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Catalytic domain of the Protein Tyrosine Kinase, Kit
PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Kit is important in the development of melanocytes, germ cells, mast cells, hematopoietic stem cells, the interstitial cells of Cajal, and the pacemaker cells of the GI tract. Kit signaling is involved in major cellular functions including cell survival, proliferation, differentiation, adhesion, and chemotaxis. Mutations in Kit, which result in constitutive ligand-independent activation, are found in human cancers such as gastrointestinal stromal tumor (GIST) and testicular germ cell tumor (TGCT). The aberrant expression of Kit and/or SCF is associated with other tumor types such as systemic mastocytosis and cancers of the breast, neurons, lung, prostate, colon, and rectum. Although the structure of the human Kit catalytic domain is known, it is excluded from this specific alignment model because it contains a deletion in its sequence. Kit is a member of the Platelet Derived Growth Factor Receptor (PDGFR) subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with five immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of Kit to its ligand, the stem-cell factor (SCF), leads to receptor dimerization, trans phosphorylation and activation, and intracellular signaling. The Kit subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Conserved Features/Sites ?
Feature 1: active site [active site]
Evidence: Comment: includes ATP binding and substrate binding sites
Comment: Based on the structures of other PTK family members bound to substrate peptides and ATP analogs, as well as the structure of human c-Kit bound to MgADP.
cd05104 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd05104 is a member of the superfamily cl21453 Sub-family Hierarchy
Interactive Display with CDTree cd13968 PKc_like cd00142 PI3Kc_like cd00891 PI3Kc cd00896 PI3Kc_III cd05165 PI3Kc_I cd00894 PI3Kc_IB_gamma cd05173 PI3Kc_IA_beta cd05174 PI3Kc_IA_delta cd05175 PI3Kc_IA_alpha cd05166 PI3Kc_II cd00895 PI3Kc_C2_beta cd05176 PI3Kc_C2_alpha cd05177 PI3Kc_C2_gamma cd00893 PI4Kc_III cd05167 PI4Kc_III_alpha cd05168 PI4Kc_III_beta cd05164 PIKKc cd00892 PIKKc_ATR cd05163 PIKK_TRRAP cd05169 PIKKc_TOR cd05170 PIKKc_SMG1 cd05171 PIKKc_ATM cd05172 PIKKc_DNA-PK cd00180 PKc cd00192 PTKc cd05032 PTKc_InsR_like cd05061 PTKc_InsR cd05062 PTKc_IGF-1R cd05033 PTKc_EphR cd05063 PTKc_EphR_A2 cd05064 PTKc_EphR_A10 cd05065 PTKc_EphR_B cd05066 PTKc_EphR_A cd05034 PTKc_Src_like cd05067 PTKc_Lck_Blk cd05068 PTKc_Frk_like cd05072 PTKc_Lyn cd05073 PTKc_Hck cd05148 PTKc_Srm_Brk cd14203 PTKc_Src_Fyn_like cd05069 PTKc_Yes cd05070 PTKc_Fyn cd05071 PTKc_Src