Conserved Protein Domain Family
PTKc_Kit

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cd05104: PTKc_Kit 
Catalytic domain of the Protein Tyrosine Kinase, Kit
PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Kit is important in the development of melanocytes, germ cells, mast cells, hematopoietic stem cells, the interstitial cells of Cajal, and the pacemaker cells of the GI tract. Kit signaling is involved in major cellular functions including cell survival, proliferation, differentiation, adhesion, and chemotaxis. Mutations in Kit, which result in constitutive ligand-independent activation, are found in human cancers such as gastrointestinal stromal tumor (GIST) and testicular germ cell tumor (TGCT). The aberrant expression of Kit and/or SCF is associated with other tumor types such as systemic mastocytosis and cancers of the breast, neurons, lung, prostate, colon, and rectum. Although the structure of the human Kit catalytic domain is known, it is excluded from this specific alignment model because it contains a deletion in its sequence. Kit is a member of the Platelet Derived Growth Factor Receptor (PDGFR) subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with five immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of Kit to its ligand, the stem-cell factor (SCF), leads to receptor dimerization, trans phosphorylation and activation, and intracellular signaling. The Kit subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 270682
Aligned: 5 rows
Threshold Bit Score: 771.766
Created: 16-Mar-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:includes ATP binding and substrate binding sites
  • Comment:Based on the structures of other PTK family members bound to substrate peptides and ATP analogs, as well as the structure of human c-Kit bound to MgADP.
  • Citation:PMID 9312016

cd05104 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd05104 is a member of the superfamily cl21453
Sub-family Hierarchy
cd13968PKc_likecd00142PI3Kc_likecd00891PI3Kccd00896PI3Kc_IIIcd05165PI3Kc_Icd00894PI3Kc_IB_gammacd05173PI3Kc_IA_betacd05174PI3Kc_IA_deltacd05175PI3Kc_IA_alphacd05166PI3Kc_IIcd00895PI3Kc_C2_betacd05176PI3Kc_C2_alphacd05177PI3Kc_C2_gammacd00893PI4Kc_IIIcd05167PI4Kc_III_alphacd05168PI4Kc_III_betacd05164PIKKccd00892PIKKc_ATRcd05163PIKK_TRRAPcd05169PIKKc_TORcd05170PIKKc_SMG1cd05171PIKKc_ATMcd05172PIKKc_DNA-PKcd00180PKccd00192PTKccd05032PTKc_InsR_likecd05061PTKc_InsRcd05062PTKc_IGF-1Rcd05033PTKc_EphRcd05063PTKc_EphR_A2cd05064PTKc_EphR_A10cd05065PTKc_EphR_Bcd05066PTKc_EphR_Acd05034PTKc_Src_likecd05067PTKc_Lck_Blkcd05068PTKc_Frk_likecd05072PTKc_Lyncd05073