ##      
1MYP_C      93 -----------------------------------dngRALLPFdnlhddpclltnrsaripCFLAGDTRSSEMPELTSM 137  human
2E9E_A     221 -----------------------------------dhgLAYPPFnnvkpspcefinttahvpCFQAGDSRASEQILLATV 265  goat
1PTH_A     238 --------------------------------yppsveEAPVLMhyprg--------ippqsQMAVGQEVFGLLPGLMLY 277  sheep
NP_744706  386 iahnaapvvvggalqadadtlvgnaqpvgqggnnltydNELLDA------------------HYIAGDGRVNENIGLTAV 447  Pseudomonas puti...
O82031     252 --------------------------------------DGLLEIdk---------------nGKIISGDVRNTWAGLSAL 278  common tobacco
Q9UUS2     254 -----------------------------------krvIGFPPGvga------------fliMFNRFHNYVVTQLAKINE 286  Gaeumannomyces g...
YP_783237  159 -------------------------------gltdsfpNDLPRSpe---------------gFALIGDHRNDENLLVAQT 192  Rhodopseudomonas...
EEH35462   313 ---------------------------------nmslaTSYLPFnswnvsmrt-tpgldpttLFTGGDPRTNEDWLVLAV 358  Paracoccidioides...
EEH44179   277 ---------------------------------nmslaTSYLPFnswnvsmrt-tpgldpttLFTGGDPRTNEDWLVLAV 322  Paracoccidioides...
EEN62449   227 ------------------------------gdlypaynTLGLPFanpppprd--hilkpsyrFFKIGNPRGNENPFLLTF 274  Florida lancelet
Feature 1                                                                                      
1MYP_C     138 HTLLLREHNRLATELkslnp-----------------------------rwdgeRLYQEARKIVGAMVQIITYRDYLPLV 188  human
2E9E_A     266 HTLLLREHNRLARELkrlnp-----------------------------hwdgeMLYQEARKILGAFIQIITFRDYLPIV 316  goat
1PTH_A     278 ATIWLREHNRVCDLLkaehp-----------------------------twgdeQLFQTARLILIGETIKIVIEEYVQQL 328  sheep
NP_744706  448 HHVFHSEHNRLVQQTkdtllaagdlaflnewliddvtaipttpadiaalvwdgeRLFQAAKFGTEMQYQHLVFEEFARTI 527  Pseudomonas puti...
O82031     279 QALFVQEHNSVCDALkkeyp-----------------------------eleeeDLYRHARLVTSAVIAKVHTIDWTVEL 329  common tobacco
Q9UUS2     287 GGRFKRPTTPDDTAGwet---------------------------------ydnSLFQTGRLITCGLYINIVLGDYVRTI 333  Gaeumannomyces g...
YP_783237  193 HLAFLKFHNKVAQRLiaegk------------------------------vpanKIFTEARQIVTWHYQWLVLHDFVERI 242  Rhodopseudomonas...
EEH35462   359 HTLLLREHNRLCDLLakqhpeyvd---------------------mknsehtdeKLYQTVRLLMSAKYALVANSYQMAYW 417  Paracoccidioides...
EEH44179   323 HTLLLREHNRLCDLLakqhpayvd---------------------mknsehtdeKLYQTVRLIMSAKYALVANSYQMAYW 381  Paracoccidioides...
EEN62449   275 GILWFRWHNYLADRIhaqfp-----------------------------dwhdeRVFNEARKWVIATHQLLANITAFAAE 325  Florida lancelet
Feature 1                                                              #  ###   #  #           
1MYP_C     189 LGptamrkylptyr----------------------------syndsvdpriaNVFTNAFRYg--HTLIQPFMFRldnry 238  human
2E9E_A     317 LGsemqkwippyq-----------------------------gynnsvdprisNVFTFAFRFg--HMEVPSTVSRldeny 365  goat
1PTH_A     329 SGyflqlkfdpell---------------------------fgaqfqyrnriaMEFNQLYHW---HPLMPDSFRVgp--- 375  sheep
NP_744706  528 QPqideflapngy------------------------------dtsinpailaEFAHVVYRFg--HSMLTETVDRydpaf 575  Pseudomonas puti...
O82031     330 LKtdtllagmranwygllgkkfkdtfghvggsilggfvgmkkpenygvpysltEEFTSVYRM---HQLLPDKLQLrnida 406  common tobacco
Q9UUS2     334 LNlnranttwnldprtkeg-----------------ksllskptpeavgnqvsVEFNLIYRW---HCTISERDDKwttna 393  Gaeumannomyces g...