cd05035 PTKc_TAM cd05074 PTKc_Tyro3 cd05075 PTKc_Axl cd14204 PTKc_Mer cd05036 PTKc_ALK_LTK cd05038 PTKc_Jak_rpt2 cd05079 PTKc_Jak1_rpt2 cd05080 PTKc_Tyk2_rpt2 cd05081 PTKc_Jak3_rpt2 cd14205 PTKc_Jak2_rpt2 cd05039 PTKc_Csk_like cd05082 PTKc_Csk cd05083 PTKc_Chk cd05040 PTKc_Ack_like cd05041 PTKc_Fes_like cd05084 PTKc_Fes cd05085 PTKc_Fer cd05042 PTKc_Aatyk cd05086 PTKc_Aatyk2 cd05087 PTKc_Aatyk1 cd14206 PTKc_Aatyk3 cd05043 PTK_Ryk cd05044 PTKc_c-ros cd05045 PTKc_RET cd05046 PTK_CCK4 cd05047 PTKc_Tie cd05088 PTKc_Tie2 cd05089 PTKc_Tie1 cd05048 PTKc_Ror cd05090 PTKc_Ror1 cd05091 PTKc_Ror2 cd05049 PTKc_Trk cd05092 PTKc_TrkA cd05093 PTKc_TrkB cd05094 PTKc_TrkC cd05050 PTKc_Musk cd05051 PTKc_DDR cd05095 PTKc_DDR2 cd05096 PTKc_DDR1 cd05097 PTKc_DDR_like cd05052 PTKc_Abl cd05053 PTKc_FGFR cd05098 PTKc_FGFR1 cd05099 PTKc_FGFR4 cd05100 PTKc_FGFR3 cd05101 PTKc_FGFR2 cd05054 PTKc_VEGFR cd05102 PTKc_VEGFR3 cd05103 PTKc_VEGFR2 cd14207 PTKc_VEGFR1 cd05055 PTKc_PDGFR cd05104 PTKc_Kit cd05105 PTKc_PDGFR_alpha cd05106 PTKc_CSF-1R cd05107 PTKc_PDGFR_beta cd05056 PTKc_FAK cd05057 PTKc_EGFR_like cd05108 PTKc_EGFR cd05109 PTKc_HER2 cd05110 PTKc_HER4 cd05111 PTK_HER3 cd05058 PTKc_Met_Ron cd05059 PTKc_Tec_like cd05112 PTKc_Itk cd05113 PTKc_Btk_Bmx cd05114 PTKc_Tec_Rlk cd05060 PTKc_Syk_like cd05115 PTKc_Zap-70 cd05116 PTKc_Syk cd05037 PTK_Jak_rpt1 cd05076 PTK_Tyk2_rpt1 cd05077 PTK_Jak1_rpt1 cd05078 PTK_Jak2_rpt1 cd14208 PTK_Jak3_rpt1 cd05117 STKc_CAMK cd14082 STKc_PKD cd14083 STKc_CaMKI cd14166 STKc_CaMKI_gamma cd14167 STKc_CaMKI_alpha cd14168 STKc_CaMKI_delta cd14169 STKc_CaMKI_beta cd14084 STKc_Chk2 cd14085 STKc_CaMKIV cd14086 STKc_CaMKII cd14087 STKc_PSKH1 cd14088 STKc_CaMK_like cd14089 STKc_MAPKAPK cd14170 STKc_MAPKAPK2 cd14171 STKc_MAPKAPK5 cd14172 STKc_MAPKAPK3 cd14090 STKc_Mnk cd14173 STKc_Mnk2 cd14174 STKc_Mnk1 cd14091 STKc_RSK_C cd14175 STKc_RSK1_C cd14176 STKc_RSK2_C cd14177 STKc_RSK4_C cd14178 STKc_RSK3_C cd14092 STKc_MSK_C cd14179 STKc_MSK1_C cd14180 STKc_MSK2_C cd14093 STKc_PhKG cd14181 STKc_PhKG2 cd14182 STKc_PhKG1 cd14094 STKc_CASK cd14095 STKc_DCKL cd14183 STKc_DCKL1 cd14184 STKc_DCKL2 cd14185 STKc_DCKL3 cd14096 STKc_RCK1-like cd14097 STKc_STK33 cd14098 STKc_Rad53_Cds1 cd05118 STKc_CMGC cd07829 STKc_CDK_like cd07835 STKc_CDK1_CdkB_like cd07837 STKc_CdkB_plant cd07860 STKc_CDK2_3 cd07861 STKc_CDK1_euk cd07836 STKc_Pho85 cd07838 STKc_CDK4_6_like cd07862 STKc_CDK6 cd07863 STKc_CDK4 cd07839 STKc_CDK5 cd07840 STKc_CDK9_like cd07864 STKc_CDK12 cd07865 STKc_CDK9 cd07866 STKc_BUR1 cd07841 STKc_CDK7 cd07842 STKc_CDK8_like cd07867 STKc_CDC2L6 cd07868 STKc_CDK8 cd07843 STKc_CDC2L1 cd07844 STKc_PCTAIRE_like cd07869 STKc_PFTAIRE1 cd07870 STKc_PFTAIRE2 cd07871 STKc_PCTAIRE3 