2HEN,2VWU


Conserved Protein Domain Family
PTKc_EphR_B

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cd05065: PTKc_EphR_B 
Click on image for an interactive view with Cn3D
Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Class EphB receptors bind to transmembrane ephrin-B ligands. There are six vertebrate EphB receptors (EphB1-6), which display promiscuous interactions with three ephrin-B ligands. One exception is EphB2, which also interacts with ephrin A5. EphB receptors play important roles in synapse formation and plasticity, spine morphogenesis, axon guidance, and angiogenesis. In the intestinal epithelium, EphBs are Wnt signaling target genes that control cell compartmentalization. They function as suppressors of colon cancer progression. EphRs comprise the largest subfamily of receptor PTKs (RTKs). They contain an ephrin-binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyr kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling). Ephrin/EphR interaction mainly results in cell-cell repulsion or adhesion. The EphB subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 173638
View PSSM: cd05065
Aligned: 16 rows
Threshold Bit Score: 574.125
Threshold Setting Gi: 2739062
Created: 17-May-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 24 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:includes ATP binding and substrate binding sites
  • Comment:Based on the structures of other PTK family members bound to substrate peptides and ATP analogs, and the structures of Eph receptors bound with ATP analogs.
  • Citation:PMID 9312016

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                #####   #               # #                                          
2HEN_A      4 IDISCVKIEQVIGAGEFGEVCSGHLKLpgkREIFVAIKTLKSGYTEkQRRDFLSEASIMGQFDHPNVIHLEGVVTkstPV 83   house mouse
2VWU_A     13 IDVSYVKIEEVIGAGEFGEVCRGRLKApgkKESCVAIKTLKGGYTErQRREFLSEASIMGQFEHPNIIRLEGVVTnsmPV 92   human
Q8CBF3    614 IDVSFVKIEEVIGAGEFGEVYKGRLKLpgkREIYVAIKTLKAGYSEkQRRDFLSEASIMGQFDHPNIIRLEGVVTksrPV 693  house mouse
NP_571489 616 IDVSCVKIEEVIGAGEFGEVCRGRLRIpgkKENYVAIKTLKGGYTDkQRRDFLAEASIMGQFQHPNIIHLEGIITascPV 695  zebrafish
CAB65513  447 IDVSCVKIEEVIGAGEFGEVCRGRLKVpgkKENYVAIKTLKGGYTErQRKEFLSEASIMGQFNHPNIIHLEGVITnncPV 526  African clawed frog
Q91735    604 IDISCVKIEEVIGAGEFGEVCRGKLKQagrREQFVAIKTLKAGYTEqQRRDFLGEASIMGQFDHPNIIRLEGVVTrsrPV 683  African clawed frog
O13147    182 IDISCVKIEEVIGAGEFGEVCRGRLKQagrKETTVAIKTLKAGYTEhQRRDFLSEASIMGQFDHPNVIHLEGVLTrscPV 261  zebrafish
Q91736    532 IDVSFVKIEEVIGAGEFGEVYKGRLKLpskREISVAIKTLKAGYSEkQRRDFLSEASIMGQFDHPNIIRLEGVVTksrPV 611  African clawed frog
Q07494    614 IDVSFVKIEEVIGAGEFGEVYKGRLKLpgkREIYVAIKTLKAGYSEkQRRDFLSEASIMGQFDHPNIIRLEGVVTksrPV 693  chicken
CAG11552  606 IDPSCVKIEEVIGSGEFGEVYKGRLKPigkKEIPVAIKTLKVGYSErQRRDFLSEASIMGQFDQPNIIRLEGVVTksrPT 685  Tetraodon nigrovi...
Feature 1        ## #   #                                       #   ## #          #           
2HEN_A     84 MIITEFMENGSLDSFLRQNdgqFTVIQLVGMLRGIAAGMKYLADMNYVHRALAARNILVNSnLVCKVSDFGLSRFLEDDT 163  house mouse