YP_783237  243 TEkgivarilqqgrr--------------------------fyrfkkfpympiEFSAAAYRLg--HSMVRQGYSHnrift 294  Rhodopseudomonas...
EEH35462   418 TDkmpwprddgfplyrqmygesfme------inpmntypwplvtkggkpmvvsAEMAIVYRF---HEFIISQFPIkdakn 488  Paracoccidioides...
EEH44179   382 TDkmpwprdddpk------------------------------vtvkvpstfeEFTSDPEKVqklKTLYDRPDDVdlvvg 431  Paracoccidioides...
EEN62449   326 NDwttdkcdiwvcgllett------------------ergpgplfreiikdqfERIRDGDRFw-fENYRQNGLFTedevt 386  Florida lancelet
Feature 1                                           #                                          
1MYP_C     239 q-----------------------pmepnpRVPLSRVFFaswr------------------------------------- 258  human
2E9E_A     366 q-----------------------pwgpeaELPLHTLFFntwr------------------------------------- 385  goat
1PTH_A     376 -----------------------------qDYSYEQFLFntsm------------------------------------- 389  sheep
NP_744706  576 npvs------------------adpanpdqQLGLIAAFLnplafag---------------------------------- 603  Pseudomonas puti...
O82031     407 tpgp------------------nkslpltnEIPLEDLIGgkgek------------------------------------ 432  common tobacco
Q9UUS2     394 mrealggqdpatakmedvmralgmfeknipDEPEKRTLAgltrqsdgaf------------------------------d 443  Gaeumannomyces g...
YP_783237  295 g------------------------ggdggAATLKQFFTftglsgiiagalapkvpghlpafpsnwiidwrryfevldan 350  Rhodopseudomonas...
EEH35462   489 --------------------------ntlwNQSVFDTGFnpqg------------------------------------- 505  Paracoccidioides...
EEH44179   432 vqldety------------fpgttvpksalIISLFSLFGm---------------------------------------- 459  Paracoccidioides...
EEN62449   387 qiwnltl------------yevissitnitDMDMQENVFlatdspcf--------------------------------- 421  Florida lancelet
Feature 1                                                                 #  #   #             
1MYP_C     259 -----vvleGGIDPILRGLMATpaklnrqnqiavde--------irerlfeqvmriglDLPALNMQRSRDHG-LPGYNAW 324  human
2E9E_A     386 -----iikdGGIDPLVRGLLAKnsklmnqnkmvtsel-------rnklfqpthkvhgfDLAAINLQRCRDHG-MPGYNSW 452  goat
1PTH_A     390 ------lvdYGVEALVDAFSRQpagriggg--------------------rnidhhilHVAVDVIKESRVLR-LQPFNEY 442  sheep
NP_744706  604 ---sgatadEAAGAIIRGVTRQvgneidefvte--------------alrnnllglplDLPALNIARGRDTG-IPSLNEA 665  Pseudomonas puti...
O82031     433 -----nlskIGFTKQMVSMGHQacgalelwnypvwmrd-----lipqdvdgtdrpdhiDLAALEIYRDRERS-VARYNEF 501  common tobacco
Q9UUS2     444 dtelvkilqESIEDVAGAFGPNhvpa-----------------------------cmrAIEILGIKQSRTWN-VATLNEF 493  Gaeumannomyces g...
YP_783237  351 pagvprnpsRKLDPFLVPELHTlpg------------------------------gggDLAFRNLRRGVDLG-LPSGQDV 399  Rhodopseudomonas...
EEH35462   506 ------flnTGLESILRGMVGShipnfk-------------------------sgvdeSFRSAGKYRAGPFD-VKPKVTV 553  Paracoccidioides...
EEH44179   460 ---------GNSDRFSIGFAVTrcllvdqpfdchpsnaleellwkphpepglpnmrrlDDFWLNELDFPDHGtNLLWRLV 530  Paracoccidioides...
EEN62449   422 --qpkqlsqFDMEPCTPDRLGDpadfkrqtfdyfsgsew---syalsfgamglfvvgcVLVLVCLAKRRKLEeAKERIEH 496  Florida lancelet
Feature 1                                                                                      
1MYP_C     325 RRFCGLPqpetvgq-------lgtvlrNLKLARKLMEQYg---------------------------------------- 357  human
2E9E_A     453 RGFCGLSqpktlkg-------lqavlkNKVLAKKLLDLYk---------------------------------------- 485  goat
1PTH_A     443 RKRFGMKpytsf----------qeltgEKEMAAELEELYg---------------------------------------- 472  sheep
NP_744706  666 RREFYAAtgdsqlkpymswvdfadhlkHPASLINFIAAYgthssitgatteaakraaavalvlggdgapldrldflngtg 745  Pseudomonas puti...
