Conserved Protein Domain Family
PTKc_DDR1

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cd05096: PTKc_DDR1 
Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. DDR1 is a receptor PTK (RTK) containing an extracellular discoidin homology domain, a transmembrane segment, an extended juxtamembrane region, and an intracellular catalytic domain. The binding of the ligand, collagen, to DDR1 results in a slow but sustained receptor activation. DDR1 binds to all collagens tested to date (types I-IV). It is widely expressed in many tissues. It is abundant in the brain and is also found in keratinocytes, colonic mucosa epithelium, lung epithelium, thyroid follicles, and the islets of Langerhans. During embryonic development, it is found in the developing neuroectoderm. DDR1 is a key regulator of cell morphogenesis, differentiation and proliferation. It is important in the development of the mammary gland, the vasculator and the kidney. DDR1 is also found in human leukocytes, where it facilitates cell adhesion, migration, maturation, and cytokine production. The DDR1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 133227
View PSSM: cd05096
Aligned: 3 rows
Threshold Bit Score: 621.954
Threshold Setting Gi: 47221550
Created: 9-Jul-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:includes ATP binding and substrate binding sites
  • Comment:Based on the structures of other PTK family members bound to substrate peptides and ATP analogs.
  • Citation:PMID 9312016

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                  #####   #                            # #                            
AAH70070   567 DFPRSRLRFKEKLGEGQFGEVHLCEVDSPqdlvsldFPLNVRKGHPLLVAVKILRPDAtknaRNDFLKEVKIMSRLKDPN 646  human
AAH60755   636 KFPRGHLLFREKLGEGQFGEVHLCEVVNPhelptlqFPFNMRKGRSLLVAVKLLRADAnknaRSDFLKELKILSRLSDPH 715  African clawed frog
CAF97815   745 ELPRQCLIFKEKLGEGQFGEVHLCEIENPqdlpileFPFNVRKGRPLLVAVKILRPDAsknaRNDFLKEVKILSRLKDPN 824  Tetraodon nigrov...
Feature 1                       ####  ##                                                       
AAH70070   647 IIRLLGVCVqddPLCMITDYMENGDLNQFLSAHQLedkaaegapg------------------dgqaaqgptISYQMLLH 708  human
AAH60755   716 IIRLLGACLdedPLCMITEYMENGDLNQFLSSHHLdegeeng------------------------ahclpaISYSSLLH 771  African clawed frog
CAF97815   825 IIRLLGVCVssdPLCMVTEYMECGDLNQYLSHRVLldktgpsndaptirweaeggghmmvpatvppdgpllvPSYPALIS 904  Tetraodon nigrov...
Feature 1                          #   ## #                     #                 #####        
AAH70070   709 VAAQIASGMRYLATLNFVHRDLATRNCLVGEn-----------FTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWEC 777  human
AAH60755   772 VALQICSGMKYLSSLNFVHRDLASRNCLVGEn-----------LTIKIADFGMSRNLYAGDYYRIQGRAVLPIRWMAWEC 840  African clawed frog
CAF97815   905 MASQIASGMKFLSSLNFVHRDLATRNCLVGGergdsgddgggeRHIKIADFGMSRNLYAGDYYRIQGRAVLPIRWMAWEC 984  Tetraodon nigrov...
Feature 1      #                                  #                                            
AAH70070   778 ILMgKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDqgRQVYLSRPPACpQGLYELMLRCWSReSEQ 857  human
AAH60755   841 ILMgKFTTASDVWAFGVTLWEILMLCKEQPYGELSDEDVIENAGEIFRDskKQIFLFRPPPCpQPLYELMLQCWSRdCRE 920  African clawed frog
CAF97815   985 ILMgKFTTASDAWAFGVTLWEMLSVCQEQPYSSLTDEQVIDNAGEFFRDqgRQVYLGRPAVCpQGLYELMLSCWSRdCKL 1064 Tetraodon nigrov...
Feature 1                   
AAH70070   858 RPPFSQLHRFLAE 870  human
AAH60755   921 RPSFQDIHALITS 933  African clawed frog
CAF97815  1065 RPSFSDIHSFLTE 1077 Tetraodon nigroviridis

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