Conserved Protein Domain Family
LDH_3

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cd05290: LDH_3 
A subgroup of L-lactate dehydrogenases
L-lactate dehydrogenases (LDH) are tetrameric enzymes catalyzing the last step of glycolysis in which pyruvate is converted to L-lactate. This subgroup is composed of some bacterial LDHs from firmicutes, gammaproteobacteria, and actinobacteria. Vertebrate LDHs are non-allosteric, but some bacterial LDHs are activated by an allosteric effector such as fructose-1,6-bisphosphate. LDHs are part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenase, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.
Statistics
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PSSM-Id: 133426
View PSSM: cd05290
Aligned: 9 rows
Threshold Bit Score: 452.554
Threshold Setting Gi: 72494073
Created: 28-Aug-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:NAD binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              ###                    # #                                          #####
Q9EVR0        6 KIVVIGASNVGSAVANKIADFQLATEVVLIDLNeDKAWGEAKDSSHATsciystNIKFHLGD-YEDCKDANIIVITAGPS 84  Selenomonas rumi...
NP_799657     2 KIGVIGAGAVGVGVCNYLLTLGSVSELVLLDQNlERAEGEVFDFRHTAaltfskNTRIIPSDdYLDLLGADIVVITAGAQ 81  Vibrio parahaemo...
YP_054733     6 HLVVIGIGHVGSDVVTNAAALGLFSRISLIDVDkKVRDGQALDNHQATavapamTTTITAAN-YDACRSADVIIVSAGPS 84  Propionibacteriu...
NP_938808     3 KLVVIGLGHVGSYVLSYAMASGLYAEIATIDTNpGVALGEAIDLAQATgvpgttNTYCHEGT-YADCADADVIICAAGES 81  Corynebacterium ...
BAE17394      3 KLGIIGLGKVGTQVLTDVQQLNLFSEIILIDDRaDVASGEALDHIHSQglintaHIKIRSGV-YQDLTDADFIVIAASEA 81  Staphylococcus s...
YP_056628     7 KLGIIGVGRVGDAVLSDAMMSGLFGEICVIDVNeKLAAGQALDQHHATalpnvtNVAVYAGD-YDDLSNADVIIMTAGPS 85  Propionibacteriu...
Q97DC6        7 KLVVVGAGMVGSAVLNSVLSLNLLSEVVIIDINdNKAKGEALDASHTTsfayspNVKVRAGN-YEDCADAQIIVITAGPS 85  Clostridium acet...
ZP_01697640   5 KLVVAGVGHVGSYVLANAMKLGLFSEIAVLDKKkGVAFGEALDWRHATaltympNTSVKAGD-YSECADADVIICAAGPS 83  Bacillus coagula...
ZP_01113426   2 KIGVIGAGAVGVGVCHYTLAFGSCSELVLIDQQiGKAEGEMMDFGHANsltfskNIRLRAGDdYSLLTDADIVVITAGAQ 81  Reinekea sp. MED297
Feature 1                                                    # #                      #   #     
Q9EVR0       85 IRPGETPd-----rLKLAGTNAKIMSSVMGEIVKrt--kEAMIIMITNPLDVATYVVSTqfDYPRNLILGTGTMLETYRF 157 Selenomonas rumi...
NP_799657    82 IQQGQTR-------LDIAEINAKIGVEIARKIERva--pKAVLIVVSNPCDIVAHFITTntGFEPNKVISSGCVIDTARL 152 Vibrio parahaemo...
YP_054733    85 VLPDSYGggh-dsrNSLAQVNSKVIREVMGNICQyt--hSAPIILITNPLDVNVHIAATefDYPTNLVVGTGTALDSARL 161 Propionibacteriu...
NP_938808    82 IVPDPNDptrmpdrSELAQISGAVIRDVMTNITAnvgenPPVLILITNPLDAMVHIAAT--EFGYPKVFGTGTMLDSARL 159 Corynebacterium ...
BAE17394     82 TDKNNGDr------TLLAQGNHDIIKGIMSQIAEvt--qEAVVILISNPVDSMVYFANQi-DYPAHKIIGTGTALETSRF 152 Staphylococcus s...
YP_056628    86 IDASNGPatg-aarRELAATNGKIIRSTMTQITSrn--hDAAIIICSNPLDALVHIASTefDHPQGLVLGTGTILDSARM 162 Propionibacteriu...
Q97DC6       86 LKPDDKLd-----rLVLADTNVKVTDSIMKNICKyt--kDAIIIVVTNPVDIATYYCQNnfDYPKNKIIGTGTLLDTARM 158 Clostridium acet...
