Conserved Protein Domain Family
PIKKc_DNA-PK

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cd05172: PIKKc_DNA-PK 
Catalytic domain of DNA-dependent protein kinase
DNA-PK is comprised of a regulatory subunit, containing the Ku70/80 subunit, and a catalytic subunit, which contains a NUC194 domain of unknown function, a FAT (FRAP, ATM and TRRAP) domain, a catalytic domain, and a FATC domain at the C-terminus. It is part of a multi-component system involved in non-homologous end joining (NHEJ), a process of repairing double strand breaks (DSBs) by joining together two free DNA ends of little homology. DNA-PK functions as a molecular sensor for DNA damage that enhances the signal via phosphorylation of downstream targets. It may also act as a protein scaffold that aids the localization of DNA repair proteins to the site of DNA damage. DNA-PK also plays a role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. DNA-PK is a member of the phosphoinositide 3-kinase-related protein kinase (PIKK) subfamily. PIKKs have intrinsic serine/threonine kinase activity and are distinguished from other PKs by their unique catalytic domain, similar to that of lipid PI3K, and their large molecular weight (240-470 kDa). The DNA-PK catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside phosphotransferase, choline kinase, and RIO kinases.
Statistics
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PSSM-Id: 270716
Aligned: 29 rows
Threshold Bit Score: 296.794
Created: 19-Mar-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:ATP binding site [chemical binding site]
Evidence:

cd05172 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd05172 is a member of the superfamily cl21453
Sub-family Hierarchy
cd13968PKc_likecd00142PI3Kc_likecd00891PI3Kccd00896PI3Kc_IIIcd05165PI3Kc_Icd00894PI3Kc_IB_gammacd05173PI3Kc_IA_betacd05174PI3Kc_IA_deltacd05175PI3Kc_IA_alphacd05166PI3Kc_IIcd00895PI3Kc_C2_betacd05176PI3Kc_C2_alphacd05177PI3Kc_C2_gammacd00893PI4Kc_IIIcd05167PI4Kc_III_alphacd05168PI4Kc_III_betacd05164PIKKccd00892PIKKc_ATRcd05163PIKK_TRRAPcd05169PIKKc_TORcd05170PIKKc_SMG1cd05171PIKKc_ATMcd05172PIKKc_DNA-PKcd00180PKccd00192PTKccd05032PTKc_InsR_likecd05061PTKc_InsRcd05062PTKc_IGF-1Rcd05033PTKc_EphRcd05063PTKc_EphR_A2cd05064PTKc_EphR_A10cd05065PTKc_EphR_Bcd05066PTKc_EphR_Acd05034PTKc_Src_likecd05067PTKc_Lck_Blkcd05068PTKc_Frk_likecd05072PTKc_Lyncd05073PTKc_Hckcd05148PTKc_Srm_Brkcd14203PTKc_Src_Fyn_likecd05069PTKc_Yescd05070PTKc_Fyncd05071PTKc_Srccd05035PTKc_TAMcd05074PTKc_Tyro3cd05075PTKc_Axlcd14204PTKc_Mercd05036PTKc_ALK_LTKcd05038PTKc_Jak_rpt2cd05079PTKc_Jak1_rpt2cd05080PTKc_Tyk2_rpt2cd05081PTKc_Jak3_rpt2cd14205PTKc_Jak2_rpt2cd05039PTKc_Csk_likecd05082PTKc_Cskcd05083PTKc_Chkcd05040PTKc_Ack_likecd05041PTKc_Fes_likecd05084PTKc_Fescd05085PTKc_Fercd05042PTKc_Aatykcd05086PTKc_Aatyk2cd05087PTKc_Aatyk1cd14206PTKc_Aatyk3cd05043PTK_Rykcd05044PTKc_c-roscd05045PTKc_RETcd05046PTK_CCK4cd05047PTKc_Tiecd05088PTKc_Tie2cd05089PTKc_Tie1cd05048PTKc_Rorcd05090PTKc_Ror1cd05091PTKc_Ror2cd05049PTKc_Trkcd05092PTKc_TrkAcd05093PTKc_TrkBcd05094PTKc_TrkCcd05050PTKc_Muskcd05051PTKc_DDRcd05095PTKc_DDR2cd05096PTKc_DDR1cd05097PTKc_DDR_likecd05052PTKc_Ablcd05053PTKc_FGFRcd05098PTKc_FGFR1cd05099PTKc_FGFR4cd05100PTKc_FGFR3cd05101PTKc_FGFR2cd05054PTKc_VEGFRcd05102PTKc_VEGFR3cd05103PTKc_VEGFR2cd14207PTKc_VEGFR1cd05055PTKc_PDGFRcd05104PTKc_Kitcd05105PTKc_PDGFR_alphacd05106PTKc_CSF-1Rcd05107PTKc_PDGFR_betacd05056PTKc_FAKcd05057PTKc_EGFR_likecd05108PTKc_EGFRcd05109PTKc_HER2cd05110PTKc_HER4cd05111PTK_HER3cd05058PTKc_Met_Roncd05059PTKc_Tec_likecd05112PTKc_Itkcd05113PTKc_Btk_Bmxcd05114PTKc_Tec_Rlkcd05060PTKc_Syk_likecd05115PTKc_Zap-70cd05116PTKc_Sykcd05037PTK_Jak_rpt1cd05076PTK_Tyk2_rpt1cd05077PTK_Jak1_rpt1cd05078PTK_Jak2_rpt1cd14208PTK_Jak3_rpt1cd05117STKc_CAMKcd14082STKc_PKDcd14083STKc_CaMKIcd14166STKc_CaMKI_gammacd14167STKc_CaMKI_alphacd14168STKc_CaMKI_deltacd14169STKc_CaMKI_betacd14084STKc_Chk2cd14085STKc_CaMKIVcd14086STKc_CaMKIIcd14087STKc_PSKH1cd14088STKc_CaMK_likecd14089STKc_MAPKAPKcd14170STKc_MAPKAPK2cd14171STKc_MAPKAPK5cd14172STKc_MAPKAPK3cd14090STKc_Mnkcd14173STKc_Mnk2cd14174STKc_Mnk1cd14091STKc_RSK_Ccd14175STKc_RSK1_Ccd14176STKc_RSK2_Ccd14177STKc_RSK4_Ccd14178STKc_RSK3_Ccd14092STKc_MSK_Ccd14179STKc_MSK1_Ccd14180STKc_MSK2_Ccd14093STKc_PhKGcd14181STKc_PhKG2cd14182STKc_PhKG1cd14094STKc_CASKcd14095STKc_DCKLcd14183STKc_DCKL1cd14184STKc_DCKL2cd14185STKc_DCKL3cd14096STKc_RCK1-likecd14097STKc_STK33cd14098STKc_Rad53_Cds1cd05118STKc_CMGCcd