O82031     502 RRGMLQIpiskw----------edltdDEEVINTLGEVYg---------------------------------------- 531  common tobacco
Q9UUS2     494 RQFIGLTphdsf----------yhmnpDPKICKILAQMYd---------------------------------------- 523  Gaeumannomyces g...
YP_783237  400 AQAMRIKnp----------------ltPEEIAKGPDGAIak--------------------------------------- 424  Rhodopseudomonas...
EEH35462   554 KVPSTFEef----------------tsNPEKVQKLKALYd---------------------------------------- 577  Paracoccidioides...
EEH44179   531 TENTDISclqq------------dplfPADPKTNPALNF----------------------------------------- 557  Paracoccidioides...
EEN62449   497 RRKETMSat----------------rrENGQSTILASEYmgg-------------------------------------- 522  Florida lancelet
Feature 1                                                                                      
1MYP_C     358 --------------------------TPNNIDIWMGGVSEPLKrk------grVGPLLACIIGTQFRKLRDGDRFWWene 405  human
2E9E_A     486 --------------------------TPDNIDIWIGGNAEPMVer------grVGPLLACLLGRQFQQIRDGDRFWWenp 533  goat
1PTH_A     473 --------------------------DIDALEFYPGLLLEKCHpn------siFGESMIEMGAPFSLKGLLGNPICSpey 520  sheep
NP_744706  746 ayanvtlagadgiagtaddiagvtvtGVDAIDFWVGGLAEKKMpfg-----gmLGSSFNFVFETQLEALQNGDRFYYlsr 820  Pseudomonas puti...
O82031     532 -------------------------dDVEELDLMVGMAAEKKIkg------faISETAFFIFLVMASRRLEADRFFTsny 580  common tobacco
Q9UUS2     524 --------------------------SPDAVELYPGIMAEAAKppfspgsglcPPYTTSRAILSDAVSLVRGDRFYTvdy 577  Gaeumannomyces g...
YP_783237  425 ------------------------khDMHKHTPLWYYILKEAEqrgn---gerLGPVGATIIAEVFVGLVHGDHQSYlw- 476  Rhodopseudomonas...
EEH35462   578 --------------------------RPDDVDLVVGVQLDETYfpg-----ttVPKSALIISLFSLFGMGNSDRFSIgfa 626  Paracoccidioides...
EEH44179   558 --------------------------AKDPKGVLLKGFVEYGQtvs-----rcFGLKLASLVYFVVTRSTDLEWMEAdn- 605  Paracoccidioides...
EEN62449   523 ------------------------kdGEHSVQIMLGPGKEVKV----------LDQCLNTVRTIDLKNYARLDIYLAve- 567  Florida lancelet
Feature 1                                                                         
1MYP_C     406 gv--------fsmqqRQALAQI------------------------------------SLPRIICDN 428  human
2E9E_A     534 gv--------ftekqRDSLQKV------------------------------------SFSRLICDN 556  goat
1PTH_A     521 wkas-----tfggevGFNLVKTa-----------------------------------TLKKLVCLN 547  sheep
NP_744706  821 ta---------gmnfGTELENN------------------------------------SFAKLIMAN 842  Pseudomonas putida KT2440
O82031     581 nee------tytkkgLEWVNTTe-----------------------------------SLKDVLDRH 606  common tobacco
Q9UUS2     578 tpr------nitnwgFNEASTDkavdwghviyklffrafpnhflpnsvyahfpfvvpsENKLIFEGL 638  Gaeumannomyces graminis var. ...
YP_783237  477 --------------lKGKDWKPtlpsk--------------------------tpgdfTMADMLRFV 503  Rhodopseudomonas palustris Bi...
EEH35462   627 itrcllvdqpfdchpSNALEELlwkp----------------------------hpepGLPNMRRLD 665  Paracoccidioides brasiliensis...
EEH44179   606 --------------sKEEIFSLhkfl-----------------------------gviNFPLIVHQE 629  Paracoccidioides brasiliensis...
EEN62449   568 --------------rNGNMLAM------------------------------------KIPKEYDLI 584  Florida lancelet

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