1I0Z,1I10,5LDH,1V6A,2LDX,2V65,2I6T


Conserved Protein Domain Family
LDH_1

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cd05293: LDH_1 
Click on image for an interactive view with Cn3D
A subgroup of L-lactate dehydrogenases
L-lactate dehydrogenases (LDH) are tetrameric enzymes catalyzing the last step of glycolysis in which pyruvate is converted to L-lactate. This subgroup is composed of eukaryotic LDHs. Vertebrate LDHs are non-allosteric. This is in contrast to some bacterial LDHs that are activated by an allosteric effector such as fructose-1,6-bisphosphate. LDHs are part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenases, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.
Statistics
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PSSM-Id: 133429
View PSSM: cd05293
Aligned: 28 rows
Threshold Bit Score: 398.901
Threshold Setting Gi: 76779532
Created: 14-Dec-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:NAD binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                   ###                    # #   #                                     ##
1I0Z_A        18 VPNNKITVVGVGQVGMACAISILGksLADELALVDVLEd-KLKGEMMDLQHGSlflqTPKIVADKDYSVTANSKIVVVTA 96  human
2I6T_A        12 KTVNKITVVGGGELGIACTLAISAkgIADRLVLLDLSE--GTKGATMDLEIFN----LPNVEISKDLSASAHSKVVIFTV 85  human
AAI06380     136 PSHAKVTVIGGGDMALACLLAVSAkgTAGKLVLLDPTDgePAGGATADLEIFS----LPNVQVTKDFSAIAGSAIVIVTV 211 African clawed ...
NP_610888     46 PRISKISVVGAGQVGTAISAMLLLrnLTKNLVILDINYe-LAKAEALDFQHASaflsDARVVPCGDSTNSKDSDVVIITA 124 fruit fly
XP_002049530 388 QPGNKVSVIGAGAVGMGCAIALLAkgITNNIALYDLKKd-LCAAECMDLEHGSlflnNCNIDHCTSVECTKDSRVVVVTA 466 Drosophila virilis
XP_002138786  40 KPSLKITVVGSGQVGAAVAAFLLArnLTKHLVILDVKYd-LATAEALDFSHGSaflgNPIVEACGDGNRTKNSDVIIITA 118 Drosophila pseu...
XP_001961105  56 KPGFKITVVGAGQVGLACCAFLLQrrLAKELVIMDIQYe-RAQAEARDFNHAAvfltDPKITACGDGVNTKDSDVVIVTA 134 Drosophila anan...
XP_002064001  38 KISPKISVVGAGQVGISICAFLIQrnLARHLVIHDIRYd-WAKAEALDLLHAScwlkNPHIEACGDGSHTKDSDIVIVTA 116 Drosophila will...
XP_421014    233 GCFNKVTVVGAGDLGIACVLAVVAkgIADKVVLLDLSEg-AAKGGAMDLEIFA----LPNVEISKDFSASTDSKVVVLTV 307 chicken
XP_002052761  17 EPADKISVIGTGQVGLSCCAFLIDrrLANHLVMVDLRQe-WVKAEALDFLHVSsllaSPKIETCTDASCTAGSKYVIITV 95  Drosophila virilis
Feature 1        ###                                     # #                      #   #          
1I0Z_A        97 GVRQQEGESRl-NLVQRNVNVFKFIIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGlpkHRVIGSGCNLDSARFRYLMA 175 human
2I6T_A        86 NSLGSSQSYL--DVVQSNVDMFRALVPALGHYSQHSVLLVASQPVEIMTYVTWKLSTfpaNRVIGIGCNLDSQRLQYIIT 163 human
AAI06380     212 NAWSNSQSYV--GVLQSNVELLRRIVPTVVHHCPKCLLLVASQPVEIMTYVTWKLSGfphTRVLGIGCNLDSGRFHHVIE 289 African clawed ...
NP_610888    125 GARPSGKDRSrlAAMQKTVEILKKAVPKLVELSPNATFIIISNPADVMTYAVQRITNlpkHRCFTTGCHLDTVRFRNLIA 204 fruit fly
XP_002049530 467 GVRCNQNESRl-KVAQKSAGIIKEIVPELVKQSPKGVFIIVSNPADVMAWVARKVTKlpyERCFSPGCHLDTARFRMFIA 545 Drosophila virilis
XP_002138786 119 GARPSGKTRSrlDVMHKTVVILKSVVPKLVELSPKAIFIIICNPADVMTFAVQRIGNlekHRCFTTGCHLDTARFRYLIA 198 Drosophila pseu...