PTKc_Hckcd05148PTKc_Srm_Brkcd14203PTKc_Src_Fyn_likecd05069PTKc_Yescd05070PTKc_Fyncd05071PTKc_Srccd05035PTKc_TAMcd05074PTKc_Tyro3cd05075PTKc_Axlcd14204PTKc_Mercd05036PTKc_ALK_LTKcd05038PTKc_Jak_rpt2cd05079PTKc_Jak1_rpt2cd05080PTKc_Tyk2_rpt2cd05081PTKc_Jak3_rpt2cd14205PTKc_Jak2_rpt2cd05039PTKc_Csk_likecd05082PTKc_Cskcd05083PTKc_Chkcd05040PTKc_Ack_likecd05041PTKc_Fes_likecd05084PTKc_Fescd05085PTKc_Fercd05042PTKc_Aatykcd05086PTKc_Aatyk2cd05087PTKc_Aatyk1cd14206PTKc_Aatyk3cd05043PTK_Rykcd05044PTKc_c-roscd05045PTKc_RETcd05046PTK_CCK4cd05047PTKc_Tiecd05088PTKc_Tie2cd05089PTKc_Tie1cd05048PTKc_Rorcd05090PTKc_Ror1cd05091PTKc_Ror2cd05049PTKc_Trkcd05092PTKc_TrkAcd05093PTKc_TrkBcd05094PTKc_TrkCcd05050PTKc_Muskcd05051PTKc_DDRcd05095PTKc_DDR2cd05096PTKc_DDR1cd05097PTKc_DDR_likecd05052PTKc_Ablcd05053PTKc_FGFRcd05098PTKc_FGFR1cd05099PTKc_FGFR4cd05100PTKc_FGFR3cd05101PTKc_FGFR2cd05054PTKc_VEGFRcd05102PTKc_VEGFR3cd05103PTKc_VEGFR2cd14207PTKc_VEGFR1cd05055PTKc_PDGFRcd05104PTKc_Kitcd05105PTKc_PDGFR_alphacd05106PTKc_CSF-1Rcd05107PTKc_PDGFR_betacd05056PTKc_FAKcd05057PTKc_EGFR_likecd05108PTKc_EGFRcd05109PTKc_HER2cd05110PTKc_HER4cd05111PTK_HER3cd05058PTKc_Met_Roncd05059PTKc_Tec_likecd05112PTKc_Itkcd05113PTKc_Btk_Bmxcd05114PTKc_Tec_Rlkcd05060PTKc_Syk_likecd05115PTKc_Zap-70cd05116PTKc_Sykcd05037PTK_Jak_rpt1cd05076PTK_Tyk2_rpt1cd05077PTK_Jak1_rpt1cd05078PTK_Jak2_rpt1cd14208PTK_Jak3_rpt1cd05117STKc_CAMKcd14082STKc_PKDcd14083STKc_CaMKIcd14166STKc_CaMKI_gammacd14167STKc_CaMKI_alphacd14168STKc_CaMKI_deltacd14169STKc_CaMKI_betacd14084STKc_Chk2cd14085STKc_CaMKIVcd14086STKc_CaMKIIcd14087STKc_PSKH1cd14088STKc_CaMK_likecd14089STKc_MAPKAPKcd14170STKc_MAPKAPK2cd14171STKc_MAPKAPK5cd14172STKc_MAPKAPK3cd14090STKc_Mnkcd14173STKc_Mnk2cd14174STKc_Mnk1cd14091STKc_RSK_Ccd14175STKc_RSK1_Ccd14176STKc_RSK2_Ccd14177STKc_RSK4_Ccd14178STKc_RSK3_Ccd14092STKc_MSK_Ccd14179STKc_MSK1_Ccd14180STKc_MSK2_Ccd14093STKc_PhKGcd14181STKc_PhKG2cd14182STKc_PhKG1cd14094STKc_CASKcd14095STKc_DCKLcd14183STKc_DCKL1cd14184STKc_DCKL2cd14185STKc_DCKL3cd14096STKc_RCK1-likecd14097STKc_STK33cd14098STKc_Rad53_Cds1cd05118STKc_CMGCcd07829STKc_CDK_likecd07835STKc_CDK1_CdkB_likecd07837STKc_CdkB_plantcd07860STKc_CDK2_3cd07861STKc_CDK1_eukcd07836STKc_Pho85cd07838STKc_CDK4_6_likecd07862STKc_CDK6cd07863STKc_CDK4cd07839STKc_CDK5cd07840STKc_CDK9_likecd07864STKc_CDK12cd07865STKc_CDK9cd07866STKc_BUR1cd07841STKc_CDK7cd07842STKc_CDK8_likecd07867STKc_CDC2L6cd07868STKc_CDK8cd07843STKc_CDC2L1cd07844STKc_PCTAIRE_likecd07869STKc_PFTAIRE1cd07870STKc_PFTAIRE2cd07871STKc_PCTAIRE3cd07872STKc_PCTAIRE2cd07873STKc_PCTAIRE1cd07845STKc_CDK10cd07830STKc_MAK_likecd07831STKc_MOKcd07