07829STKc_CDK_likecd07835STKc_CDK1_CdkB_likecd07837STKc_CdkB_plantcd07860STKc_CDK2_3cd07861STKc_CDK1_eukcd07836STKc_Pho85cd07838STKc_CDK4_6_likecd07862STKc_CDK6cd07863STKc_CDK4cd07839STKc_CDK5cd07840STKc_CDK9_likecd07864STKc_CDK12cd07865STKc_CDK9cd07866STKc_BUR1cd07841STKc_CDK7cd07842STKc_CDK8_likecd07867STKc_CDC2L6cd07868STKc_CDK8cd07843STKc_CDC2L1cd07844STKc_PCTAIRE_likecd07869STKc_PFTAIRE1cd07870STKc_PFTAIRE2cd07871STKc_PCTAIRE3cd07872STKc_PCTAIRE2cd07873STKc_PCTAIRE1cd07845STKc_CDK10cd07830STKc_MAK_likecd07831STKc_MOKcd07832STKc_CCRKcd07833STKc_CDKLcd07846STKc_CDKL2_3cd07847STKc_CDKL1_4cd07848STKc_CDKL5cd07834STKc_MAPKcd07849STKc_ERK1_2_likecd07850STKc_JNKcd07874STKc_JNK3cd07875STKc_JNK1cd07876STKc_JNK2cd07851STKc_p38cd07877STKc_p38alphacd07878STKc_p38betacd07879STKc_p38deltacd07880STKc_p38gammacd07852STKc_MAPK15-likecd07853STKc_NLKcd07854STKc_MAPK4_6cd07855STKc_ERK5cd07856STKc_Sty1_Hog1cd07857STKc_MPK1cd07858STKc_TEY_MAPKcd07859STKc_TDY_MAPKcd14132STKc_CK2_alphacd14133PKc_DYRK_likecd14210PKc_DYRKcd14224PKc_DYRK2_3cd14225PKc_DYRK4cd14226PKc_DYRK1cd14211STKc_HIPKcd14227STKc_HIPK2cd14228STKc_HIPK1cd14229STKc_HIPK3cd14212PKc_YAK1cd14134PKc_CLKcd14213PKc_CLK1_4cd14214PKc_CLK3cd14215PKc_CLK2cd14135STKc_PRP4cd14136STKc_SRPKcd14216STKc_SRPK1cd14217STKc_SRPK2cd14218STKc_SRPK3cd14137STKc_GSK3cd05122PKc_STEcd06605PKc_MAPKKcd06615PKc_MEKcd06649PKc_MEK2cd06650PKc_MEK1cd06616PKc_MKK4cd06617PKc_MKK3_6cd06618PKc_MKK7cd06619PKc_MKK5cd06620PKc_Byr1_likecd06621PKc_Pek1_likecd06622PKc_PBS2_likecd06623PKc_MAPKK_plant_likecd06606STKc_MAPKKKcd06624STKc_ASKcd06625STKc_MEKK3_likecd06651STKc_MEKK3cd06652STKc_MEKK2cd06653STKc_MEKK3_like_u1cd06626STKc_MEKK4cd06627STKc_Cdc7_likecd06628STKc_Byr2_likecd06629STKc_Bck1_likecd06630STKc_MEKK1cd06631STKc_YSK4cd06632STKc_MEKK1_plantcd06607STKc_TAOcd06633STKc_TAO3cd06634STKc_TAO2cd06635STKc_TAO1cd06608STKc_myosinIII_N_likecd06636STKc_MAP4K4_6_Ncd06637STKc_TNIKcd06638STKc_myosinIIIA_Ncd06639STKc_myosinIIIB_Ncd06609STKc_MST3_likecd06640STKc_MST4cd06641STKc_MST3cd06642STKc_STK25cd06917STKc_NAK1_likecd06610STKc_OSR1_SPAKcd06611STKc_SLK_likecd06643STKc_SLKcd06644STKc_STK10cd06612STKc_MST1_2cd06613STKc_MAP4K3_likecd06645STKc_MAP4K3cd06646STKc_MAP4K5cd06614STKc_PAKcd06647STKc_PAK_Icd06