1LEH,1B26,1C1X,1EE9,1HRD,1QR6,1VL6,1DIA,1GPJ,1LUA,1NPD,1LLQ


Conserved Protein Domain Family
NAD_bind_amino_acid_DH
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cd05191: NAD_bind_amino_acid_DH 
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NAD(P) binding domain of amino acid dehydrogenase-like proteins
Amino acid dehydrogenase(DH)-like NAD(P)-binding domains are members of the Rossmann fold superfamily and are found in glutamate, leucine, and phenylalanine DHs (DHs), methylene tetrahydrofolate DH, methylene-tetrahydromethanopterin DH, methylene-tetrahydropholate DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.
Links
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Statistics
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PSSM-Id: 133449
Aligned: 14 rows
Threshold Bit Score: 38.5125
Created: 1-Jun-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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NAD(P) binding
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:NAD(P) binding pocket [chemical binding site]
Evidence:
  • Structure:1QR6_A: human Mt malic enzyme binds NAD, contacts determined at 3.5A
  • Structure:1NPD_A: E. coli shikimate DH binds NAD, contacts determined at 3.5 A
  • Structure:1LUA_A: Methylobacterium extorquens M-THM DH binds NADP, contacts determined at 3.5A
  • Citation:PMID 9765566
  • Structure:1CIX_B: Rhodococcus Phe DH binds NAD, contacts determined at 3.5A
  • Structure:1DIA_A: human bifunctional methylenetetrahydrofolate dehydrogenase cyclohydrolase bound to NADP, contacts determined at 3.5A
  • Citation:PMID 9519408
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                       ###                             ##            
1LEH_B    149 VTAYGVYRGMKAAakeafgsdsleGLAVSVQGL-GNVAKALCKKLNte-----------gaKLVVTDVnkaavsaavaee 216 Bacillus sphaericus
1B26_F    188 ATGRGVKVCAGLAmdvlg--idpkKATVAVQGF-GNVGQFAALLISqel---------gskVVAVSDSrggiynpegfdv 255 Thermotoga maritima
1C1X_B    152 TTAVGVFEAMKATvahrg-lgsldGLTVLVQGL-GAVGGSLASLAAea-----------gaQLLVADTdtervahavalg 218 Rhodococcus sp.
1HRD_A    208 ATGYGSVYYVEAVmkhen--dtlvGKTVALAGF-GNVAWGAAKKLAelg----------akAVTLSGPdgyiydpegitt 274 Clostridium symbiosum
1QR6_A    282 GTAAVALAGLLAAqkvis--kpisEHKILFLGA-GEAALGIANLIVxsxvenglseqeaqkKIWXFDKygllvkgrkaki 358 human
AAN70008  118 AAGAVAARWLARQd----------SEEVALLGA-GEQAELQLKALLlvr---------dikRVRVWARssakaqqlalql 177 Pseudomonas putida...
AAP07893  113 ALSGVATKYLARHn----------AKTLCIIGT-GEQAKGIAEAIFavr---------dieKVILYNRteekayafaqyi 172 Bacillus cereus AT...
1DIA_A    147 CTPKGCLELIKETgvp------iaGRHAVVVGRsKIVGAPMHDLLLwn-----------naTVTTCHSktahld------ 203 human
1GPJ_A    149 SIGSAAVELAERElgs------lhDKTVLVVGA-GEMGKTVAKSLVdrg----------vrAVLVANRtyeravelardl 211 Methanopyrus kandleri
1NPD_A    106 TDGTGHIRAIKESgfd------ikGKTXVLLGA-GGASTAIGAQGAieg----------lkEIKLFNRrdeffdkalafa 168 Escherichia coli

Feature 1                                                  ##                             # 
1LEH_B    217 ga-------------------------davapnaiygvtcDIFAPCAlgavlndf---------tipqlkakVIAGSA 260 Bacillus sphaericus
1B26_F    256 eelirykkeh--------gtvvtypkgeritneelleldvDILVPAAlegaihag---------naerikakAVVEGA 316 Thermotoga maritima
1C1X_B    219 h--------------------------tavaledvlstpcDVFAPCAmggvitte---------vartldcsVVAGAA 261 Rhodococcus sp.
1HRD_A    275 eekinymlemrasgrnkvqdyadkfgvqffpgekpwgqkvDIIMPCAtqndvdleqa------kkivannvkYYIEVA 346 Clostridium symbiosum
1QR6_A    359 dsyqepft------------hsapesipdtfedavnilkpSTIIGVAgagrlftpdvi----raxasinerpVIFALS 420 human
AAN70008  178 sslyg-------------------leataaesvdeamssaDIAVTCTpsnqpilhrr-----hlrpglhitaMGADTE 231 Pseudomonas putida K...
AAP07893  173 qekfg-------------------kpayvykdpneavreaDIIVTTTnattpvfse-------ilqkgvhvnAVGSFR 224 Bacillus cereus ATCC...
1DIA_A    204 ----------------------------------eevnkgDILVVATgqpemvkg----------ewikpgaIVIDCG 237 human
1GPJ_A    212 gge-----------------------avrfdelvdhlarsDVVVSATaaphpvihvddvrealrkrdrrspiLIIDIA 266 Methanopyrus kandleri
1NPD_A    169 qrvnentdc-----------vvtvtdladqqafaealasaDILTNGTkvgxkplenesl--vndisllhpglLVTECV 233 Escherichia coli

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