2OTU,1LIL,1NFD,1DL7,1CD0,1AQK


Conserved Protein Domain Family
IgV_L_lambda

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cd04984: IgV_L_lambda 
Immunoglobulin (Ig) lambda light chain variable (V) domain
The members here are composed of the immunoglobulin (Ig) light chain, lambda type, variable (V) domain. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.
Statistics
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PSSM-Id: 409373
View PSSM: cd04984
Aligned: 9 rows
Threshold Bit Score: 156.853
Threshold Setting Gi: 146387039
Created: 25-Sep-2007
Updated: 17-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Structure:2OTU; mouse Fv heterodimer, light and heavy chain interface, contacts based on 3.5 A distance.
    View structure with Cn3D
  • Comment:Dimerization of Ig domains from different chains is common, but not found in all members.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                        # #                                          
2OTU_A      4 VLTQSSSASFSLGASAKLTCTLSsq--hsTYTIEWYQQQPLKPPKYVMELkkdgSHSTGDGIPDRFSGSSSg--aDRYLS 79  house mouse
1LIL_A      2 EVTQPPSLSVSPGQTARITCSGEkl---gDAYVCWYQQRPGQSPVVVIYQ----DNRRPSGIPERFSGSSSg--nTATLT 72  human
1NFD_E      2 ELIQPSSASVTVGETVKITCSGDql---pKNFAYWFQQKSDKNILLLIYM----DNKRPSGIPERFSGSTSg--tTATLT 72  Mus musculus
1DL7_L      3 VVTQESALTTSPGETVTLTCRSStgavttSNYANWVQEKPDHLFTGLIGG----TKHRTPGAPARFSGSLIg--dKAALT 76  Mus musculus
1CD0_A      3 MLNQPHSVSESPGKTVTISCTRSsgn-idSNYVQWYQQRPGSAPITVIYE----DNQRPSGVPDRFAGSIDrssnSASLT 77  Homo sapiens
1AQK_L      3 VLTQPPSVSGAPGQRVTISCTGSnsnigaGFTVHWYQHLPGTAPKLLIFA----NTNRPSGVPDRFSGSKSg--tSASLA 76  human
AAR84018    3 VLTQPASLSASPGASASLTCTFSgglnvaGYHIFWYQQKPGSPPRYLLRYksdsDKGQGSGVPSRFSGSKDasanTGILR 82  rhesus monkey
AAL40095   21 SITQPVSESVKLGETVRISCTLSgas-isGYHVNWYQQKAGNRPRYLLRFysdsNKHQGDGVPDRFSGSKDspnnIGYLT 99  African clawed frog
AAH73596   22 VLTQPASVSVSVGGTVTLTCQGNni---gGKYVHWYQQILPSAPRLIIYE----NSQRPAGIPERFSGTNSg--nTASLT 92  African clawed frog
Feature 1               #                #        
2OTU_A     80 ISNIQPEDEAIYICGVGDtikeqfVYVFGGGTKVTV 115 house mouse
1LIL_A     73 ISGTQTLDEADYYCQVWDsn---aSVVFGGGTKLTV 105 human
1NFD_E     73 ISGAQPEDEAAYYCLSSYgd--nnDLVFGSGTQLTV 106 Mus musculus
1DL7_L     77 ITGAQTEDEAIYFCALWYs----nHWVFGGGTKLTV 108 Mus musculus
1CD0_A     78 ISGLKTEDEADYYCQSYDa----rNVVFGGGTRLTV 109 Homo sapiens
1AQK_L     77 ITGLQAEDEADYYCQSYDss---lSARFGGGTRLTV 109 human
AAR84018   83 ISGLQSEDEADYYCAIGHs----sGGLFGGGTRLTV 114 rhesus monkey
AAL40095  100 IKGALLEDDADYYCATWHa----sSYIFGGGTQLTV 131 African clawed frog
AAH73596   93 ISGAQAEDEADYYCQVWDs----gAYIFGGGTQLTV 124 African clawed frog

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