2ADG,1IQD,1QLR,1RHH,1XIW,1XIW,1YJD,2C1O,3D85,3DGG,4I2X,5CMA,5DFV,6W41


Conserved Protein Domain Family
IgV_L_kappa

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cd04980: IgV_L_kappa 
Immunoglobulin (Ig) light chain, kappa type, variable (V) domain
The members here are composed of the immunoglobulin (Ig) light chain, kappa type, variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains.
Statistics
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PSSM-Id: 409369
View PSSM: cd04980
Aligned: 18 rows
Threshold Bit Score: 162.56
Threshold Setting Gi: 20269251
Created: 23-Apr-2007
Updated: 17-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Structure:2ADG; Mus musculus monoclonal anti-Cd4 antibody Q425, IgV light and heavy chain heterodimer interface, contacts based on 3.5 A distance.
    View structure with Cn3D
  • Structure:2ADG; Mus musculus monoclonal anti-Cd4 antibody Q425, Fab light and heavy chain interface (including constant domains of Fab), contacts based on 3.5 A distance.
    View structure with Cn3D
  • Comment:Dimerization of Ig domains from different chains is common, but not found in all members.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                            # # #    #  #   #                        
2ADG_A      2 TTVTQSPASLSVAIGEKVTIRCITSTdi-------dDDMNWYQQKPGEPPKFFISEgNTLRPGVPSRFSSSGYGTDFVFT 74  house mouse
1QLR_A      2 IVLTQSPATLSLSPGERATLSCGASQsv------ssNYLAWYQQKPGQAPRLLIYDaSSRATGIPDRFSGSGSGTDFTLT 75  human
2C1O_A     39 LVMTQSPLTLSVTIGQPASISCKSSQslly--sngkTYLNWLLQRPGQSPKRLIYLvSKLDSGDPDRFTGSGSGTDFTLK 116 house mouse
3D85_A      2 IVMTQSPATLSVTPGDRVSLSCRASQsi-------sDYLHWYRQKSHESPRLLIKYaSQSISGIPSRFSGSGSGSDFTLS 74  human
3DGG_A      2 IVLTQSPASLAVSLGQRATISCRASKsvst---sgySYMHWYQQKPGQPPKLLIYLaSNLESGVPARFSGSGSGTDFTLN 78  human
5CMA_A      2 IVMTQSPATLSVTPGDRVSLSCRASQsi-------sDYLHWYQQKSHESPRLLIKYaSQSISGIPSRFSGSGSGSDFTLS 74  house mouse
5DFV_D      2 IVLTQSPASLSVSLGQRATISCRASKsvst---siySYMHWYQQKPGQPPKLLIKYaSYLESGVPARFSGSGSGTDFTLN 78  house mouse
6W41_L      2 IQLTQSPDSLAVSLGERATINCKSSQsvlys-sinkNYLAWYQQKPGQPPKLLIYWaSTRESGVPDRFSGSGSGTDFTLT 80  human
P01681      2 VQMTQSPSYLAASPGESVSISCKASNks------isNNLAWYZZKPGKANKLLISSgSTLQSGTPSRFSGSGSDTDFTLT 75  Norway rat
AAG31729   22 VTVTQSPAGKMVQVGESVTITCKTNMivsnncpgsyTCMSWYQQKPGEAPKLLIYA-NQKQSNTPSRFSGSGSRTDFTLS 100 zebrafish
Feature 1                 #                       
2ADG_A     75 IENMLSEDVADYYCLQSDTl----PLTFGSGTKLEI 106 house mouse
1QLR_A     76 ISRLEPEDFAVYYCQQYGSs----PLTFGGGTKVEI 107 human
2C1O_A    117 ISRVEAEDLGIYYCVQGSHf----PPTFGAGTKLEL 148 house mouse
3D85_A     75 INSVEPEDVGVYYCQNGHSf----PFTFGSGTKLEI 106 human
3DGG_A     79 IHPVEEEDAATYYCQHSRE-----LLTFGAGTKLEL 109 human
5CMA_A     75 INSVEPEDVGVYYCQNGHSf----PLTFGAGTKLEL 106 house mouse
5DFV_D     79 IHPVEEEDAATYYCEHSREf----PFTFGTGTKLEI 110 house mouse
6W41_L     81 ISSLQAEDVAVYYCQQYYSt----PYTFGQGTKVEI 112 human
P01681     76 IRSLEFQDFAVYYCZZYNEp----YYTFGAGTMLEL 107 Norway rat
AAG31729  101 ISGVQTEDAGDYYCLSLHWinskaVYTFGGGTKLLI 136 zebrafish

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