654STKc_PAK1cd06655STKc_PAK2cd06656STKc_PAK3cd06648STKc_PAK_IIcd06657STKc_PAK4cd06658STKc_PAK5cd06659STKc_PAK6cd14131PKc_Mps1cd05123STKc_AGCcd05570STKc_PKCcd05587STKc_cPKCcd05615STKc_cPKC_alphacd05616STKc_cPKC_betacd05588STKc_aPKCcd05617STKc_aPKC_zetacd05618STKc_aPKC_iotacd05589STKc_PKNcd05590STKc_nPKC_etacd05591STKc_nPKC_epsiloncd05592STKc_nPKC_theta_likecd05619STKc_nPKC_thetacd05620STKc_nPKC_deltacd05571STKc_PKBcd05593STKc_PKB_gammacd05594STKc_PKB_alphacd05595STKc_PKB_betacd05572STKc_cGKcd05573STKc_ROCK_NDR_likecd05596STKc_ROCKcd05621STKc_ROCK2cd05622STKc_ROCK1cd05597STKc_DMPK_likecd05623STKc_MRCK_alphacd05624STKc_MRCK_betacd05598STKc_LATScd05625STKc_LATS1cd05626STKc_LATS2cd05599STKc_NDR_likecd05627STKc_NDR2cd05628STKc_NDR1cd05629STKc_NDR_like_fungalcd05600STKc_Sid2p_likecd05601STKc_CRIKcd05574STKc_phototropin_likecd05575STKc_SGKcd05602STKc_SGK1cd05603STKc_SGK2cd05604STKc_SGK3cd05576STKc_RPK118_likecd05577STKc_GRKcd05605STKc_GRK4_likecd05630STKc_GRK6cd05631STKc_GRK4cd05632STKc_GRK5cd05606STKc_beta_ARKcd05633STKc_GRK3cd14223STKc_GRK2cd05607STKc_GRK7cd05608STKc_GRK1cd05578STKc_Yank1cd05579STKc_MAST_likecd05609STKc_MASTcd05610STKc_MASTLcd05611STKc_Rim15_likecd05580STKc_PKA_likecd05612STKc_PRKX_likecd14209STKc_PKAcd05581STKc_PDK1cd05582STKc_RSK_Ncd05583STKc_MSK_Ncd05613STKc_MSK1_Ncd05614STKc_MSK2_Ncd05584STKc_p70S6Kcd05585STKc_YPK1_likecd05586STKc_Sck1_likecd08215STKc_Nekcd08217STKc_Nek2cd08218STKc_Nek1cd08219STKc_Nek3cd08220STKc_Nek8cd08221STKc_Nek9cd08222STKc_Nek11cd08223STKc_Nek4cd08224STKc_Nek6_7cd08228STKc_Nek6cd08229STKc_Nek7cd08225STKc_Nek5cd08528STKc_Nek10cd08529STKc_FA2-likecd08530STKc_CNK2-likecd08216PK_STRADcd08226PK_STRAD_betacd08227PK_STRAD_alphacd13973PK_MviN-likecd13974STKc_SHIKcd13975PKc_Dustycd13976PK_TRBcd14022PK_TRB2cd14023PK_TRB1cd14024PK_TRB3cd13977STKc_PDIK1Lcd13978STKc_RIPcd14025STKc_RIP4_likecd14026STKc_RIP2cd14027STKc_RIP1cd13979STKc_Moscd13980STKc_Vps15cd13981STKc_Bub1_BubR1cd14028STKc_Bub1_vertcd14029STKc_BubR1_vertcd13982STKc_IRE1cd13983STKc_WNKcd14030STKc_WNK1cd14031STKc_WNK3cd14032STKc_WNK2_likecd14033STKc_WNK4cd13984PK_NRBP1_likecd14034PK_NRBP1cd14035PK_MADMLcd13985STKc_GAK_likecd14036STKc_GAKcd14037STKc_NAK_likecd13986STKc_16cd13987STKc_SBK1cd13988STKc_TBK1cd13989STKc_IKKcd14038STKc_IKK_betacd14039STKc_IKK_alphacd13990STKc_TLKcd14040STKc_TLK1cd14041STKc_TLK2cd13991STKc_NIKcd13992PK_GCcd14042PK_GC-A_Bcd14043PK_GC-2Dcd14044PK_GC-Ccd14045PK_GC_unkcd13993STKc_Pat1_likecd13994STKc_HAL4_likecd13995STKc_MAP3K8cd13996STKc_EIF2AKcd14046STKc_EIF2AK4_GCN2_rpt2cd14047STKc_EIF2AK2_PKRcd14048STKc_EIF2AK3_PERKcd14049STKc_EIF2AK1_HRIcd13997PKc_Wee1_likecd14050PKc_Myt1cd14051PTKc_Wee1cd14138PTKc_Wee1acd14139PTKc_Wee1bcd14052PTKc_Wee1_fungicd13998STKc_TGFbR-likecd14053STKc_ACVR2cd14140STKc_ACVR2bcd14141STKc_ACVR2acd14054STKc_BMPR2_AMHR2cd14055STKc_TGFbR2_likecd14056STKc_TGFbR_Icd14142STKc_ACVR1_ALK1cd14143STKc_TGFbR1_ACVR1b_ACVR1ccd14144STKc_BMPR1cd14219STKc_BMPR1bcd14220STKc_BMPR1acd13999STKc_MAP3K-likecd14057PK_ILKcd14058STKc_TAK1cd14059STKc_MAP3K12_13cd14060STKc_MLTKcd14061STKc_MLKcd14145STKc_MLK1cd14146STKc_MLK4cd14147STKc_MLK3cd14148STKc_MLK2cd14062STKc_Rafcd14149STKc_C-Rafcd14150STKc_A-Rafcd14151STKc_B-Rafcd14063PK_KSRcd14152STKc_KSR1cd14153PK_KSR2cd14064PKc_TNNI3Kcd14065PKc_LIMK_likecd14154STKc_LIMKcd14221STKc_LIMK1cd14222STKc_LIMK2cd14155PKc_TESKcd14156PKc_LIMK_like_unkcd14066STKc_IRAKcd14157STKc_IRAK2cd14158STKc_IRAK4cd14159STKc_IRAK1cd14160PK_IRAK3cd14664STK_BAK1_likecd14000STKc_LRRKcd14067STKc_LRRK1cd14068STKc_LRRK2cd14001PKc_TOPKcd14002STKc_STK36cd14003STKc_AMPK-likecd14069STKc_Chk1cd14070STKc_HUNKcd14071STKc_SIKcd14072STKc_MARKcd14073STKc_NUAKcd14161STKc_NUAK2cd14074STKc_SNRKcd14075STKc_NIM1cd14076STKc_Kin4cd14077STKc_Kin1_2cd14078STKc_MELKcd14079STKc_AMPK_alphacd14080STKc_TSSK-likecd14162STKc_TSSK4-likecd14163STKc_TSSK3-likecd14164STKc_TSSK6-likecd14165STKc_TSSK1_2-likecd14081STKc_BRSK1_2cd14662STKc_SnRK2cd14665STKc_SnRK2-3cd14663STKc_SnRK3cd14004STKc_PASKcd14005STKc_PIMcd14100STKc_PIM1cd14101STKc_PIM2cd14102STKc_PIM3cd14006STKc_MLCK-likecd14103STKc_MLCKcd14190STKc_MLCK2cd14191STKc_MLCK1cd14192STKc_MLCK3cd14193STKc_MLCK4cd14104STKc_Titincd14105STKc_DAPKcd14194STKc_DAPK1cd14195STKc_DAPK3cd14196STKc_DAPK2cd14106STKc_DRAKcd14197STKc_DRAK1cd14198STKc_DRAK2cd14107STKc_obscurin_rpt1cd14108STKc_SPEG_rpt1cd14109PK_Unc-89_rpt1cd14110STKc_obscurin_rpt2cd14111STKc_SPEG_rpt2cd14112STKc_Unc-89_rpt2cd14113STKc_Trio_Ccd14114STKc_Twitchin_likecd14115STKc_Kalirin_Ccd14007STKc_Auroracd14116STKc_Aurora-Acd14117STKc_Aurora-B_likecd14008STKc_LKB1_CaMKKcd14118STKc_CAMKKcd14199STKc_CaMKK2cd14200STKc_CaMKK1cd14119STKc_LKB1cd14009STKc_ATG1_ULK_likecd14120STKc_ULK1_2-likecd14201STKc_ULK2cd14202STKc_ULK1cd14121STKc_ULK3cd14010STKc_ULK4cd14011PK_SCY1_likecd14012PK_eIF2AK_GCN2_rpt1cd14013STKc_SNT7_plantcd14014STKc_PknB_likecd14015STKc_VRKcd14122STKc_VRK1cd14123STKc_VRK2cd14124PK_VRK3cd14016STKc_CK1cd14125STKc_CK1_delta_epsiloncd14126STKc_CK1_gammacd14127STKc_CK1_fungalcd14128STKc_CK1_alphacd14017STKc_TTBKcd14129STKc_TTBK2cd14130STKc_TTBK1cd14018STKc_PINK1cd14019STKc_Cdc7cd14020STKc_KIScd14099STKc_PLKcd14186STKc_PLK4cd14187STKc_PLK1cd14188STKc_PLK2cd14189STKc_PLK3cd05119RIOcd05144RIO2_Ccd05145RIO1_likecd05146RIO3_eukcd05147RIO1_eukcd05120APH_ChoK_likecd05150APHcd05151ChoK-likecd14021ChoK-like_eukcd05156ChoK_eukcd05157ETNK_eukcd05152MPH2'cd05153HomoserineK_IIcd05154ACAD10_11_N-likecd05155APH_ChoK_like_1cd05121ABC1_ADCK3-likecd13969ADCK1-likecd13970ABC1_ADCK3cd13971ADCK2-likecd13972UbiBcd05124AFK
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                # ## # #               # #  #                                  #      
P78527    3719 IAGFDERVTVMASL-RRPKRIIIRGHDEreHPFLVKGGEDLRQDQRVEQLFQVMNGILAqdsacsqrALQLRTYSVVPMT 3797 human
CAL57285  3536 VMGFAPDVQIFASK-QRPKKIIMRGSDGqdYAFIAKGGEDLRQDERIQQLFRAMNGMLAsftesrgrRMEVRTFHVAPLT 3614 Ostreococcus tauri
EEZ99162  3278 ISGFCPNVSIMSSL-RKPIKITILGNDTkeYPFLVKFGEDVRQDQRIQQLFSLMNNIFQhdrnlngrKFHILTYQVIPLT 3356 red flour beetle
EEH60179    34 IVGFEPEVDVFASK-QRPKKLIARGGDGreYAFIAKGSEDLRQDDRIQRLFRAMDALLAsspaarskALRVRTFHVAPLS 112  Micromonas pusil...
EGI63049  3419 IARFEPQVEVMQSL-RKPIRINIIGDNGkeYKFLVKFGEDLTIDRGLQQLYSTMNKTLRndpscrqrRLAIDTYEVIPIS 3497 Panamanian leafc...
EDQ69564  3729 LLGFDQVLICLKSK-QRPKILTMRGSDEndYKFVVKGGEDLRLDQRIEQLFEAMNNVLNrdaacsqrKLAIRTYSVIPVS 3807 Physcomitrella p...
EFJ09668   111 LVGFDETLIGLSSK-QRPKILTMRGSDEkeYKFIVKGGEDLRLDQRIEQLFAKMNSVLRedgacakrELSMRTYAVIPVS 189  Selaginella moel...
EFJ51181  3427 VVGFKRVVTVFSSK-QRPKLLTLYCSDLstREFVVKGGEDVRLDERIQQLYDAMNGVTAhdaacarrSLRVPVYDVIPLS 3505 Volvox carteri f...
CCO65984  3778 IVSFETNATIFTQSkQKPKKITLRGSDGreYAFIAKGSEDLRQDERIQRLYRAMDSLLTqspsarakALRIRTFHVLPLT 3857 Bathycoccus pras...