cd07872 STKc_PCTAIRE2 cd07873 STKc_PCTAIRE1 cd07845 STKc_CDK10 cd07830 STKc_MAK_like cd07831 STKc_MOK cd07832 STKc_CCRK cd07833 STKc_CDKL cd07846 STKc_CDKL2_3 cd07847 STKc_CDKL1_4 cd07848 STKc_CDKL5 cd07834 STKc_MAPK cd07849 STKc_ERK1_2_like cd07850 STKc_JNK cd07874 STKc_JNK3 cd07875 STKc_JNK1 cd07876 STKc_JNK2 cd07851 STKc_p38 cd07877 STKc_p38alpha cd07878 STKc_p38beta cd07879 STKc_p38delta cd07880 STKc_p38gamma cd07852 STKc_MAPK15-like cd07853 STKc_NLK cd07854 STKc_MAPK4_6 cd07855 STKc_ERK5 cd07856 STKc_Sty1_Hog1 cd07857 STKc_MPK1 cd07858 STKc_TEY_MAPK cd07859 STKc_TDY_MAPK cd14132 STKc_CK2_alpha cd14133 PKc_DYRK_like cd14210 PKc_DYRK cd14224 PKc_DYRK2_3 cd14225 PKc_DYRK4 cd14226 PKc_DYRK1 cd14211 STKc_HIPK cd14227 STKc_HIPK2 cd14228 STKc_HIPK1 cd14229 STKc_HIPK3 cd14212 PKc_YAK1 cd14134 PKc_CLK cd14213 PKc_CLK1_4 cd14214 PKc_CLK3 cd14215 PKc_CLK2 cd14135 STKc_PRP4 cd14136 STKc_SRPK cd14216 STKc_SRPK1 cd14217 STKc_SRPK2 cd14218 STKc_SRPK3 cd14137 STKc_GSK3 cd05122 PKc_STE cd06605 PKc_MAPKK cd06615 PKc_MEK cd06649 PKc_MEK2 cd06650 PKc_MEK1 cd06616 PKc_MKK4 cd06617 PKc_MKK3_6 cd06618 PKc_MKK7 cd06619 PKc_MKK5 cd06620 PKc_Byr1_like cd06621 PKc_Pek1_like cd06622 PKc_PBS2_like cd06623 PKc_MAPKK_plant_like cd06606 STKc_MAPKKK cd06624 STKc_ASK cd06625 STKc_MEKK3_like cd06651 STKc_MEKK3 cd06652 STKc_MEKK2 cd06653 STKc_MEKK3_like_u1 cd06626 STKc_MEKK4 cd06627 STKc_Cdc7_like cd06628 STKc_Byr2_like cd06629 STKc_Bck1_like cd06630 STKc_MEKK1 cd06631 STKc_YSK4 cd06632 STKc_MEKK1_plant cd06607 STKc_TAO cd06633 STKc_TAO3 cd06634 STKc_TAO2 cd06635 STKc_TAO1 cd06608 STKc_myosinIII_N_like cd06636 STKc_MAP4K4_6_N cd06637 STKc_TNIK cd06638 STKc_myosinIIIA_N cd06639 STKc_myosinIIIB_N cd06609 STKc_MST3_like cd06640 STKc_MST4 cd06641 STKc_MST3 cd06642 STKc_STK25 cd06917 STKc_NAK1_like cd06610 STKc_OSR1_SPAK cd06611 STKc_SLK_like cd06643 STKc_SLK cd06644 STKc_STK10 cd06612 STKc_MST1_2 cd06613 STKc_MAP4K3_like cd06645 STKc_MAP4K3 cd06646 STKc_MAP4K5 cd06614 STKc_PAK cd06647 STKc_PAK_I cd06654 STKc_PAK1 cd06655 STKc_PAK2 cd06656 STKc_PAK3 cd06648 STKc_PAK_II cd06657 STKc_PAK4 cd06658 STKc_PAK5 cd06659 STKc_PAK6 cd14131 PKc_Mps1 cd05123 STKc_AGC cd05570 STKc_PKC cd05587 STKc_cPKC cd05615 STKc_cPKC_alpha cd05616 STKc_cPKC_beta cd05588 STKc_aPKC cd05617 STKc_aPKC_zeta cd05618 STKc_aPKC_iota cd05589 STKc_PKN cd05590 STKc_nPKC_eta cd05591 STKc_nPKC_epsilon cd05592 STKc_nPKC_theta_like cd05619 STKc_nPKC_theta cd05620 STKc_nPKC_delta cd05571 STKc_PKB cd05593 STKc_PKB_gamma cd05594 STKc_PKB_alpha cd05595 STKc_PKB_beta cd05572 STKc_cGK cd05573 STKc_ROCK_NDR_like cd05596 STKc_ROCK cd05621 STKc_ROCK2 cd05622 STKc_ROCK1 cd05597 STKc_DMPK_like cd05623 STKc_MRCK_alpha cd05624 STKc_MRCK_beta