1X92,1TK9,1X94


Conserved Protein Domain Family
SIS_GmhA
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cd05006: SIS_GmhA 
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Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of gram-negative bacteria inner core lipopolysaccharide precursor, L-glycero-D-mannoheptose (Gmh).
Links
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Statistics
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PSSM-Id: 240139
Aligned: 151 rows
Threshold Bit Score: 119.922
Created: 28-Mar-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitedimer interface
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1X92: Pseudomonas aeruginosa phosphoheptose isomerase binds substrate D-glycero-D-mannopyranose-7-phosphate, contacts calculated at 3.5A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                  ###                                  
1X92_A       13 FQASIETKQQALev--lpPYIEQASLVMVNALl-nEGKILSCGNGGSAGDAQHFSSELLnrfere-rpslpAVALttdSS 88  Pseudomonas aeru...
NP_772060    23 DDYVGRLHRATAiddgvfAGISATRTAWLRTRe-qGGRVIFIGNGGSAGIASHLAIDLAkna------svpALCFs-dAS 94  Bradyrhizobium j...
NP_949264    39 ATLAAAQASDCEgrpfaqEVAASLVIAWAREVhadGRKLMFIGNGGSAAIASHMATDYSkng------gmrALCLn-dGA 111 Rhodopseudomonas...
ZP_00518459  25 FQASDNQGYPLSf----aEGVNQAAKVVAAQTqqqTNKVIFIGNGGSAAVASHQAIDYWrng------gfrAISFn-dGA 93  Crocosphaera wat...
YP_419466    16 DAYAEQVNRALAtv--srDHLAAAAKLLSEALa-aDAQLYSCGNGGSAAISNHLVCDHTkgvctdtglkprVHSLsatVE 92  Magnetospirillum...
CAF31845     17 WDEYLATAGPLLgs--mgAQVRSLVTELDAVRh-eGSTVYLAGNGGSASAASHLAQDLLkgaydg-grplrSVALtdnLS 92  Streptomyces hyg...
YP_512182    12 ASYYQRFAEALIaf--dkGPMVDVLAVFDRVIe-aKGTVWVAGNGGSAAIADHTVCDSSkgthveghppfrTISLasnVP 88  Jannaschia sp. CCS1
YP_595582    18 SVEVSISGGNSLsl---eDGFIHWVQKTEELRn-tNRTVFFIGNGASASMASHFSADLTkna-------qiNTKVftdLS 86  Lawsonia intrace...
YP_866205    14 ESLQQTNCHLQGrpcsrqRGFERTQQLLEKQQq-qSGQIWWIGNGGSNALCSHLSQDMInkl------alrSHTFs-dAS 85  Magnetococcus sp...
CAM77204     17 SDYSARIVQALAsv--dtRQLERANEILAETId-hDRQIFSCGNGGSAAIANHLVCDHArgicnltglrprVQSLssnIE 93  Magnetospirillum...

Feature 1                                       ###  #                                          
1X92_A       89 TITSIANDysynevfskqiralgqpGDVLLAISTSGNSaNVIQAIQAAHDre---mlVVALTGrdgggmaslllpeDVEI 165 Pseudomonas aeru...
NP_772060    95 MMSCLANDygfedwiahavrlsaraGDCLVAISSSGRSkNILNAVAQARSmk---ldVITMSGmnadnp--lrnlgDVNF 169 Bradyrhizobium j...
NP_949264   112 MLTCLGNDygyeqvfakqielfaqeGDLLIAISSSGRSpNILNAVAAARArg---crVITLSGfsadnp--lrregDINF 186 Rhodopseudomonas...
ZP_00518459  94 LLTCIGNDfgyeqvfskpismfaqsGDVLIAISSSGQSaNILAGVEQARKlg---cfVITLSAfksdnp--lrqlgDLNF 168 Crocosphaera wat...
YP_419466    93 MLTAIANDidyaevfsyqvgllgrrGDVLITISSSGNSeNVTRAILKAREig---mkSIALTGfeggr---trdlaDVAL 166 Magnetospirillum...
CAF31845     93 MLTAYANDcgydrvfveplahlaapADRLLVISCSGTSaNVVAAAEWAREag---lrVIAVTAgdggr---lrelaDVEV 166 Streptomyces hyg...
YP_512182    89 MLTAIGNDisydavfseqlkyylteKDALLVVSSSGNSpNVVNACQYANEfg---vpTIAFVGfkggr---lkdmaHHVV 162 Jannaschia sp. CCS1
YP_595582    87 LLTAIGNDlgfeyvfsvpfardvcsGDMLVVISCSGESpNVVNTIRLAQSmqekqifCVSLTGkhfsnt--vrqlgDLNF 164 Lawsonia intrace...
YP_866205    86 LLTCMANDngyaavfleplkklarpGDLLIAISSSGNSeNILCCGQWALDng---ldLITLSAfapdna-lwqlpaQVAF 161 Magnetococcus sp...
CAM77204     94 IITAIANDasyadvfchqldlmarpGDALITISSSGDSeNVVRAIAHARAng---iaTIAMTGfsggr---satgaDVNI 167 Magnetospirillum...

Feature 1             #   #                
1X92_A      166 RVPskiTARIQEVHLLAIHCLCDLIDR 192 Pseudomonas aeruginosa
NP_772060   170 WVDsrsYNIVETTHQFWMMAAIDLVIG 196 Bradyrhizobium japonicum USDA 110
NP_949264   187 YLAsdqYGFVELGHLTICHAILDFACG 213 Rhodopseudomonas palustris CGA009
ZP_00518459 169 YVPtqsYGFAEITHLSICHCILDGLMK 195 Crocosphaera watsonii WH 8501
YP_419466   167 HVEadnYGVVEDCHQALMHVLAQYIRM 193 Magnetospirillum magneticum AMB-1
CAF31845    167 NAPtkdVGLAEAMHSLVFHFVTQCLRD 193 Streptomyces hygroscopicus subsp. hygroscopicus
YP_512182   163 HVEvenYGIVEDAHQSLIHCLTQYMKA 189 Jannaschia sp. CCS1
YP_595582   165 YVPtnaYGECESCHAIILHHWMDSIQV 191 Lawsonia intracellularis PHE/MN1-00
YP_866205   162 HLPctlYGHAEVGHEALLHGIIETLWL 188 Magnetococcus sp. MC-1
CAM77204    168 HVDadnYGVIEDVHQSLMHVLAQFIRQ 194 Magnetospirillum gryphiswaldense MSR-1

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