ZP_01697640  84 VLPSEKDemp--drAGLARTNAAVVREVMAGITKyt--kEAVIIFITNPLDTIVYIAENefGYSKGRIFGTGTMLDSARL 159 Bacillus coagula...
ZP_01113426  82 IKEGQTR-------DDLAEINSRITVDIAQKIETva--pNAILLVVTNPCDIATYFITQntGFPADRVISAGCIIDTARL 152 Reinekea sp. MED297
Feature 1                             #                                                     #   
Q9EVR0      158 RRILADKYQVDPKNINGYVLGEHGNAAFVAWSTTGCAGFPiddldeyfhrteklshEAVEQELVQVAYDVINkKGFTNTG 237 Selenomonas rumi...
NP_799657   153 MSIVANRVDLDPKNIFGYVLGEHGSHCFTPKSLISIAGQPadyycdth-nieridaDELLEAVKQAGYEIFRrKHNTVHG 231 Vibrio parahaemo...
YP_054733   162 RRHLADWAGVSPDSVQAFMLGEHGATAFPYLSHASIGGLTlaeattal-glqplspDQVGNSVVQSAFDILEgKGWTSSG 240 Propionibacteriu...
NP_938808   160 RYIIGTELGIDPKSVTGYMMGEHGSTSVPILSQVNVQGLRweeleawh-gkplptaPEMQEKVVRAAYDVLLsKGWTNAG 238 Corynebacterium ...
BAE17394    153 KTIIADHYQIDPNNVEAFVIGEHGQHAIPVWSKVHIHGMElsefeals-drpaidkSHISSIINEVSMDVFYqKGWTNAA 231 Staphylococcus s...
YP_056628   163 CRVVADHLGVDPDYVRGYMIGEHGPSGFPMFTGVNVGGVGfdglaklf-dadpmdrDELTTRINDAGTAVFNlKGWTSAG 241 Propionibacteriu...
Q97DC6      159 RKIIGKKYNVDSKNVHGYVLGEHGGSSFTSWSDVNIAGIPfnqlndifkdhykvdkDEVDKEVRDSGIEVLKlKGYTSAG 238 Clostridium acet...
ZP_01697640 160 RQLVAENYSIDPKSVTGYMMGEHGFTAFPVFSRLNVQGFRekeldsvfkgkepldrEAFRQKVVKTAFDVLNgKGWTNAG 239 Bacillus coagula...
ZP_01113426 153 MKLVSEKVDVDPKNVSGYILGEHGSHCFMPWGLVGVAGQPidyycqhn-gfdaidpQTLLEEVKQAGFEIFKrKHNTTHG 231 Reinekea sp. MED297
Feature 1       #                                                                            
Q9EVR0      238 IAMAACRFIKSVLYDEHTILPCSAVLEGeyg-ikDVALSIPRMVCADGIMRSFEVHLTDDELEKMHKAAQSVRSALD 313 Selenomonas ruminan...
NP_799657   232 IAASVFRIIQAIKINERSVLPVGTMMSGqyg-vsGVVLSLPTVVGKKGAESVLTHPFTEEELETLHSISMNLRSIVE 307 Vibrio parahaemolyt...
YP_054733   241 ISKAAVSLARAMLLDQRSIHPVCTLADGvlgfhsEVSLSLPTVVSGHGVEHHLNIVLDEWEQEKLLVSAKAVREVYE 317 Propionibacterium a...
NP_938808   239 VARSANELAKCVLLNERAVHPICTPLHGeyg-leDVSLSIPTEITHEGAGRKMLPQLNEWELEQLHKSAEFIRETVR 314 Corynebacterium dip...
BAE17394    232 ISKVTSFLIQSIALDQRTITPLTSLSSEyg--leDGAFSLPTLIDKKGIVQRFAITLDKEEERELKEAYEYIRQTIH 306 Staphylococcus sapr...
YP_056628   242 IGQSAITIARSILLNEHAVYPVCTTLHGqyghdgDVSMGVPCVIGATGVERILEVPLDDWEQEHLASTIKAIQETVE 318 Propionibacterium a...
Q97DC6      239 IAMSVSRLVKAMLLNEQSILPVSSTLEGeyg-inDVALSIPCIITSNGIEKKLEIPLSKDEVEKLNKSADNLKSIIK 314 Clostridium acetobu...
ZP_01697640 240 VAEAAVTLAKAVMLDEKSIYPVSATLHGqygyngDVALSIPSVIGRNGIEQQLEIELDEQETSWLHESAKSIQNTMA 316 Bacillus coagulans ...
ZP_01113426 232 IAASVFRMIQAITIDEYSILPVGTLLSGhyg-lsDVVLSLPTIVNARGAHKVLEHPFSETETRELHDIAAALQKLIR 307 Reinekea sp. MED297

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