cd05598 STKc_LATS cd05625 STKc_LATS1 cd05626 STKc_LATS2 cd05599 STKc_NDR_like cd05627 STKc_NDR2 cd05628 STKc_NDR1 cd05629 STKc_NDR_like_fungal cd05600 STKc_Sid2p_like cd05601 STKc_CRIK cd05574 STKc_phototropin_like cd05575 STKc_SGK cd05602 STKc_SGK1 cd05603 STKc_SGK2 cd05604 STKc_SGK3 cd05576 STKc_RPK118_like cd05577 STKc_GRK cd05605 STKc_GRK4_like cd05630 STKc_GRK6 cd05631 STKc_GRK4 cd05632 STKc_GRK5 cd05606 STKc_beta_ARK cd05633 STKc_GRK3 cd14223 STKc_GRK2 cd05607 STKc_GRK7 cd05608 STKc_GRK1 cd05578 STKc_Yank1 cd05579 STKc_MAST_like cd05609 STKc_MAST cd05610 STKc_MASTL cd05611 STKc_Rim15_like cd05580 STKc_PKA_like cd05612 STKc_PRKX_like cd14209 STKc_PKA cd05581 STKc_PDK1 cd05582 STKc_RSK_N cd05583 STKc_MSK_N cd05613 STKc_MSK1_N cd05614 STKc_MSK2_N cd05584 STKc_p70S6K cd05585 STKc_YPK1_like cd05586 STKc_Sck1_like cd08215 STKc_Nek cd08217 STKc_Nek2 cd08218 STKc_Nek1 cd08219 STKc_Nek3 cd08220 STKc_Nek8 cd08221 STKc_Nek9 cd08222 STKc_Nek11 cd08223 STKc_Nek4 cd08224 STKc_Nek6_7 cd08228 STKc_Nek6 cd08229 STKc_Nek7 cd08225 STKc_Nek5 cd08528 STKc_Nek10 cd08529 STKc_FA2-like cd08530 STKc_CNK2-like cd08216 PK_STRAD cd08226 PK_STRAD_beta cd08227 PK_STRAD_alpha cd13973 PK_MviN-like cd13974 STKc_SHIK cd13975 PKc_Dusty cd13976 PK_TRB cd14022 PK_TRB2 cd14023 PK_TRB1 cd14024 PK_TRB3 cd13977 STKc_PDIK1L cd13978 STKc_RIP cd14025 STKc_RIP4_like cd14026 STKc_RIP2 cd14027 STKc_RIP1 cd13979 STKc_Mos cd13980 STKc_Vps15 cd13981 STKc_Bub1_BubR1 cd14028 STKc_Bub1_vert cd14029 STKc_BubR1_vert cd13982 STKc_IRE1 cd13983 STKc_WNK cd14030 STKc_WNK1 cd14031 STKc_WNK3 cd14032 STKc_WNK2_like cd14033 STKc_WNK4 cd13984 PK_NRBP1_like cd14034 PK_NRBP1 cd14035 PK_MADML cd13985 STKc_GAK_like cd14036 STKc_GAK cd14037 STKc_NAK_like cd13986 STKc_16 cd13987 STKc_SBK1 cd13988 STKc_TBK1 cd13989 STKc_IKK cd14038 STKc_IKK_beta cd14039 STKc_IKK_alpha cd13990 STKc_TLK cd14040 STKc_TLK1 cd14041 STKc_TLK2 cd13991 STKc_NIK cd13992 PK_GC cd14042 PK_GC-A_B cd14043 PK_GC-2D cd14044 PK_GC-C cd14045 PK_GC_unk cd13993 STKc_Pat1_like cd13994 STKc_HAL4_like cd13995 STKc_MAP3K8 cd13996 STKc_EIF2AK cd14046 STKc_EIF2AK4_GCN2_rpt2 cd14047 STKc_EIF2AK2_PKR cd14048 STKc_EIF2AK3_PERK cd14049 STKc_EIF2AK1_HRI cd13997 PKc_Wee1_like cd14050 PKc_Myt1 cd14051 PTKc_Wee1 cd14138 PTKc_Wee1a cd14139 PTKc_Wee1b cd14052 PTKc_Wee1_fungi cd13998 STKc_TGFbR-like cd14053 STKc_ACVR2 cd14140 STKc_ACVR2b cd14141 STKc_ACVR2a cd14054 STKc_BMPR2_AMHR2 cd14055 STKc_TGFbR2_like cd14056 STKc_TGFbR_I cd14142 STKc_ACVR1_ALK1 cd14143 STKc_TGFbR1_ACVR1b_ACVR1c cd14144 STKc_BMPR1 cd14219 STKc_BMPR1b cd14220 STKc_BMPR1a cd13999 STKc_MAP3K-like cd14057 PK_ILK cd14058 STKc_TAK1 cd14059 STKc_MAP3K12_13 cd14060 STKc_MLTK cd14061 STKc_MLK cd14145 STKc_MLK1 