1PL6,1E3J


Conserved Protein Domain Family
sorbitol_DH

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cd05285: sorbitol_DH 
Click on image for an interactive view with Cn3D
Sorbitol dehydrogenase
Sorbitol and aldose reductase are NAD(+) binding proteins of the polyol pathway, which interconverts glucose and fructose. Sorbitol dehydrogenase is tetrameric and has a single catalytic zinc per subunit. Aldose reductase catalyzes the NADP(H)-dependent conversion of glucose to sorbital, and SDH uses NAD(H) in the conversion of sorbitol to fructose. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. The medium chain alcohol dehydrogenase family (MDR) have a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit.
Statistics
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PSSM-Id: 176188
View PSSM: cd05285
Aligned: 93 rows
Threshold Bit Score: 362.967
Threshold Setting Gi: 116194514
Created: 27-Jul-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:NADP binding site [chemical binding site]
Evidence:
  • Structure:1PL6: Human sorbitol dehydrogenase binds NAD, contacts at 4A
    View structure with Cn3D
  • Comment:NADH is cofactor in coversion of sorbitol to fructose

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
1PL6_D        10 SLVVHGp-gDLRLENYP--IPEPgpNEVLLRxHSVGICGSDVHYWEYGRIGNFIvkkPXVLGHEASGTVEKVGs---sVK 83  human
CAP93967       8 ALVLHGa-kDLRLEQRT--IPAPstTEVQVAiRATGLCGSDLHYYSHGRNGDFVvraPMCLGHESAGTVTATGs---aVT 81  Penicillium chr...
XP_756559     47 SAVLHGa-kDLRIEERPyaAPIG--DEVQIRvRATGLCGSDLHYYLHGRNGDFAlqhSMCLGHESAGEIVAVGpnvpaSL 123 Ustilago maydis...
XP_001223069  25 ASVLHGp-rDLRMERRT--IGDPsiGELQIAvHTTGICGSDVSYYKKFANGDLCacmPLSLGHESSGTVVAIGp---qVV 98  Chaetomium glob...
XP_001405648   6 ASVLYGp-kDLRVEERT--IPAPaaGEVQVSiRATGICGSDMHYYVHGANGDFKvrePLSLGHESAGVVEAVGp---dVT 79  Magnaporthe gri...
XP_001548542  17 ASVLHGa-kDLKVETRAlgVPEP--KEVQVAvQATGLCGSDLHYYNHYRNGDIIvrePMTLGHESAGVVTAVGs---eVS 90  Botryotinia fuc...
XP_001881011  11 AAVLHGp-rDLRIEDRTlwPPAP--TQVQVAvASTGLCGSDLHYYMHGRNGDFAvraPLVLGHEAAGVVTAIGa---gVN 84  Laccaria bicolo...
XP_001243751  10 ALVLHGp-eDLRLETRE--TPYPaaGEVQIAiRATGLCGSDLHYFYQGRNGDFVvraPLCLGHESAGTVTALGa---dVT 83  Coccidioides im...
XP_001542152   2 SSPNPQhfrALVLHGAKd-LRLS--GELQIAiRVTGLCGSDLHYYQHGRNGDFImraPLCLGHESAGTITAVGt---dVE 75  Ajellomyces cap...
XP_001803987  25 ASVLHGp-rDLRLETRPitDPGP--NELQIAiKATGLCGSDCSYYSKFRNGDLHacqPLSLGHESAGVVVAIGe---sVS 98  Phaeosphaeria n...
Feature 1                                                                                        
1PL6_D        84 HLKPGDRVAIEPGAPRENDEFCKxGRYNLSPSiFFCATPPd----DGNLCRFYKHNAAFCYKLPDNVTf----------- 148 human
CAP93967      82 TLKVGDRVALEVGLPCRTCALCKqGRYNICKAmQFRSSAKvfphlDGTLMERTNHPADMCHPLPDSVSd----------- 150 Penicillium chr...
XP_756559    124 GLAVGDRVAIEAGRFCGSCLKCRdGRYNLCKQmRFASSAKthphlDGTLQKYMNWPSWLVHKLPANVSl----------- 192 Ustilago maydis...
XP_001223069  99 GFNIGDRVALEVGIPCGQCGICRrGRYNLCKRmRFRSSAKsvphfQGTLQERINHPAAWCHNHSRLPStpstgrnpprvr 178 Chaetomium glob...
XP_001405648  80 DLKVGDRVAVEVGIACDDCALCKsGRYNLCKGmKFRSSAKifphfQGTLQDRINHPARLTYKLPDSASl----------- 148 Magnaporthe gri...