EFR21746  3650 IVKIVPEVQVFDATlRAPVLLTFRGSDGraHRFLAKSGEDLRQDQRIQQLQQEITYRLQydrccreqRLELRSYQVIPIR 3729 Anopheles darlingi
Feature 1           ####    #                                                                  
P78527    3798 SRLGLIEWLENTVTLKDLLLNtmsqeekaaylsdprappceykdwltkmsgk---------------------------- 3849 human
CAL57285  3615 PRTGLIEFLSNTSPLLRLLSKpvtgmdidpfkehqrwirehargigkrkrdiaqge-----------------------m 3671 Ostreococcus tauri
EEZ99162  3357 TSLGIIQWIGNTKSLHEFSNNenfdkvvetftkwiytsanqspfday--------------------------------- 3403 red flour beetle
EEH60179   113 TRCGLLEFVGGTVPLLHALTSstkraqlhseahqktdggvsaddylaamart---------------------------- 164  Micromonas pusil...
EGI63049  3498 SSFGLIQWIEDTRSLDELICLtlsdkekdccqnivekyakwiqkaapekrl----------------------------- 3548 Panamanian leafc...
EDQ69564  3808 KKCGLLQFVENTCVLQEVIRDglssklasrthegykplqatsetllkeiqheyiewvr------------------kkgg 3869 Physcomitrella p...
EFJ09668   190 QQCGLLQFVDNTCVLDDVIKDgvaqqlaaakrkekagdllvelrnqyhqwvekkg------------------------g 245  Selaginella moel...
EFJ51181  3506 PTVGLLQFVPGTRPLQSCLVDnperaeqeaqaielyanyirsaaastvqprqqhqahaap--------------glaapg 3571 Volvox carteri f...
CCO65984  3858 RRSGLIEFVHGTEPVGRILLNssddakknignvsarheafikargmfglsgkkrkeidgdaliqedkmgvmcdltkvprp 3937 Bathycoccus pras...
EFR21746  3730 RDYGLIGWLEDTVSLKDIARRatprynpndrgpnyvleeygrfllqasrhgtvdepi--------------------tns 3789 Anopheles darlingi
Feature 1                                                                                      
P78527    3850 --hdvgaymlmykganrtetvtsfrkreskvpaDLLKRAFVRMSts-pEAFLALRSHFASSHALICISHWILGIGDRHLN 3926 human
CAL57285  3672 ttthedylaainkasckesetilsrlrssshsnNALRNILLECAgn-aEAFLMMRQAFAASLSSSSICGYVAGVGDRHLD 3750 Ostreococcus tauri
EEZ99162  3404 --------graamkysrdktivkfktlvskiswDVFRSTFLKLSsn-tEGFFALRNNFIKSYAIMCASHWIVGVGDRHLS 3474 red flour beetle
EEH60179   165 --papeaaraleslsrraaaeaspggeqrppesPALRTTLMNAAgs-pDAFLSLRRTYASSLAATSVCGWVAGVGDRHLQ 241  Micromonas pusil...
EGI63049  3549 ---irdfyieavskynqqavtenmncliretkqTALRDAFNSISps-pDCFVTLRRNFIISYATMCVAHWLAGIGDRHLQ 3624 Panamanian leafc...
EDQ69564  3870 gksqtecycnlyrkvgfeevslklsalqgqlpwDTLRMGFSRLVts-aESYLALRSQFARSLSVTSICGYVAGVGDRHLG 3948 Physcomitrella p...
EFJ09668   246 sksvhdcyknlytkvkagemearmnalvaqvpwDALKTGLYKRTss-aESFLAMRSQFARSLSVMSICGYIAGVGDRHLA 324  Selaginella moel...
EFJ51181  3572 qlpgprdywqmyiqadsastvrhfkqavgclpaGLLRSFLLRVSghspELFLARRGALVSGLVAGSVFGYLAGVGDRHTS 3651 Volvox carteri f...
