Conserved Protein Domain Family
SIS_Kpsf
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cd05014: SIS_Kpsf 
KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-phosphate to arabinose 5-phosphate. This is the second step in the CMP-Kdo biosynthesis pathway.
Links
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Statistics
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PSSM-Id: 240145
Aligned: 47 rows
Threshold Bit Score: 145.763
Created: 26-Mar-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative active
Feature 1:putative active site [active site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                  #                                           #                         
ZP_00959577   46 GRVIVSGMGKSGHIAHKIAATMASTGtpaqmVHPGEASHGDLGmitaQDAVILISNSGEtRELADMIAHtrrf-----si 120 Roseovarius nub...
YP_001071087  48 GKVVTTGSGTSGIMAERLAHLLSVCGtpavyLPAMDALHGGMGavtaHDLVLAISKTGRsAELTRLTERlvdr-----gv 122 Mycobacterium s...
XP_454112     45 GKLIFVGCGKSYKIICKTVAMLTSMGipardLHPIEAMHGDMGccqpNDSLIFCSTSGEtDEVLNLLRYlkaggsywekc 124 Kluyveromyces l...
XP_001643775  48 GKVIIVGCGKSYKIASKIVVMLNSLGmsstlLHPIEAIHGDMGvireGDVIWMCSHGGEtLEVIKFIELvhkvws-cnai 126 Vanderwaltozyma...
NP_986091     98 RKLVFVACGKSFRIIAKTVATCHSLGipaavLHPTEAMHGDIGivadGDALLLCSHSGEtDELLHLAAYlrsarl-apas 176 Ashbya gossypii...
EDP12174      43 KRVHVTGIGKPGHVAGYIASLLSSTGtpsyeLHGTEAVHGSSGqvltGDVVIAISNSGEtSELKATVDTllkn-----ga 117 Eubacterium dol...
YP_001470815  39 GKIIATAFGKNVPICEKFVGTLISVGidsyfLHTNSAIHGDLGvikeKDIVILLTKSGEtEESIYLYKQlqkr-----na 113 Thermotoga lett...
ZP_02012321   12 RKLIFTGVGKSAHISIKLAGTFNSTGipscfLDATQALHGDLGlcaeGDVVILLSNSGQsDEVIKLVTLlkrf-----gv 86  Opitutaceae bac...
NP_407093     45 GKIAVTGVGTSGIAARKVAHMLACVEqpaiyLNATDAAHGDLGflgaQDIIILISRGGNsDELTRLLPTlqrk-----qv 119 Yersinia pestis...
NP_464030     45 GKIVVAGCGTSGVAAKKLVHSFNCIErpavfLTPSDAVHGTLGvlqkEDILILISKGGNtGELLNLIPAcktk-----gs 119 Listeria monocy...

Feature 1                                                                    
ZP_00959577  121 pLIAITkka--estLGQQADHVLelp----dapEACGIGMa-PTTSTTCTLALGDALAVA 173 Roseovarius nubinhibens ISM
YP_001071087 123 dVVAITedakspfaLAATQVQALpr------tpGDADPGGmiALASTLVVGAWGDALAVV 176 Mycobacterium sp. JLS
XP_454112    125 iRIAVTgnr--nstLATHCQHTIvvpqadrfkePKFQRGLraPTISTSLMVTVLDCICIE 182 Kluyveromyces lactis NRRL Y-1140
XP_001643775 127 tTIGITske--estVSRICDHKIvikq--yikeDILQRGLktPTISTSSMLIVLDCIVMS 182 Vanderwaltozyma polyspora DSM 70294
NP_986091    177 pLIAVTgdp--astLARRAHHVItvfqpphlreRVVQDGLnaPTIATTLMLLALDCLVLA 234 Ashbya gossypii ATCC 10895
EDP12174     118 rIISCTgne--hssLAQSSEVCLkaq----vgrEGDSLNKp-PRASILAEIIVLQLLSDL 170 Eubacterium dolichum DSM 3991
YP_001470815 114 nTYIMTynk--egtLAKLCPKSIilt----lehEGDKWNLi-PNNSTIGFLFVLQAVAME 166 Thermotoga lettingae TMO
ZP_02012321   87 vIVAFTsnp--dseLARHTPLRLlyr----vprEACPLGIa-PTASTTAPSRLATRWPWC 139 Opitutaceae bacterium TAV2
NP_407093    120 kIISVTene--qsaIAQVSALVLkth----vkqEIDPLNMl-ATTSIVLVLALFDAICAC 172 Yersinia pestis CO92
NP_464030    120 tLIGVTenp--dsvIAKEADIFFpvs----vskEPDPFNMl-ATASTMAVIASFDAVIVC 172 Listeria monocytogenes EGD-e

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