XP_001548542  91 NLKVGDHVALEVGLPCKSCDLCVnGRYNICKEmKFRSSAKafphfQGTLQERINHPAAYCHLLPENVSl----------- 159 Botryotinia fuc...
XP_001881011  85 NFTVGQRVAIEAGVFCRTCSYCEkGRYNLCKSmRFCSSAAvyphaDGTLQTRMNHPAYVLHHLPDSCTf----------- 153 Laccaria bicolo...
XP_001243751  84 TLQAGDRVALEVGIPCRKCTLCLqDRYNLCSSmRFRSSAAvfphlDGTLMDITNHPAMLCHKLPPTISd----------- 152 Coccidioides im...
XP_001542152  76 DFQVGDRVALEVGFPCTSCGLCIeGRYNICRSlRFRSSAKtfphlDGTLMELTNHPFDKCHKLPAHISd----------- 144 Ajellomyces cap...
XP_001803987  99 GFQIGERVALEVGVPCDNCRSCQrGRYNLCPKmRFRSSAKsvphfQGTLQERINHPAKWCHKLPAHVSm----------- 167 Phaeosphaeria n...
Feature 1                    #                                    ###                   ###   #  
1PL6_D       149 --EEGALIEPLSVGIHACRRggv---------------tlGHKVLVCGAGPIGXVTLLVAKAXGAAq-VVVTDLsATRLS 210 human
CAP93967     151 --AGGALVEPLAVTLHAVRRshppskeev---amnraageETPALVFGAGAIGLLLAGALAASENFsqIVVADIdARRLK 225 Penicillium chr...
XP_756559    193 --TSAALCEPLSVVLQGIRRsql---------------qpGQSVLVYGAGAVGLLACAAAKASGASf-VAAVDIdQGRLA 254 Ustilago maydis...
XP_001223069 179 prSSSAPAPLASSPPPWARQs-------------------GCTTVTIADVDQGRVDFAVAKGFATH--GYVVDR-PLHTS 236 Chaetomium glob...
XP_001405648 149 --AEGALLEPLGVAIHGVKRage---------------qkGKTALVLGAGAVGLLTAAVLRVEGIEs-IAIADIvPERVQ 210 Magnaporthe gri...
XP_001548542 160 --ELGAVLEPLSVAIHGTRRaal---------------pkGKTVLIFGAGAVGLLCAAMCRVTGAKn-IVIADIqPDRLD 221 Botryotinia fuc...
XP_001881011 154 --EQAALAEPLSVLIHATRRanl---------------taGQTVLVFGVGAIGLLACAVAKSMGASr-IVAIDInQPRLD 215 Laccaria bicolo...
XP_001243751 153 --VQAALIEPLAVCIHAVNRskldisa------iaqipqrDVTALIFGAGAIGLLLACVLAASQPFtaIVVADInTKRLQ 224 Coccidioides im...
XP_001542152 145 --VQSALIEPLAVCMHAIRRsnppdaesvaralsatrvpeETAALIFGAGAIGMLLTAALAATQHFstLVVADIdEARLR 222 Ajellomyces cap...
XP_001803987 168 --ESAALLEPLSVAIHATRRahi---------------eqGDTAIVFGAGAVGLLTAAMAKVSGATt-VVIADIdYGRIN 229 Phaeosphaeria n...
Feature 1                                  #                                                     
1PL6_D       211 KAKEi--------------GADLVLQIskespqe-------------------iarkveGQLGCk--------------- 242 human
CAP93967     226 IAEEmg------------iGLKTALIPraetpppakdaphaeqtayalenaqkvaaalvEAVGArdglv----------- 282 Penicillium chr...
XP_756559    255 FAAAngwada---tyllprAAPAAVDGeqtnvgarraaedk----aaissasasaasllKALSSsdpsssqqtsyaiqpa 327 Ustilago maydis...
XP_001223069 237 TNSSpmys-------psssGTSTPLNGvmtpasalsmqsq-------fdyakslaadmlSLTSAassptftgln-----d 297 Chaetomium glob...
XP_001405648 211 FAVAh-------------gFADKAVVVpskrlppta--------------sadeklalaRETAAlltreg---------- 253 Magnaporthe gri...
XP_001548542 222 FAVQnn-----------faNAKLLVPMtrpqtiedk---------------lafakevaELVKEasge------------ 263 Botryotinia fuc...
XP_001881011 216 FAKDn-------------gFASQVFCLpmadkak------------------tsdeqlrRAKETaqlalst--------- 255 Laccaria bicolo...
XP_001243751 225 IASTlpytnit-phhllakQAPSSCTPeadddy---------------------aksiaAELAAkftl------------ 270 Coccidioides im...