2VWU_A     93 MILTEFMENGALDSFLRLNdgqFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSnLVCKVSDFGLSRFLEENS 172  human
Q8CBF3    694 MIITEFMENGALDSFLRQNdgqFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSnLVCKVSDFGLSRYLQDDT 773  house mouse
NP_571489 696 MILTEFMENGALDSFLRLNdgqFTPIQLVGMLRGIASGMKYLSEMSYVHRDLAARNILVNSnLVCKVSDFGLSRFLQENS 775  zebrafish
CAB65513  527 MIITEYMENGALDSFLRQNdgqFTPIQLVGMLRGIASGMRYLSEMSFVHRDLAARNILVNSnLVCKVSDFGLSRFLQEGS 606  African clawed frog
Q91735    684 MILTEFMENGALDSFLRMNdgqFTVIQLVGILRGIASGMKYLSEMNYVHRDLAARNILVNSnLVCKVSDFGLSRFLENSR 763  African clawed frog
O13147    262 LIVTEFMENGALDSFLRLNdgrFTVTQLVGMLRGIAAGMKYLSDMNYVHRDLAARNVLVNSnLVCKVSDFGLSRFLDDNS 341  zebrafish
Q91736    612 MIITEFMENGALDSFLRQNdgqFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSnLVCKVSDFGLSRYLQDDT 691  African clawed frog
Q07494    694 MIITEFMENGALDSFLRQNdgqFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSnLVCKVSDFGLSRYLQDDT 773  chicken
CAG11552  686 MIITEFMENGALDSFLRQNdgqFPVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSnLVCKVSDFGLSRYLEEDT 765  Tetraodon nigrovi...
Feature 1              #####        #                                 #                       
2HEN_A    164 SDPTYTSALGGKIPIRWTAPEAIQYrKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSAL 243  house mouse
2VWU_A    173 SDPTETSSLGGKIPIRWTAPEAIAFrKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSL 252  human
Q8CBF3    774 SDPTYTSSLGGKIPVRWTAPEAIAYrKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAAL 853  house mouse
NP_571489 776 SDPTYTSSLGGKIPIRWTAPEAIAFrKFTCASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCSTYL 855  zebrafish
CAB65513  607 TDPTYTSCLGGKIPIRWTAPEAIAFrKFTSASDVWGYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPAPPDCPTAL 686  African clawed frog
Q91735    764 SDPTYTSALGGKIPIRWTAPEAISYrKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAIEQDYRLPPPMDCPSAL 843  African clawed frog
O13147    342 SDPTYTSSLGGKIPIRWTAPEAIAFrKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVMNAVEQDYRLPPPMDCPAVL 421  zebrafish
Q91736    692 SDPTYTSSLGGKIPVRWTAPEAIRYrKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAIEQDYRLPPPMDCPAAL 771  African clawed frog
Q07494    774 SDPTYTSSLGGKIPVRWTAPEAIAYrKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAAL 853  chicken
CAG11552  766 SDPTYTSSLGGKIPVRWTAPEAIAYrKFTSASDVWSYGIVTWEVMSYGERPYWDMSNQDVINAIEQDFRLPAPMDCPVVL 845  Tetraodon nigrovi...
Feature 1                                  
2HEN_A    244 HQLMLDCWQKdRNHRPKFGQIVNTLDKMI 272  house mouse
2VWU_A    253 HQLMLDCWQKdRNARPRFPQVVSALDKMI 281  human
Q8CBF3    854 HQLMLDCWQKdRNSRPRFAEIVNTLDKMI 882  house mouse
NP_571489 856 HQLMLDCWQKeRTARPRFANIVSALDKLI 884  zebrafish
CAB65513  687 HQLMLDCWQRdRALRPRFADIVSSLDKLI 715  African clawed frog
Q91735    844 HQLMLDCWLRdRNLRPKFSQIVSSLDKLI 872  African clawed frog
O13147    422 HQLMLECWVKeRNMRPRFGQIVSTLDKFL 450  zebrafish
Q91736    772 HQLMLDCWQKdRNSRPRFGEIVNTLDKMI 800  African clawed frog
Q07494    854 HQLMLDCWQKdRNTRPRLAEIVNTLDKMI 882  chicken
CAG11552  846 HQLMLDCWQKdRNARPKFPDIVSMLDKMI 874  Tetraodon nigroviridis

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