832STKc_CCRKcd07833STKc_CDKLcd07846STKc_CDKL2_3cd07847STKc_CDKL1_4cd07848STKc_CDKL5cd07834STKc_MAPKcd07849STKc_ERK1_2_likecd07850STKc_JNKcd07874STKc_JNK3cd07875STKc_JNK1cd07876STKc_JNK2cd07851STKc_p38cd07877STKc_p38alphacd07878STKc_p38betacd07879STKc_p38deltacd07880STKc_p38gammacd07852STKc_MAPK15-likecd07853STKc_NLKcd07854STKc_MAPK4_6cd07855STKc_ERK5cd07856STKc_Sty1_Hog1cd07857STKc_MPK1cd07858STKc_TEY_MAPKcd07859STKc_TDY_MAPKcd14132STKc_CK2_alphacd14133PKc_DYRK_likecd14210PKc_DYRKcd14224PKc_DYRK2_3cd14225PKc_DYRK4cd14226PKc_DYRK1cd14211STKc_HIPKcd14227STKc_HIPK2cd14228STKc_HIPK1cd14229STKc_HIPK3cd14212PKc_YAK1cd14134PKc_CLKcd14213PKc_CLK1_4cd14214PKc_CLK3cd14215PKc_CLK2cd14135STKc_PRP4cd14136STKc_SRPKcd14216STKc_SRPK1cd14217STKc_SRPK2cd14218STKc_SRPK3cd14137STKc_GSK3cd05122PKc_STEcd06605PKc_MAPKKcd06615PKc_MEKcd06649PKc_MEK2cd06650PKc_MEK1cd06616PKc_MKK4cd06617PKc_MKK3_6cd06618PKc_MKK7cd06619PKc_MKK5cd06620PKc_Byr1_likecd06621PKc_Pek1_likecd06622PKc_PBS2_likecd06623PKc_MAPKK_plant_likecd06606STKc_MAPKKKcd06624STKc_ASKcd06625STKc_MEKK3_likecd06651STKc_MEKK3cd06652STKc_MEKK2cd06653STKc_MEKK3_like_u1cd06626STKc_MEKK4cd06627STKc_Cdc7_likecd06628STKc_Byr2_likecd06629STKc_Bck1_likecd06630STKc_MEKK1cd06631STKc_YSK4cd06632STKc_MEKK1_plantcd06607STKc_TAOcd06633STKc_TAO3cd06634STKc_TAO2cd06635STKc_TAO1cd06608STKc_myosinIII_N_likecd06636STKc_MAP4K4_6_Ncd06637STKc_TNIKcd06638STKc_myosinIIIA_Ncd06639STKc_myosinIIIB_Ncd06609STKc_MST3_likecd06640STKc_MST4cd06641STKc_MST3cd06642STKc_STK25cd06917STKc_NAK1_likecd06610STKc_OSR1_SPAKcd06611STKc_SLK_likecd06643STKc_SLKcd06644STKc_STK10cd06612STKc_MST1_2cd06613STKc_MAP4K3_likecd06645STKc_MAP4K3cd06646STKc_MAP4K5cd06614STKc_PAKcd06647STKc_PAK_Icd06654STKc_PAK1cd06655STKc_PAK2cd06656STKc_PAK3cd06648STKc_PAK_IIcd06657STKc_PAK4cd06658STKc_PAK5cd06659STKc_PAK6cd14131PKc_Mps1cd05123STKc_AGCcd05570STKc_PKCcd05587STKc_cPKCcd05615STKc_cPKC_alphacd05616STKc_cPKC_betacd05588STKc_aPKCcd05617STKc_aPKC_zetacd05618STKc_aPKC_iotacd05589STKc_PKNcd05590STKc_nPKC_etacd05591STKc_nPKC_epsiloncd05592STKc_nPKC_theta_likecd05619STKc_nPKC_thetacd05620STKc_nPKC_deltacd05571STKc_PKBcd05593STKc_PKB_gammacd05594STKc_PKB_alphacd05595STKc_PKB_betacd05572STKc_cGKcd05573STKc_ROCK_NDR_likecd05596STKc_ROCKcd05621STKc_ROCK2cd05622STKc_ROCK1cd05597STKc_DMPK_likecd05623STKc_MRCK_alphacd05624STKc_MRCK_betacd05598STKc_LATScd05625STKc_LATS1cd05626STKc_LATS2cd05599STKc_NDR_likecd05627STKc_NDR2cd05628STKc_NDR1cd05629STKc_NDR_like_fungalcd05600STKc_Sid2p_likecd05601STKc_CRIKcd05574STKc_phototropin_likecd05575STKc_SGKcd05602STKc_SGK1cd05603STKc_SGK2cd05604STKc_SGK3cd05576STKc_RPK118_likecd