2PCS,2NS9


Conserved Protein Domain Family
CoxG

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cd05018: CoxG 
Click on image for an interactive view with Cn3D
Carbon monoxide dehydrogenase subunit G (CoxG)
CoxG has been shown, in Oligotropha carboxidovorans, to anchor the carbon monoxide (CO) dehydrogenase to the cytoplasmic membrane. The gene encoding CoxG is part of the Cox cluster (coxBCMSLDEFGHIK) located on a low-copy-number, circular, megaplasmid pHCG3. This cluster includes genes encoding subunits of CO dehydrogenase and several accessory components involved in the utilization of CO. This family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.
Statistics
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PSSM-Id: 176853
View PSSM: cd05018
Aligned: 54 rows
Threshold Bit Score: 114.218
Threshold Setting Gi: 168698870
Created: 12-Dec-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 46 residues -Click on image for an interactive view with Cn3D
Feature 1:putative hydrophobic ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          # # #          ### ##     #   #     #     # # # # #           #   #   ###  #  
2PCS_A         3 LNGNGSIELKG--TVEEVWSKLMDP-SILSKCIMGCKSLELIGeDKYKADLQIGI-------AAVKGKYDAIIEVTDIKP 72  Geobacillus kau...
2NS9_A        13 VRYEGSFEVSK--TPEEVFEFLTDP-KRFSRAFPGFKSVEVED-GSFTIELRLSL-------GPLRGDARVRASFEDLEK 81  Aeropyrum pernix
NP_559208      3 VDESGQFHVDK--PPAKVVELLTKP-EVVARLIPGVSKVEKAG-DEYVGEAVVKL-------GHLSGKMATRFKYAEVRD 71  Pyrobaculum aer...
YP_001540402   1 MKLSGQKPWGVgvNVENLWQLIENNtIALVKCVPDTSDIKQIGpQEFEFKIMVRM-------GPVSGTFNSRVKIESIDK 73  Caldivirga maqu...
ZP_02731147    2 IHFEGDKRIGR--PVAEVAAKLSDA-GFLANSVPDAEVSENTP-DRATGKIKPKL-------SFLTGSLTLHAEVTTRVP 70  Gemmata obscuri...
YP_001541609   4 LHYSGSFNLTK--PPREVTGALSNL-SLVIKCIPNVTSYELISeSKAKVRFRVDLgdevpvaELRRVTSDTVIEVTEASE 80  Caldivirga maqu...
NP_343865      1 MEFKGTFDVKR--TIEAVKGFLINP-KQFAECLTGLQSYETNN-NVFKAIFKLDVsq---mkIPHMTTLTASINANIIEK 73  Sulfolobus solf...
YP_256620      1 MEISGEFVVNM--VKAKVSEFFTEP-KMFTECLPSLQGYEIKGdNEISATFKIDVsg---fnIPHMSTITANINAKIIKD 74  Sulfolobus acid...
NP_111358      1 MDYSGSFYVDR--DPAEVKQFISNF-ENVVACLPGIDSYTNNG-NEFECRIRLDIss---lsNSYLKHISGKMKFLFVPE 73  Thermoplasma vo...
YP_024266      2 LNFNGEFEINS--DIERAYNILSDY-NNLIKLIPDLIEYHIEE-NRLKITAKAGV-------SFIKGKFNLEISYGNNID 70  Picrophilus tor...
Feature 1             # # #          ### # #         # # # #               ##### ### ###  #     
2PCS_A        73 p--YHYKLLVNGEGGPGFVNAEGVIDLTpindeCTQLTYTYSAEVGG-KVAAI-GQRMLGGVAKLLISDFFKKIQKEIA 147 Geobacillus kaus...
2NS9_A        82 p--SKATVKGSGRGAGSTLDFTLRFAVEps-ggGSRVSWVFEGNVGG-LAASM-GGRVLDSLARRMINDVISGVKRELG 155 Aeropyrum pernix
NP_559208     72 ---DGVVITGRATGMQTTADFKIEVAVKps-ggGSLVDWRFQGEARG-LAATL-APSVVKGALRKMAEEAAQNLAQYIN 144 Pyrobaculum aero...
YP_001540402  74 a-sGKVAMTLNSKGPGAVMNASITATIS-----QTGVSYDADVNLSG-LLAAV-GERLIRNYIDGKLNEFLTNLVKLAK 144 Caldivirga maqui...
ZP_02731147   71 gksVAYRIETKTMGASSTVETTLVFGEAe---gGTLVHWTGDIVAVTgLLKMV-PKGLLEGTAKKVIEDVWAAVESKIT 145 Gemmata obscurig...
YP_001541609  81 ---SSIRLRVNGRAAGSSIEVTLSIIVEpn-ngGSRVNWSADAGLGR-LLQMMgRFINIDSMVERIANDTINGIVKCLS 154 Caldivirga maqui...
NP_343865     74 e--NSVEINGDGRSAGVGIKFNIILGLKkd-egITRVNWFAKINLGM-LSRLL-GEENIRRIAEPNINHIINCISSKLS 147 Sulfolobus solfa...
YP_256620     75 n--EKIEIVGNGRSAGVSVKINISLNLYem-qkSTKVIWSAKMDMGL-LTKLL-GENSIRKIAESNVNYIINCIRSRVT 148 Sulfolobus acido...
NP_111358     74 r-dNGISVNGSGRIAGSSVSMNVKVFVEgs-neHAKVTWSAAIDYGL-ILKAM-GSEKIKEVTDENIKRSIECLRGKIS 148 Thermoplasma vol...
YP_024266     71 n--KRIEITAKGSGSGVSVDFKAYFDYSgn--nPVNVKYSADVNIAG-AAAAA-GSRMIKGSADKYINRLISNYRQAAE 143 Picrophilus torr...

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