1TZC,1X9I


Conserved Protein Domain Family
SIS_PGI_PMI_1
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cd05017: SIS_PGI_PMI_1 
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The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to fructose 6-phosphate, and mannose 6-phosphate to fructose 6-phosphate, respectively at an equal rate. This protein contains two SIS domains. This alignment is based on the first SIS domain.
Links
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Statistics
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PSSM-Id: 240148
Aligned: 20 rows
Threshold Bit Score: 122.759
Created: 28-Mar-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitedimer interface
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1X9I_A: Pyrobaculum aerophilum (PGI/PMI) binds glucose 6-phosphate, contacts calculated at 3.5A
  • Structure:1TZC_A: Pyrobaculum aerophilum PGI/PMI binds enzyme inhibitor 5-phosphoarabinonate, contacts calculated at 3.5A
  • Comment:phosphoglucose/phosphomannose isomerase (PGI/PMI)
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              # # #                                            # #  #                   
1TZC_A        39 RLYISGMGG-SGVVADLIRDFSLtwn-wevEVIAVkdyfl-----kardgLLIAVSYSGNTIETLYTVEYAKRRr-iPAV 110 Pyrobaculum aer...
1X9I_A        39 RLYISGMGG-SGVVADLIRDFSLtwn-wevEVIAVkdyfl-----kardgLLIAVSYSGNTIETLYTVEYAKRRr-iPAV 110 Pyrobaculum aer...
NP_378246     28 ELVYLGIGG-SGIPGRILEILELpvkyqlfRGYKVkvn---------eksTVIAVSYSGNTTETIFALLTSLKKt-rKAI 96  Sulfolobus toko...
YP_254865     28 KIAYFGIGG-SGIPGEVLKLLDLpveyklfRSYKVnvd---------sktTVVAVSYSGNTAETLAGVKRAQELgvkEII 97  Sulfolobus acid...
YP_429483     51 QIMFLGTGGgSAASVDLLASYLFdei--kiPLFLNrgytipa--sidnrtLVVVVSHSGKTEEILNAYHQVCTTe-aQII 125 Moorella thermo...
ZP_01188079   51 NIILLGTGGgSAITGGLLQSYLFdel--pvPLYINqgynipa--wvdentLVLVVSHSGNTEEIVNSFKQAEQRg-aCIF 125 Halothermothrix...
NP_147479     31 EIYYCGMGG-SGAAGDYIEALLSiya-pqgPEFRVvkdfrpprpprhrgyGLVLASYSGNTLETVECGSLLSPAa-gRVV 107 Aeropyrum perni...
YP_001013616  38 TVVVCGMGG-SGAAGDYLAQLSAhyg--gvPIYVVkaasvpg--wvgsksLVYAVSFSGNTRETLECAVKAYRQg-aKLV 111 Hyperthermus bu...
YP_001041159  30 LVFIAGMGG-SGIVGDYVAALSNvkg--siPVLVSkshlvpn--flsrddLVFIVSYSGNTLETRIAYEKIAEKk-sRIV 103 Staphylothermus...
YP_001191920  26 EVFCFGMGG-SGVACEVMSAFYPl-----lRDMRHa-------------dVVIAVSYSGNTRETLEIVRKATSAg-kRIV 85  Metallosphaera ...

Feature 1                                    ##                
1TZC_A       111 AITTGGRLaqm----gvPTVIVPKas-aPRAALPQLLTAALHVVAK 151 Pyrobaculum aerophilum str. IM2
1X9I_A       111 AITTGGRLaqm----gvPTVIVPKas-aPRAALPQLLTAALHVVAK 151 Pyrobaculum aerophilum
NP_378246     97 VITSGGKIeeiaskhnlPVIKLPKgl-qTRFVFPYIFTYLIRIINE 141 Sulfolobus tokodaii str. 7
YP_254865     98 VITSGGKLkeiaeskgyPLLSLPQgy-qTRFIFPYIFTYLVRILNQ 142 Sulfolobus acidocaldarius DSM 639
YP_429483    126 VLTSGGKLlslargnkhPYLLIPGgm-mPRIAVGYIFLPLLGLLQR 170 Moorella thermoacetica ATCC 39073
ZP_01188079  126 ILTSGGILgekareqgiPHLIVPRdighPRRDLGYIFIPLLALLNK 171 Halothermothrix orenii H 168
NP_147479    108 AVTSGGRLlemakergwLVARLPGgi-lPRVSFPWMLAASTAMLSG 152 Aeropyrum pernix K1
YP_001013616 112 AVTRGGLLgswakrhgvPVAFIGEap-aPRAGWPNLFYTMLGSLES 156 Hyperthermus butylicus DSM 5456
YP_001041159 104 IVSSNGLLesiatennlPFIPIVKgi-aPRTALPHMLYAILGVLDS 148 Staphylothermus marinus F1
YP_001191920  86 AITSGGALatl----pvERILVRGgd-qPRYSFPLLFLPLVKMLRP 126 Metallosphaera sedula DSM 5348

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