05577STKc_GRKcd05605STKc_GRK4_likecd05630STKc_GRK6cd05631STKc_GRK4cd05632STKc_GRK5cd05606STKc_beta_ARKcd05633STKc_GRK3cd14223STKc_GRK2cd05607STKc_GRK7cd05608STKc_GRK1cd05578STKc_Yank1cd05579STKc_MAST_likecd05609STKc_MASTcd05610STKc_MASTLcd05611STKc_Rim15_likecd05580STKc_PKA_likecd05612STKc_PRKX_likecd14209STKc_PKAcd05581STKc_PDK1cd05582STKc_RSK_Ncd05583STKc_MSK_Ncd05613STKc_MSK1_Ncd05614STKc_MSK2_Ncd05584STKc_p70S6Kcd05585STKc_YPK1_likecd05586STKc_Sck1_likecd08215STKc_Nekcd08217STKc_Nek2cd08218STKc_Nek1cd08219STKc_Nek3cd08220STKc_Nek8cd08221STKc_Nek9cd08222STKc_Nek11cd08223STKc_Nek4cd08224STKc_Nek6_7cd08228STKc_Nek6cd08229STKc_Nek7cd08225STKc_Nek5cd08528STKc_Nek10cd08529STKc_FA2-likecd08530STKc_CNK2-likecd08216PK_STRADcd08226PK_STRAD_betacd08227PK_STRAD_alphacd13973PK_MviN-likecd13974STKc_SHIKcd13975PKc_Dustycd13976PK_TRBcd14022PK_TRB2cd14023PK_TRB1cd14024PK_TRB3cd13977STKc_PDIK1Lcd13978STKc_RIPcd14025STKc_RIP4_likecd14026STKc_RIP2cd14027STKc_RIP1cd13979STKc_Moscd13980STKc_Vps15cd13981STKc_Bub1_BubR1cd14028STKc_Bub1_vertcd14029STKc_BubR1_vertcd13982STKc_IRE1cd13983STKc_WNKcd14030STKc_WNK1cd14031STKc_WNK3cd14032STKc_WNK2_likecd14033STKc_WNK4cd13984PK_NRBP1_likecd14034PK_NRBP1cd14035PK_MADMLcd13985STKc_GAK_likecd14036STKc_GAKcd14037STKc_NAK_likecd13986STKc_16cd13987STKc_SBK1cd13988STKc_TBK1cd13989STKc_IKKcd14038STKc_IKK_betacd14039STKc_IKK_alphacd13990STKc_TLKcd14040STKc_TLK1cd14041STKc_TLK2cd13991STKc_NIKcd13992PK_GCcd14042PK_GC-A_Bcd14043PK_GC-2Dcd14044PK_GC-Ccd14045PK_GC_unkcd13993STKc_Pat1_likecd13994STKc_HAL4_likecd13995STKc_MAP3K8cd13996STKc_EIF2AKcd14046STKc_EIF2AK4_GCN2_rpt2cd14047STKc_EIF2AK2_PKRcd14048STKc_EIF2AK3_PERKcd14049STKc_EIF2AK1_HRIcd13997PKc_Wee1_likecd14050PKc_Myt1cd14051PTKc_Wee1cd14138PTKc_Wee1acd14139PTKc_Wee1bcd14052PTKc_Wee1_fungicd13998STKc_TGFbR-likecd14053STKc_ACVR2cd14140STKc_ACVR2bcd14141STKc_ACVR2acd14054STKc_BMPR2_AMHR2cd14055STKc_TGFbR2_likecd14056STKc_TGFbR_Icd14142STKc_ACVR1_ALK1cd14143STKc_TGFbR1_ACVR1b_ACVR1ccd14144STKc_BMPR1cd14219STKc_BMPR1bcd14220STKc_BMPR1acd13999STKc_MAP3K-likecd14057PK_ILKcd14058STKc_TAK1cd14059STKc_MAP3K12_13cd14060STKc_MLTKcd14061STKc_MLKcd14145STKc_MLK1cd14146STKc_MLK4cd14147STKc_MLK3cd14148STKc_MLK2cd14062STKc_Rafcd14149STKc_C-Rafcd14150STKc_A-Rafcd14151STKc_B-Rafcd14063PK_KSRcd14152STKc_KSR1cd14153PK_KSR2cd14064PKc_TNNI3Kcd14065PKc_LIMK_likecd14154STKc_LIMKcd14221STKc_LIMK1cd14222STKc_LIMK2cd14155PKc_TESKcd14156PKc_LIMK_like_unkcd14066STKc_IRAKcd14157STKc_IRAK2cd14158STKc_IRAK4cd14159STKc_IRAK1cd14160PK_IRAK3cd14664STK_BAK1_likecd14000STKc_LRRKcd14067STKc_LRRK1cd14068STKc_LRRK2cd14001PKc_TOPKcd14002STKc_STK36cd14