Conserved Protein Domain Family
PTK_CCK4

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cd05046: PTK_CCK4 
Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4
CCK4, also called protein tyrosine kinase 7 (PTK7), is an orphan receptor PTK (RTK) containing an extracellular region with seven immunoglobulin domains, a transmembrane segment, and an intracellular inactive pseudokinase domain, which shows similarity to tyr kinases but lacks crucial residues for catalytic activity and ATP binding. Studies in mice reveal that CCK4 is essential for neural development. Mouse embryos containing a truncated CCK4 die perinatally and display craniorachischisis, a severe form of neural tube defect. The mechanism of action of the CCK4 pseudokinase is still unknown. Other pseudokinases such as HER3 rely on the activity of partner RTKs. The CCK4 subfamily is part of a larger superfamily that includes other pseudokinases and the catalytic domains of active kinases including PTKs, protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 133178
View PSSM: cd05046
Aligned: 8 rows
Threshold Bit Score: 448.067
Threshold Setting Gi: 1401236
Created: 15-Aug-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q13308     790 HFPRSSLQPITTLGKSEFGEVFLAKAqglee------------------------------------------------- 820  human
CAG05180   791 HFPRANLQTITILGKGEFGEVLLCKAkgiee------------------------------------------------- 821  Tetraodon nigrov...
AAH60500   763 SFPRANLHPITTLGRGEFGEVFLAKApnpds------------------------------------------------- 793  African clawed frog
AAB03389   582 IFNYENLQEIIVLGYGKFGKVFKAYAkgice------------------------------------------------- 612  Hydra vulgaris
AAT94478   686 ALPRSGLSELIQIGRGEFGDVFVGKLkatlvtspsdkdadtekqhsnsengsggsgsgsttlstlnekrrsktsmddiee 765  fruit fly
XP_972111  805 ALSRTHLKEMKLIGRGEFGEVMVAKMsksallsekrns------------------------------------------ 842  red flour beetle
EAT40388   423 AVPRSSVIEMLQIGKCDFGDVFIGKIkendcktakaetvkepvtgdevthasnt--------------evttedekitkk 488  yellow fever mos...
8134651    771 HFPRSNLQTITTLGRGEFGEVFLAKAkgaed------------------------------------------------- 801  chicken
Q13308     821 -----------gvaeTLVLVKSLQSKDeq-qQLDFRRELEMFGKLNHANVVRLLGLCReaePHYMVLEYVDLGDLKQFLR 888  human
CAG05180   822 -----------skeeTVVLVKSLQSRDeq-lQLDFRREAEMFAKLSQPNIVRLLGLCReaePHYMILEYCDLGDLKQFLR 889  Tetraodon nigrov...
AAH60500   794 -----------tsgeAVVLVKALQTRDeq-lQMDFRRELDMFSKLNHANVVRLVGQCReaePHYMVLEYIDLGDLKQFLR 861  African clawed frog
AAB03389   613 -----------egtdTLVAVKVFEETPvnnvLSAFNKETEDLMQFQNSYVVRLLGLVRe-sPFCIITEYSELGDLKEYLQ 680  Hydra vulgaris
AAT94478   766 ikeeeqdqhnqsgleQLVLVKALNKVKdeqaCQEFRRQLDLLRAISHKGVVRLFGLCRekdPHYMVLEYTDWGDLKQFLL 845  fruit fly
XP_972111  843 ----qattppiedkeLPVLVKALSHTKdensLSEFKREIDMFLKLSHENITKIYGLCReaePHYMILEHTDWGDLKQFLV 918  red flour beetle
EAT40388   489 psneelneikpendyKPVMVKALTKVKdehcCSEFRRQLDLFRTVSHKNVVKLFGLCRdkdPHYMLLEYTDWGDLKQFLL 568  yellow fever mos...
8134651    802 -----------aegeALVLVKSLQTRDeq-lQLDFRREAEMFGKLNHVNVVRLLGLCReaePHYMVLEYVDLGDLKQFLR 869  chicken
Q13308     889 ISkskdek---------lksqpLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAqRQVKVSALGLSKDVYNSE 959  human
CAG05180   890 ISkskddk---------vksqpISTKTKVSICAQVAHGMEHLSNHRFVHKDLAARNCLISSqRRVKISSLSLSKDVYNSE 960  Tetraodon nigrov...