XP_001961105 135 GVRPGKKSRL--EVMHDTIKIFKELVPKLVSFSPNAIYLVVSNPADVMTHAFQKIGKipkHRCFSTGCHLDTARFRYFIA 212 Drosophila anan...
XP_002064001 117 GARPVGKDRSrlLVMKKTVEILKLAMPKLIELSPKAVFVIVSNPADVMTYAIQRICKlekHRCFTTGCSLDSARFRFLIA 196 Drosophila will...
XP_421014    308 NSLGNAQTYL--DVIQSNVDLFRGIIPAISHYSQNSVLLVASQPVEIMTYVSWKLSAfpkSKVIGVGGNLDTERFQYILT 385 chicken
XP_002052761  96 GTRPAGKSRL--DIAKESLELLSKLVPKLVESSPDATYVISSNPADVMTWAVRKMSGlpkERCISCGCHLDSLRFRYFLA 173 Drosophila virilis
Feature 1                         #                                                      #   #   
1I0Z_A       176 EKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVslqelnpemgtdndsenwKEVHKMVVESAYEVIKLKGYTNWAIGLS 255 human
2I6T_A       164 NVLKAQTSGKEVWVIGEQGEDKVLTWSGQEEVVS------------------HTSQVQLSNRAMELLRVKGQRSWSVGLS 225 human
AAI06380     290 KLVNSEEGAQDAWIIGEQSENKVAVWGDPDSSAKnqisg---------klypKIFQEQLTSRALEMLKGKGQRSWSVGLS 360 African clawed ...
NP_610888    205 NRLRLPPSQVHGYVIGEHGASAVPVWSSVSIAGIrlndvvknlacgddpenwAKINKQVTTGGLAVAKTKGYTNWAIALT 284 fruit fly
XP_002049530 546 QLVRVSTRSVHGFVLGEHGDSSVPLWSSVTVGGTrlqnmlptigtdkdpmrwSNVHESVVDSAFKVIAGKGYTNWAIGLT 625 Drosophila virilis
XP_002138786 199 KRLKVPTSAVNAYIIGEHGSSAVPVWSSVTVGGIrlsdvvkdlgtdkdqekwSDLMDGILNAGVHVSKAKGYTNWAVGLT 278 Drosophila pseu...
XP_001961105 213 QRLKVPTTAVKGFVIGEHGDSAVPVWSGVQVAGAclkdivknpgcgpdpekwAEINKEVTCGGSSVSSVKGYTNWAVALT 292 Drosophila anan...
XP_002064001 197 QRLKVPTTEVEGYVIGEHGNSAVPVWSSVTVGGVplvkvvrdlgtsmdtenwNNLFKDVTQAGASVGNIKGYTNWAIALS 276 Drosophila will...
XP_421014    386 KLLQAEALGKDAWIVGEQGEDKVPSWTSSKSVTNetet-----------taaHNSREKVANRAVEVLKGKGQRSWSVGLS 454 chicken
XP_002052761 174 QRLGVAASEVNAFIVGEHGDSSVPVWSGVTVGGIallrllpnigrdqdeekwQKVHEDVVKAGSSVSKIKGYTNWGVALA 253 Drosophila virilis
Feature 1                                                                                    
1I0Z_A       256 VADLIESMLKNLSRIHPVSTMVKgmygieNEVFLSLPCILNARGLTsVINQKLKd--DEVAQLKKSADTLWDIQKD 329 human
2I6T_A       226 VADMVDSIVNNKKKVHSVSALAKgyydinSEVFLSLPCILGTNGVSeVIKTTLKe-dTVTEKLQSSASSIHSLQQQ 300 human
AAI06380     361 VADITHTLILNNGKVHSVSTLSKglfgvqEEVFLSIPCVLGSVGVM-GTVQTLQedvQIWETLQRSAAAIEAVQQQ 435 African clawed frog
NP_610888    285 CADIVQAMSGGKGKIACVGTDMKglngiqDNVVLSLPCLVTAGGIShVFELPLTd--VEQSKLLASANILLEAQCS 358 fruit fly
XP_002049530 626 VTDVVSAIFENSNRIMSLSTNAQgmcgidDEVFLSLPCIVNQCGLYgVIHPQLSg--WEERRLKRSADVLLDAQKT 699 Drosophila virilis
XP_002138786 279 ASDVVKCMVENTGQVCCVGTDVKglyglkDSVVLSVPCRVTASGIShILELPLNe--DERKKLLKSADTLLEAQCS 352 Drosophila pseudoob...
XP_001961105 293 AVDVVAAIAGPYGRIMSIGTDMKgihdieENVVLSMPCMVTPSGIShIFEIPLSh--GEFEMLHKSAKILFKAQCE 366 Drosophila ananassae
XP_002064001 277 AVNVVEAMLENSGRILCLGTDMQgmnsigQQVVLSLPCKVTSTGIShVLQLPLTa--LEQEKLHKSAEVLMKAQCS 350 Drosophila willistoni
XP_421014    455 VADLTDSILKDKRKVHSVSTLAKgfcninSEVFLSLPCILGTSGVVeTLTLEEDp--AVQEKLQSSAGSIHDLQQQ 528 chicken
XP_002052761 254 IVDIIQAMMTNSGRILSVGSDIQglmgvnDSVVMSLPCILGTHGVQkVIELPLTe--FEMNMFEKSKEVLMKAQCA 327 Drosophila virilis

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