CoxG has been shown, in Oligotropha carboxidovorans, to anchor the carbon monoxide (CO) dehydrogenase to the cytoplasmic membrane. The gene encoding CoxG is part of the Cox cluster (coxBCMSLDEFGHIK) located on a low-copy-number, circular, megaplasmid pHCG3. This cluster includes genes encoding subunits of CO dehydrogenase and several accessory components involved in the utilization of CO. This family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.
Feature 1:putative hydrophobic ligand binding site [chemical binding site]
Evidence:
Comment:based on the binding of a Geobacillus kaustophilus conserved CoxG-like protein to an unknown ligand, and on the structures of other SRPBCC domain superfamily members with bound ligands
Structure:2PCS_A; Geobacillus kaustophilus conserved protein, binds unknown ligand in the ligand binding pocket, contacts at 4A
Jiyao W et al.(2023). "The conserved domain database in 2023.",