1HXM,1YPZ


Conserved Protein Domain Family
IgV_TCR_gamma

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cd04982: IgV_TCR_gamma 
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain
The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigens as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain the standard Ig superfamily V-set AGFCC'C"/DEB domain topology.
Statistics
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PSSM-Id: 409371
View PSSM: cd04982
Aligned: 13 rows
Threshold Bit Score: 150.592
Threshold Setting Gi: 1929952
Created: 17-Sep-2007
Updated: 17-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Structure:1HXM; human gamma/delta T-cell receptor (TCR) gamma chain IgV domain forms interface with delta chain IgV domain, contacts based on 3.5 A distance.
    View structure with Cn3D
  • Structure:1YPZ; mouse gamma/delta T-cell receptor (TCR) gamma chain IgV domain forms interface with delta chain IgV domain, contacts based on 3.5 A distance.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                      # # #     #                                    
1HXM_B      4 LEQPQISSTKTLSKTARLECVVSgi-tiSATSVYWYRERPGEVIQFLVSISyd-gTVRKesgipsgkFEVDRIpetsTST 81  human
1YPZ_F      4 LEQPEISISRPRDETAQISCKVFie-sfRSVTIHWYRQKPNQGLEFLLYVLat-pTHIFldkeykkmEASKNPsa-sTSI 80  house mouse
P01740     20 LEQTELSVTRETDENVQISCIVYlp-yfSNTAIHWYRQKTNQQFEYLIYVAtn-yNQRPlggk-hkkIEASKDfkssTST 96  house mouse
P03979     22 LEGRTKSVTRQTGSSAEITCDLTv---tNTFYIHWYLHQEGKAPQRLLYYDvstaRDVLesglspgkYYTHTPrr-wSWI 97  human
S36293     22 VEQAQISPSTEVKKSITIHCKIEst-dfESEAVYWYRQKRHQALEHLVYVIstttAARHqvdg-knkIEARKDarmfTST 99  sheep
AAA87009   55 LQQRQPSATRERSKTVTIQCHVEgiadfHNAYIHWYRQMPAGAPERLLYVTav-aQVSYdsdsyknkYTSSKMgn-kICT 132 chicken
AAB51490    2 LTQSQLSITKAPTKPVHFYCEVKni-diNEAIIHWYRQRPGEGLQWLLYFKsh-sDMQKdaa--aerFVAGKIpekkSCS 77  clearnose skate
AAB62728    1 LPLQPMFLVSAESKSIRITCDLGg---aSTSIIHWYRQPAGQRPVRILYYEs--gVNKRdsgf-gdrFEARLVvg-sQYS 73  clearnose skate
AAR18082   21 LQQSPVSVTKPESKTVLITCHVSvp-dfDKAFIHWYRTRPGAAPERVAYMAst-lFLANred--egkFSIEKDvgksLCT 96  mallard
EAL23984   19 VEQFQLSISTEVKKSIDIPCKISst-rfETDVIHWYRQKPNQALEHLIYIVstksAARRsmgktsnkVEARKNsqtlTSI 97  human
AAW24473   22 LVQTEVSVTGTREKSIIMSCKVFsk-dfSKDYIHWYRQKPDQGLEQLLFVLda-pALNDlggk-knkLEARKDkpssTST 98  cattle
AAY82106   22 LNQPVVSITRQYGMSATILCTFSd---nKNSFIHWYRQQPGKAPQRILYYNirasQTTMdsgftswkFQPDKIdd-rNCT 97  platypus
ABD93353   22 LEQKDLSMTKEEGKSVYISCKVTg---lATTYVHWYQQKDGEALTRILYVSsgskPVHDtthpvakdFDVRLQa--dKFD 96  channel catfish
Feature 1                   #   #          #   #       
1HXM_B     82 LTIHNVEKQDIATYYCALWEaqqelgkkIKVFGPGTKLIIT 122 human
1YPZ_F     81 LTIYSLEEEDEAIYYCSYGEgss---gfHKVFAEGTKLIVI 118 house mouse
P01740     97 LEINYLKKEDEATYYCAVWMrws--sgfHKVFAEGTKLIVI 135 house mouse
P03979     98 LRLQNLIENDSGVYYCATWDrxk--nyyKKLFGSGTTLVVT 136 human
S36293    100 LTVNFVEKEDVGIYYCAGWRk------gIKVFGEGTKLVVI 134 sheep
AAA87009  133 LSVQDIGDDDKGTYYCAYWEsrs--gyyYKVFGSGTKLIVS 171 chicken
AAB51490   78 LLLTNIRADDAGTYYCAYWKvats-gtwIKIFGSGTRLIVT 117 clearnose skate
AAB62728   74 LTVGDLKREDSATYFCAYWEsg----twIKIFGSGTRLIVT 110 clearnose skate
AAR18082   97 LTVTKVTLRDAGTYYCARWDa------dVKIFGTGTKLIVS 131 mallard
EAL23984   98 LTIKSVEKEDMAVYYCAAWDy-------TKLFGSGTTLVVT 131 human
AAW24473   99 LKISFLEKEDEATYYCAGWLlgs--stwIKVFGEGTKLVVI 137 cattle
AAY82106   98 LLIKDLDRNDTGIYYCAIWDcrn--gvyTAVFGSGTRLIIA 136 platypus
ABD93353   97 LKIANLKKSHSAVYYCASWEsdrt-gysYKVFGSGTRLFVT 136 channel catfish

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