003STKc_AMPK-likecd14069STKc_Chk1cd14070STKc_HUNKcd14071STKc_SIKcd14072STKc_MARKcd14073STKc_NUAKcd14161STKc_NUAK2cd14074STKc_SNRKcd14075STKc_NIM1cd14076STKc_Kin4cd14077STKc_Kin1_2cd14078STKc_MELKcd14079STKc_AMPK_alphacd14080STKc_TSSK-likecd14162STKc_TSSK4-likecd14163STKc_TSSK3-likecd14164STKc_TSSK6-likecd14165STKc_TSSK1_2-likecd14081STKc_BRSK1_2cd14662STKc_SnRK2cd14665STKc_SnRK2-3cd14663STKc_SnRK3cd14004STKc_PASKcd14005STKc_PIMcd14100STKc_PIM1cd14101STKc_PIM2cd14102STKc_PIM3cd14006STKc_MLCK-likecd14103STKc_MLCKcd14190STKc_MLCK2cd14191STKc_MLCK1cd14192STKc_MLCK3cd14193STKc_MLCK4cd14104STKc_Titincd14105STKc_DAPKcd14194STKc_DAPK1cd14195STKc_DAPK3cd14196STKc_DAPK2cd14106STKc_DRAKcd14197STKc_DRAK1cd14198STKc_DRAK2cd14107STKc_obscurin_rpt1cd14108STKc_SPEG_rpt1cd14109PK_Unc-89_rpt1cd14110STKc_obscurin_rpt2cd14111STKc_SPEG_rpt2cd14112STKc_Unc-89_rpt2cd14113STKc_Trio_Ccd14114STKc_Twitchin_likecd14115STKc_Kalirin_Ccd14007STKc_Auroracd14116STKc_Aurora-Acd14117STKc_Aurora-B_likecd14008STKc_LKB1_CaMKKcd14118STKc_CAMKKcd14199STKc_CaMKK2cd14200STKc_CaMKK1cd14119STKc_LKB1cd14009STKc_ATG1_ULK_likecd14120STKc_ULK1_2-likecd14201STKc_ULK2cd14202STKc_ULK1cd14121STKc_ULK3cd14010STKc_ULK4cd14011PK_SCY1_likecd14012PK_eIF2AK_GCN2_rpt1cd14013STKc_SNT7_plantcd14014STKc_PknB_likecd14015STKc_VRKcd14122STKc_VRK1cd14123STKc_VRK2cd14124PK_VRK3cd14016STKc_CK1cd14125STKc_CK1_delta_epsiloncd14126STKc_CK1_gammacd14127STKc_CK1_fungalcd14128STKc_CK1_alphacd14017STKc_TTBKcd14129STKc_TTBK2cd14130STKc_TTBK1cd14018STKc_PINK1cd14019STKc_Cdc7cd14020STKc_KIScd14099STKc_PLKcd14186STKc_PLK4cd14187STKc_PLK1cd14188STKc_PLK2cd14189STKc_PLK3cd05119RIOcd05144RIO2_Ccd05145RIO1_likecd05146RIO3_eukcd05147RIO1_eukcd05120APH_ChoK_likecd05150APHcd05151ChoK-likecd14021ChoK-like_eukcd05156ChoK_eukcd05157ETNK_eukcd05152MPH2'cd05153HomoserineK_IIcd05154ACAD10_11_N-likecd05155APH_ChoK_like_1cd05121ABC1_ADCK3-likecd13969ADCK1-likecd13970ABC1_ADCK3cd13971ADCK2-likecd13972UbiBcd05124AFK
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                               ####### #                 # #         
AAC50969  549 YEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHlt 628  human
Q08156    539 YEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLFKSDAAMTVAVKMLKPSAHlt 618  chicken
Q8JFR5    544 YQIQWKVIEGIHGNNYVYIDPTQLPYDHQWEFPRDKLRFGKTLGSGAFGKVVEATAYGMSKADTVMTVAVKMLKPSAHat 623  zebrafish
Q91909    541 YEIQWKVVEEINGNNYVYIDPTQLPYDNKWEFPRDRLCFGKILGAGAFGKVVEATAYGLLKEDSRLTVAVKMLKPSAHst 620  African clawed frog
CAG10970  586 YQIQWKVIEGIHGNNYVYIDPTQLPYDHQWEFPRKNLRFGKTLGSGAFGKVVEATAYGLASADSTMTVAVKMLKSSAHst 665  Tetraodon nigrovi...
