1LUF


Conserved Protein Domain Family
PTKc_Musk

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cd05050: PTKc_Musk 
Click on image for an interactive view with Cn3D
Catalytic domain of the Protein Tyrosine Kinase, Muscle-specific kinase
PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Musk is a receptor PTK (RTK) containing an extracellular region with four immunoglobulin-like domains and a cysteine-rich cluster, a transmembrane segment, and an intracellular catalytic domain. Musk is expressed and concentrated in the postsynaptic membrane in skeletal muscle. It is essential for the establishment of the neuromuscular junction (NMJ), a peripheral synapse that conveys signals from motor neurons to muscle cells. Agrin, a large proteoglycan released from motor neurons, stimulates Musk autophosphorylation and activation, leading to the clustering of acetylcholine receptors (AChRs). To date, there is no evidence to suggest that agrin binds directly to Musk. Mutations in AChR, Musk and other partners are responsible for diseases of the NMJ, such as the autoimmune syndrome myasthenia gravis. The Musk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 133181
View PSSM: cd05050
Aligned: 6 rows
Threshold Bit Score: 533.641
Threshold Setting Gi: 18150832
Created: 15-Aug-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 26 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:includes ATP binding and substrate binding sites
  • Comment:Based on the structures of other PTK family members bound to substrate peptides and ATP analogs.
  • Citation:PMID 9312016

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 #####   #                 # #                                       
1LUF_A     43 EYPRNNIEYVRDIGEGAFGRVFQARAPGllpyepfTMVAVKMLKEEASadmQADFQREAALMAEFDNPNIVKLLGVCAvg 122  Norway rat
Q9V6K3    435 EYPRGDIVYVRSLGQGAFGRVFQARAPGlvpdqedLLVAVKMLKDDASdqmQMDFEREACLLAEFDHPNIVRLLGVCAlg 514  fruit fly
Q8AXY6    649 EYPRNNIEYVRDIGEGAFGRVFQARAPGllpyepfTMVAVKMLKEEASadmQADFQREAALMAEFDNPNIVKLLGVCAvg 728  chicken
CAC19037   54 EYPRNNIEYVRDIGAGAFGRVFQARAPGllsyepfTMVAVKMLKEEASadmHADFQREAALMAEFDHPNIVKLLGVCAvg 133  African clawed frog
AAT07679  640 EYPRNNIEYVRDIGEGAFGRVFQARAPGllptepfTMVAVKMLKEEAStdmQNDFQREAALMSEFDHPNIVRLLGVCAvg 719  zebrafish
BAA81716  611 EVDRDKVRYEGDLGQGHFGLVVKATALGvvpgrdqCIVAVKILKEGASlqtKKEFFHEAALMHSFDHPNIVKLIGVCVeq 690  Ephydatia fluviat...
Feature 1           ####  ##                                                               #  
1LUF_A    123 kPMCLLFEYMAYGDLNEFLRSMsphtvcslshsdl-strarvsspgpppLSCAEQLCIARQVAAGMAYLSERKFVHRDLA 201  Norway rat
Q9V6K3    515 rPMCLLFEYMAPGDLSEFLRACspyathqa------------ptqdrlqLNELHLLQMAANIAAGMLYLSERKFVHRDLA 582  fruit fly
Q8AXY6    729 kPMCLLFEYMAYGDLNEYLRDRsprnlcslvqgg---learacllnplaLCCTSQLCIAKQVAAGMAYLSERKFVHRDLA 805  chicken
CAC19037  134 kPMCLLFEYMAHGDLNEYLRHRspralsslshssl-aakvrlcdlnpspLSCTDQLCIAQQVAAGMAYLSERKFVHRDLA 212  African clawed frog
AAT07679  720 kPMCLMFEYMAYGDLNEFLRRRcatqqpslsrdtltssslvseperyppLSCQEQLSISKQVAAGMAYLSERKFVHRDLA 799  zebrafish
BAA81716  691 ePLCMIFEFMQLGDLNNFLRHNspkwqessas-------cakyggpkcdITTPIQVAMSLDITAGLAYLADNHYIHRDLA 763  Ephydatia fluviat...
Feature 1      ## #          #                 #####        #                                 
1LUF_A    202 TRNCLVGEnMVVKIADFGLSRNIYSADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMA 281  Norway rat
Q9V6K3    583 TRNCLINEhMAVKIADFGLSHKIYLQDYYKGDENDFIPIRWMPLESILYNKFSLESDVWAYGICLWEVFSFALQPYFGLT 662  fruit fly
Q8AXY6    806 TRNCLVGEnMVVKIADFGLSRNMYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGMQPYYGMA 885  chicken
CAC19037  213 TRNCLVGEnAVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGMQPYYGMA 292  African clawed frog
AAT07679  800 TRNCLVAEnLVVKIADFGLSRNIYAADYYKASENDAIPIRWMPPESIFYNRYTSESDVWAYGVVLWEIFSYGMQPYYGMA 879  zebrafish
BAA81716  764 TRNCLVSGdLRIKISDFGLSQDIYSTDYCRLSQSELLPIRWMPPEAILFARFTTQSDVWSLGVVLWELFSYGIQPYYSMS 843  Ephydatia fluviat...
Feature 1     #                                                  
1LUF_A    282 HEEVIYYVRDGNILACPENCpLELYNLMRLCWSKlPADRPSFCSIHRILQR 332  Norway rat
Q9V6K3    663 HEEVIKYIKEGNVLGCPDNTpLSVYALMRRCWNRkPSERPGFAEINHCIQH 713  fruit fly
Q8AXY6    886 HEEVIYYVRDGNILSCPDNCpLELYNLMRLCWSKlPADRPSFASIHRILER 936  chicken
CAC19037  293 HEEVIYYVRDGNILSCPENCpLELYNLMRLCWSKmPSDRPSFACIYRILER 343  African clawed frog
AAT07679  880 HEEVIYYVRDGNVLSCPENCpQELYNLMRLCWSGhPTDRPSFASIHRILER 930  zebrafish
BAA81716  844 NEQVIAHVRDGNVMNCPDGCpSEIYDLMVDCWNMdPGQRPTAADVNVALQR 894  Ephydatia fluviatilis

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