AAH60500   862 ISrsree-----------kpkpLSSKHKVSLCTQVALGMEHLSNSRFVHKDLAARNCLVSAqRLVKVSALGLSKDVYSSE 930  African clawed frog
AAB03389   681 TNk------------------nTSSSARLHMCTCIAKGMSYLATLHYVHRDLAARNCILFSqNEVKVSFLSLCNTTYKDD 742  Hydra vulgaris
AAT94478   846 ATagkvntat----agssspppLTTSQVLAVAYQIARGMDAIYRARFTHRDLATRNCVISSeFIVKVSYPALCKDKYSRE 921  fruit fly
XP_972111  919 ATqkgs-------------pppLTPVQCVAIVHQLCQGLDHLATSRLIHRDLAARNCLVTStLKAKVGLPRLTRDPYSQE 985  red flour beetle
EAT40388   569 ATspaippngsveaknvnkpppLNVPQILALAHQIGRGMDAIYKARIIHKDLATRNCIISSdFSAKISLPGLSRDKYNKE 648  yellow fever mos...
8134651    870 ISkskdes---------lkpqpLSTKHKVSLCTQVALGMEHLSNGRFVHRDLAARNCLVSAqRQVKVSALSLSKDVYNSE 940  chicken
Q13308     960 YYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTH-GEMPHGGQADDEVLADLQaGKARLPQPEGCpSKLYR 1038 human
CAG05180   961 YYHYRQAWIPLRWLPSESVFEDDFSTKSDVWAFGVLMWEVFSY-GELPHSKLSDDEMLEALKaGKLKLPVPDGCpSRIYK 1039 Tetraodon nigrov...
AAH60500   931 YHPLRQTKVPLRWMSPEAVQDDDFSTKSDVWSFGVLMWEVFTL-GELPYTSLPDEEVLAGLQnGSLKLPAPEGCsSRVYR 1009 African clawed frog
AAB03389   743 YYLLNNLLAPVRWLAPESIRENIYNEKTDVWSFSVTMWEIFSS-EVQPFYGVSNEEVVNRIG-KDLQLTIPSNCpKTLYK 820  Hydra vulgaris
AAT94478   922 YHKHRNTLLPIRWLAPECIQEDEYTTKSDIFAYGVVVWELFNQaTKLPHEELTNEQVVQRSQaGSLEWSVAEATpDSLRE 1001 fruit fly
XP_972111  986 YCKHVNHIIPLRWLPYEAVYEDEYSTKSDVYSFAVVIWEIFNQ-GELPFPKMNDTSFLNKLKeKKLEWKPHSSTpESLQK 1064 red flour beetle
EAT40388   649 YFKYKNQLMPVRWMAPECLQDDDFSIKSDIFSFAVLLWELFTTaTELPFKDLTDEEYVTQAQsGKLEWKLADKTpENLHK 728  yellow fever mos...
8134651    941 YYHFRQAWIPLRWMPPEAVLEDEFSTKSDVWSFGVLMWEVFTQ-GEMPYAPLADDEVLAGLKsGKTKLPQPEGCpSRLTK 1019 chicken
Q13308    1039 LMQRCWALsPKDRPSFSEIASALGD 1063 human
CAG05180  1040 LMARCWAPgLKERPSFTDIVQALGE 1064 Tetraodon nigroviridis
AAH60500  1010 LMQRCWAPsPKDRPSFSEIVNALGD 1034 African clawed frog
AAB03389   821 IMTRCWLVnAFDRPTFDELLSLMAE 845  Hydra vulgaris
AAT94478  1002 ILLSCWVSnPKERPSFSQLGAALSK 1026 fruit fly
XP_972111 1065 LQASCWDSnPQNRPTFSELAKEIEE 1089 red flour beetle
EAT40388   729 ILTSCWSVnPKERPSFSQLVVAIGN 753  yellow fever mosquito
8134651   1020 LMQRCWAPsPKDRPSFSELAAALGD 1044 chicken
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