cd14146 STKc_MLK4 cd14147 STKc_MLK3 cd14148 STKc_MLK2 cd14062 STKc_Raf cd14149 STKc_C-Raf cd14150 STKc_A-Raf cd14151 STKc_B-Raf cd14063 PK_KSR cd14152 STKc_KSR1 cd14153 PK_KSR2 cd14064 PKc_TNNI3K cd14065 PKc_LIMK_like cd14154 STKc_LIMK cd14221 STKc_LIMK1 cd14222 STKc_LIMK2 cd14155 PKc_TESK cd14156 PKc_LIMK_like_unk cd14066 STKc_IRAK cd14157 STKc_IRAK2 cd14158 STKc_IRAK4 cd14159 STKc_IRAK1 cd14160 PK_IRAK3 cd14664 STK_BAK1_like cd14000 STKc_LRRK cd14067 STKc_LRRK1 cd14068 STKc_LRRK2 cd14001 PKc_TOPK cd14002 STKc_STK36 cd14003 STKc_AMPK-like cd14069 STKc_Chk1 cd14070 STKc_HUNK cd14071 STKc_SIK cd14072 STKc_MARK cd14073 STKc_NUAK cd14161 STKc_NUAK2 cd14074 STKc_SNRK cd14075 STKc_NIM1 cd14076 STKc_Kin4 cd14077 STKc_Kin1_2 cd14078 STKc_MELK cd14079 STKc_AMPK_alpha cd14080 STKc_TSSK-like cd14162 STKc_TSSK4-like cd14163 STKc_TSSK3-like cd14164 STKc_TSSK6-like cd14165 STKc_TSSK1_2-like cd14081 STKc_BRSK1_2 cd14662 STKc_SnRK2 cd14665 STKc_SnRK2-3 cd14663 STKc_SnRK3 cd14004 STKc_PASK cd14005 STKc_PIM cd14100 STKc_PIM1 cd14101 STKc_PIM2 cd14102 STKc_PIM3 cd14006 STKc_MLCK-like cd14103 STKc_MLCK cd14190 STKc_MLCK2 cd14191 STKc_MLCK1 cd14192 STKc_MLCK3 cd14193 STKc_MLCK4 cd14104 STKc_Titin cd14105 STKc_DAPK cd14194 STKc_DAPK1 cd14195 STKc_DAPK3 cd14196 STKc_DAPK2 cd14106 STKc_DRAK cd14197 STKc_DRAK1 cd14198 STKc_DRAK2 cd14107 STKc_obscurin_rpt1 cd14108 STKc_SPEG_rpt1 cd14109 PK_Unc-89_rpt1 cd14110 STKc_obscurin_rpt2 cd14111 STKc_SPEG_rpt2 cd14112 STKc_Unc-89_rpt2 cd14113 STKc_Trio_C cd14114 STKc_Twitchin_like cd14115 STKc_Kalirin_C cd14007 STKc_Aurora cd14116 STKc_Aurora-A cd14117 STKc_Aurora-B_like cd14008 STKc_LKB1_CaMKK cd14118 STKc_CAMKK cd14199 STKc_CaMKK2 cd14200 STKc_CaMKK1 cd14119 STKc_LKB1 cd14009 STKc_ATG1_ULK_like cd14120 STKc_ULK1_2-like cd14201 STKc_ULK2 cd14202 STKc_ULK1 cd14121 STKc_ULK3 cd14010 STKc_ULK4 cd14011 PK_SCY1_like cd14012 PK_eIF2AK_GCN2_rpt1 cd14013 STKc_SNT7_plant cd14014 STKc_PknB_like cd14015 STKc_VRK cd14122 STKc_VRK1 cd14123 STKc_VRK2 cd14124 PK_VRK3 cd14016 STKc_CK1 cd14125 STKc_CK1_delta_epsilon cd14126 STKc_CK1_gamma cd14127 STKc_CK1_fungal cd14128 STKc_CK1_alpha cd14017 STKc_TTBK cd14129 STKc_TTBK2 cd14130 STKc_TTBK1 cd14018 STKc_PINK1 cd14019 STKc_Cdc7 cd14020 STKc_KIS cd14099 STKc_PLK cd14186 STKc_PLK4 cd14187 STKc_PLK1 cd14188 STKc_PLK2 cd14189 STKc_PLK3 cd05119 RIO cd05144 RIO2_C cd05145 RIO1_like cd05146 RIO3_euk cd05147 RIO1_euk cd05120 APH_ChoK_like cd05150 APH cd05151 ChoK-like cd14021 ChoK-like_euk cd05156 ChoK_euk cd05157 ETNK_euk cd05152 MPH2' cd05153 HomoserineK_II cd05154 ACAD10_11_N-like cd05155 APH_ChoK_like_1 cd05121 ABC1_ADCK3-like cd13969 ADCK1-like cd13970 ABC1_ADCK3 cd13971 ADCK2-like cd13972 UbiB cd05124 AFK