1KHC,1H3Z,1N27,2DAQ,2GFU


Conserved Protein Domain Family
PWWP

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cd05162: PWWP 
Click on image for an interactive view with Cn3D
The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins seem to be nuclear, often DNA-binding, proteins that function as transcription factors regulating a variety of developmental processes. The function of the PWWP domain is still not known precisely; however, based on the fact that other regions of PWWP-domain proteins are responsible for nuclear localization and DNA-binding, is likely that the PWWP domain acts as a site for protein-protein binding interactions, influencing chromatin remodeling and thereby regulating transcriptional processes. Some PWWP-domain proteins have been linked to cancer or other diseases; some are known to function as growth factors.
Statistics
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PSSM-Id: 99894
View PSSM: cd05162
Aligned: 13 rows
Threshold Bit Score: 80.5151
Threshold Setting Gi: 74762184
Created: 25-Apr-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:putative chromatin binding site
Evidence:
  • Comment:Possible chromatin binding property is supported by its charasteristic electrostatic charge distribution. Upon binding, the charged surfaces may form nonspecific contacts with the nucleic acid on the basic side and contact the core histone molecules along the acidic surface.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                   #  #  #                                          #       # #          
1KHC_A         12 FGIGDLVWGKIkgFSWWPAMVVSwkatskr-------------------qampgmRWVQWFg-----DGKFSEISADKLV 67   house mouse
1H3Z_A          7 YKPGMRVLTKMsgFPWWPSMVVTeskmtsvark-------------skpkragtfYPVIFFp-----NKEYLWTGSDSLT 68   fission yeast
1N27_A          9 YKAGDLVFAKMkgYPHWPARIDElpegav--------------------kppankYPIFFFg-----THETAFLGPKDLF 63   house mouse
2DAQ_A          9 LHYKQIVWVKLgnYRWWPAEICNprsvplniq---------------glkhdlgdFPVFFFg-----SHDYYWVHQGRVF 68   human
2GFU_A         23 FSPGDLVWAKMegYPWWPSLVYNhpfdgtfi----------------rekgksvrVHVQFFd----dSPTRGWVSKRLLK 82   human
Q15326        238 IPNHELVWAKMkgFGFWPAKVMQked---------------------------nqVDVRFFg----hHHQRAWIPSENIQ 286  human
XP_001599557  862 LTALQLVWAKCrgYPWYPALIIDpntprgtvhkgvpipsppddvlalasnykdrvYLVLFFd----tKRTWQWLPGEKLE 937  jewel wasp
AAH47223        6 LRLGDLVWGKLgrYPPWPGKIVNppkdlkk-------------------prgkkcFFVKFFg-----TEDHAWIKVEQLK 61   human
Q5H9M0        390 FETGMIVWFKYqkYPFWPAVIKSirrk-------------------------erkASVLFVeanmnsEKKGIRVNFRRLK 444  human
NP_187578     197 ISDSDLVWAKVrsHPWWPGQVFDasaatdka----------------kkhfkkgsFLVTYFg-----DCTFAWNEASRIK 255  thale cress
AAX94928      114 FAPPELVWGKVrsHPWWPGQVFDaadaskla----------------lkhtragaPLVAYFw-----DKTFAWSDASSLL 172  Japanese rice
AAV24808       44 VRFGDMVWGKVksHPWWPGHVYSitltsdgev---------------rrgyrdglVLVAFFg-----DSSYGWFEPHELL 103  Japanese rice
XP_001422099  596 PRRNQLVWAKLpgHPFWPGLRADldkdfipad--------------alamareneVLVVFFg-----ENSFGWLRAEHCL 656  Ostreococcus ...
Feature 1                                            
1KHC_A         68 Alglfsqhf-----nlatfnklVSYRKAMYHTLEK 97   house mouse
1H3Z_A         69 Pltseaisqf----lekpkpktASLIKAYKMAQST 99   fission yeast
1N27_A         64 Pykeykdk-------fgksnkrKGFNEGLWEIENS 91   house mouse
2DAQ_A         69 Pyvegdksf-----aegqtsinKTFKKALEEAAKR 98   human
2GFU_A         83 Pytgskskeaq--kgghfysakPEILRAMQRADEA 115  human
Q15326        287 Ditvnihr--------lhvkrsMGWKKACDELELH 313  human
XP_001599557  938 PlgvsqelddgkliesrkptdrKAVKKAYQDALLY 972  jewel wasp
AAH47223       62 Pyhahkee-------mikinkgKRFQQAVDAVEEF 89   human
Q5H9M0        445 Kfdcke-----------kqmlvDKAREDYSESIDW 468  human
NP_187578     256 Pfrqhfsq-------makqsslPDFIDAIDFALEE 283  thale cress
AAX94928      173 Pfcsnftr-------lasqstmSGFVSAVDAALQE 200  Japanese rice
AAV24808      104 Pfeehfre-------kfaqpggRNFPTAIDEAADE 131  Japanese rice
XP_001422099  657 Dftehyask-----srdparnkARFQAAVKQANEE 686  Ostreococcus lucimarinus CCE9901

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