CCO65984  3938 ahddyltamanaelnaskkvlrglghpghspakDAIRQKLQVSSgc-pEAFLAARRVFAASLAASSISGWIVGLGDRHCE 4016 Bathycoccus pras...
EFR21746  3790 vlkssdlygrvaaygdprrlalkyielkqtirsDTLKRALFDMAvs-pEAFYRLRMNFGRSLATMNVTCWVLGIGDRHLS 3868 Anopheles darlingi
Feature 1      # #          ##                                                                 
P78527    3927 NFMVAmeTGGVIGIDFGHAFGSATQfLPVPELMPFRLTRQFINLMLpMKETGLMYSIMVHALRAFRSD--PGLLTNTMDV 4004 human
CAL57285  3751 NILLDlsTGQLVHIDFGYAFGTATSaLPIPELVPFRATPALLDVLApMSARTWLETDMARTVKALQNG--STLLKGVMDI 3828 Ostreococcus tauri
EEZ99162  3475 NSLVClnSGKVLGIDFGHAFGTATQiLPVPELVPFRLTPHIVNLMEpLGATGLFREIMVHCLRSLRSN--SASLLSTMNV 3552 red flour beetle
EEH60179   242 NILLDltDGSLVHIDFGYAFGTATAvLPIPELVPFRATGALLGGLApNDAKTALRGDMTAAMHALRRG--SALLRGVMDV 319  Micromonas pusil...
EGI63049  3625 NILVRvaTGRCLGIDFGHAFGSGIG-ASVPELVPFRLTPQILELLRpFTERDLLATIMTHTMQALRDD--QGPILACMDI 3701 Panamanian leafc...
EDQ69564  3949 NTLVDmrTGALVPIDFGYSFGTNVLlLPVPELVPFRLTAQLKNFLLpLTAVGLLRSDMVRIMTALRGS--RGLISAVMEV 4026 Physcomitrella p...
EFJ09668   325 NTLIDmqTGSLVPIDFGYSFGTGVIlLPVPELIPFRLTPQLTNVLLpLDSLGLLKNDMVRVLSALHKS--RQMICAVMDV 402  Selaginella moel...
EFJ51181  3652 NLLLQpaTGRLVHIDFGYSLGAATQvVPIPELVPFRLTPQLLGALQpHCGKEVMVPGMAAALAALSAPpaRQLLAAVMEV 3731 Volvox carteri f...
CCO65984  4017 NILLDvaHGSLIHVDFGYAFGTGTStLPIPEIVPFRATRTFLGALEpLDAKEWLEADMARVLTALQSG--KNLLEGAMDI 4094 Bathycoccus pras...
EFR21746  3869 NIVLErsTGKLAGVDFGLAFGAGTRdLPIPELVPFRLTPQFIGVMEpLRLSGILHKCHLYTLQCLRDA--RKLLRACLEV 3946 Anopheles darlingi
Feature 1                 
P78527    4005 FVKEPSFDWKN 4015 human
CAL57285  3829 FLREPLIDWER 3839 Ostreococcus tauri
EEZ99162  3553 FIEEPSLDWLE 3563 red flour beetle
EEH60179   320 FLREPLIDWQR 330  Micromonas pusilla CCMP1545
EGI63049  3702 FVYKPIQWLNI 3712 Panamanian leafcutter ant
EDQ69564  4027 FVKEPLVDWRQ 4037 Physcomitrella patens subsp. patens
EFJ09668   403 FVREPLVDWKK 413  Selaginella moellendorffii
EFJ51181  3732 FLREPVADWQQ 3742 Volvox carteri f. nagariensis
CCO65984  4095 FIRDPILDWTR 4105 Bathycoccus prasinos
EFR21746  3947 FIREPTLDWLE 3957 Anopheles darlingi

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