XP_001542152 223 IAASlpfplekirtyllpkPASEATPQaeaea-----------------------dlaqQILSAfclp------------ 267 Ajellomyces cap...
XP_001803987 230 YALAngfahkg-yivtpqrEATETAEKldq---------------------------akELATDimqiasln-------- 273 Phaeosphaeria n...
Feature 1                      ## #                   ###                      ###               
1PL6_D       243 --------pEVTIECTGAEaSIQAGIYATRsGGTLVLVGLGsex-ttVPLLHAaiREVDIKGVFRYc-NTWPVAISXLAS 312 human
CAP93967     283 -----vngfSRVYDCTGVPaCVQAGIYASApGGVLVQIGMGnpi-qtLPVGAAalREVDIIGVFRYdgHAYPAAIALLAS 356 Penicillium chr...
XP_756559    328 pldlssegfDVVFECTGVPtCVQTGIFATKaGGKVVLIGMGnpi-qtLPVGSAslREVDIVGVFRYa-NTYPVALGLLAG 405 Ustilago maydis...
XP_001223069 298 nndddddgvDITFECTGKEvCMHTSLYATRaGGRVIMVGMGtpv-qtLPMSVAhlREIDILGIFRYa-NTYATGIRLLCA 375 Chaetomium glob...
XP_001405648 254 ---nggdeyDTTFECTGVEsCVQAAIYATGpGGRVMMIGMGtpv-qtLPLGAAalREVDLLGVFRYa-NTYPRGIELLAG 328 Magnaporthe gri...
XP_001548542 264 ------gevDAVFECTGVEsCLQASIYATKpGGKIMLIGMGtpi-qtLPISAAalREVDLVGVFRYa-NTYADAIKLVAS 335 Botryotinia fuc...
XP_001881011 256 --feakdgfDVVFECTGAEpAIQTSVHAAIaGGKVMLIGMGsrn-vmLPLSSAalREVDIQGSFRYa-NTYPAALELLSS 331 Laccaria bicolo...
XP_001243751 271 -----phgfTRVYDCTGSPsCIRAAIHASSpGGAVVLVGMGgprlptLPLSFAalREIDLIGVLRYdgRCYPEAVRLMAS 345 Coccidioides im...
XP_001542152 268 ------ngfSRTYDCTGVAsCIRMGIYATGpGGAVVQIGMGgaaqpnIPLSAAalREVDLIGVFRYatRGYPDAVALMGS 341 Ajellomyces cap...
XP_001803987 274 --dpefegaDVTFDCTGKEiCMQAGLYATRpGGQLVMVGMGtpi-qtLPMSAShlKEVDIIGIFRYa-NTYPTGIKLISA 349 Phaeosphaeria n...
Feature 1                                                                                     
1PL6_D       313 k-------------------------------sVNVKPLVTHRFPL--EKALEAFETFkkg-------lgLKIXLKC 349 human
CAP93967     357 gk-----------------------------mkSVEEKVVTHRLKL--EEGERAFTLAgkgvde-egnpvVKVIIES 401 Penicillium chryso...
XP_756559    406 gtlraqggglhaqavglptnldtneghgpgrkmGGIENLVSHTFPL--KHAIKAFETLangkdpehgrgvVKVFITD 480 Ustilago maydis 521
XP_001223069 376 rerqvqag-----------------avgsglilPCLDEMVTHRFKGl-ENAHRAFELAsrtvdd-egnlvLKVVIET 433 Chaetomium globosu...
XP_001405648 329 res---------------------------ngmPDIGLLATQNVKGl-DRAEDAFAIAakpvda-dgklvLKVIIET 376 Magnaporthe grisea...
XP_001548542 336 kdp----------------------------llPDLSKLITQRYKGf-QNIPEAFAMAgkvkde-ngnlvLKVLVDT 382 Botryotinia fuckel...
XP_001881011 332 gk------------------------------lENVEKLITHRFPL--EDTKSAFELLargkde-dgkmvLKVMIES 375 Laccaria bicolor S...
XP_001243751 346 gk-----------------------------ldGVTERIVTHTVEFgnEGGQKAFRLAgngvdd-egntvVKVVVMG 392 Coccidioides immit...
XP_001542152 342 ek-----------------------------fqGVAEKVATHFVRF--EEGDRAFELAakgvde-qgkpvVKVIVVS 386 Ajellomyces capsul...
XP_001803987 350 gv------------------------------lPNLDNMITHRYHGl-ASVKEAFELAgktldn-dgnlvLKVLVEM 394 Phaeosphaeria nodo...

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