Feature 1                                           # #   #                                   
AAC50969  629 EREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICskqEDHAEAALYKNLLHSKES 708  human
Q08156    619 EREALMSELKVLSYLGNHINIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICpkhEEHAEAAVYENLLHQAEP 698  chicken
Q8JFR5    624 EKEALMSELKVLSYLGNHINIVNLLGACTVGGPTLVITEYCCFGDLLNFLRRRRVYFYY---TTLGEDAYYRNVMMQSEP 700  zebrafish
Q91909    621 EREALMSELKVLSYLGHHKNIVNLLGACTVGGPTLVITEYCCYGDLLNYLRRKRDSFICpkfEDNSEAALYKNLLNTRDM 700  African clawed frog
CAG10970  666 EKEALMSELKVLIYLGNHINIVNLLGACTVGGPTLVITEYCCFGDLLNFLRRKRESFIC---FKLEEDCHYRNVMLQREM 742  Tetraodon nigrovi...
Feature 1                                                                                     
AAC50969  709 ScsDSTNEYMDMKPG------VSYVVPTKADKRrs---vRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFL 779  human
Q08156    699 Ta-DAVNEYMDMKPG------VSYAVPPKADKKrp---vKSGSYTDQDVTLSMLEDDELALDVEDLLSFSYQVAKGMSFL 768  chicken
Q8JFR5    701 N--DSRNGYMTMKPS------VLGILSSENRRSl----nKGDSYSDSDAVSEILQEDGLTLDTEDLLSFSYQVAKGMDFL 768  zebrafish
Q91909    701 Gc-EGMSEYIDMKPA------VSYVVPTKTDKR------RSGSFGDQDVSVSIPEEDDLALDTEDLINFSYQVAQGMNFL 767  African clawed frog
CAG10970  743 Ag-DSLNGYMTMRPSaagtlsPSFSSEKKRSLRkgkhasHCSQYVEADSESEMFDEDSLSLDTEDLLSFSYQVAKGMEFL 821  Tetraodon nigrovi...
Feature 1             #   ## #          #                 #####        #                      
AAC50969  780 ASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELF 859  human
Q08156    769 ASKNCIHRDLAARNILLTHGRITKICDFGLARDIRNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGILLWELF 848  chicken
Q8JFR5    769 ASKNCIHRDLAARNILLTQGRVAKICDFGLARDITTDSNYVVKGNARLPVKWMSPESIFECVYTFESDVWSYGILLWEIF 848  zebrafish
Q91909    768 ASKNCIHRDLAARNILLTHGRITKICDFGLARDIRNDSNYVVKGNARLPVKWMAPESIFHCVYTFESDVWSYGILLWEIF 847  African clawed frog
CAG10970  822 TSKNCIHRDLAARNILLTQGRVAKICDFGLARDINTDSNYVVKGNARLPVKWMSPESIFECVYTFESDVWSYGILLWEIF 901  Tetraodon nigrovi...
Feature 1                 #                                                    
AAC50969  860 SLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQI 924  human
Q08156    849 SLGSSPYPGMPVDSKFYKMIKEGYRMFSPECSPPEMYDIMKSCWDADPLQRPTFKQIVQLIEQQL 913  chicken
Q8JFR5    849 SLGSSPYPGMPVDSKFYKMIKEGYRMESPEFSPSEMYDIMHSCWDADPVKRPSFSKIVEKIEQQI 913  zebrafish
Q91909    848 SLGSSPYPRIPVDSKFYKMIKDGYRMMSPECAPLEMYEIMRSCWNSDPLKRPTFKQIVQMVEQQL 912  African clawed frog
CAG10970  902 SLGNSPYPGMPVDAKFYKLIKEGYRMDAPEFAPSEMYQIMRSCWDADPLNRPPFRKVVERIEQQL 966  Tetraodon nigroviridis

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